241 research outputs found

    Arts, struggle and transformation from female militants to Kurdish women

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    69 pagesI wanted to evaluate the women‟s rights movements through the lives and struggles of two important Kurdish women of social worth who lived in the 21st century to answer the question of whether women could really exist in new battlegrounds apart from being objects of consideration and militarism. My first example is how Sakine Cansız has managed to create a public space within the Kurdish women‟s rights movement throughout her life and whether she extended beyond masculine discourse after her death. Sakine Cansız has become an important public figure because she constructed the female memory of the Kurdish public movement. During her life, although she tried not to remain constrained within the masculine political discourse, she could not necessarily extend beyond it either. It was an important ethnographic example to examine and analyze her life as well as the symbolic values of her funeral. It was possible to read how the areas of female struggle and how a new Kurdish female figurine surfaced through Sakine Cansız‟s funeral. She was the messenger of the formation of a new Kurdish female model: a new type of Kurdish woman who did not exist only within the war apparatus or the political discourse and who did not behave sexless. This type of Kurdish woman represents all the women who are capable of using different tools and apparatus to fight hegemony to contribute a serious universal awareness as well as symbolic values to the public space. Just like Zehra Doğan who could carry out a feminist struggle with her male comrades, could underline her female identity and struggled as a Kurdish woman.Kadın hareketlerinin 21. Yüzyılda dönüşümünü yaşan ve ölen iki önemli toplumsal Kürt kadın figürü üzerinden ele alıp, halk hareketlerinde kadınların bedel ve savaşçılık nesnesi olmaları dışında yeni mücadele alanlarında var olabilirler mi sorusunu sormak istedim. İlk örneğim Sakine Cansız‟ın yaşamı boyunca Kürt kadın hareketi içerisinde nasıl bir kamusal alan oluşturduğu ve ölümünden sonra eril söylemlerin dışına çıkıp çıkamadığı sorunsalı. Sakine Cansız, Kürt halk hareketinin kadın hafızasını oluşturduğu için önemli bir kamusal figür haline gelmişti. Yaşamı içerisinde, eril politik söylem içerisinde, kısıtlı kalmayaya çalışsa da, bunun dışına tam olarak çıkmış da değildir. Yaşamı ve cenazesinin sembolik değerlerinin incelenmesi önemli bir etnografik örnekti. Kadınların mücadele alanlarının nasıl değiştiği, yeni bir kürt kadın figürünün ortaya çıktığını Sakine Cansız cenazesi üzerinden okumak mümkündü. Yeni bir Kürt kadın modelinin oluştuğunun habercisiydi. Kendini salt savaş araçları ve ya politik söylem içerisinde var etmeyen, cinsiyetsiz gibi davranmayan yeni bir Kürt kadını. Bu Kürt kadını, hegemonya ile savaşmak için başka araçlar kullanabilen büyük bir evrensel farkındalık ve kamusal alanda bir sembol değer yaratabilen kadınlar. Kendi erkek yoldaşları ile feminist mücadele yürütebilen, kadın kimliğinin altını çizen, Kürt kadını olarak mücadele veren Zehra Doğan gibi

    Maternal hypoglycaemia on the 50 g oral glucose challenge test — evaluation of obstetric and neonatal outcomes

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      Objectives: To discuss obstetric and neonatal outcomes of maternal hypoglycaemia observed after the 50 g oral glucose challenge test. Material and methods: A retrospective evaluation was made of the results of patients at 24–28 weeks gestation of a live singleton pregnancy who underwent a 50 g OGCT at the Health Sciences University Gazi Yaşargil Training and Research Hos­pital, between September 2016 and August 2017. In the 50 g OGCT, 1-hour blood glucose results were divided into Low OGCT (< 90 mg/dL) and Normal OGCT (90–139 mg/dL). The groups were compared in respect of obstetrics and neonatal outcomes. Results: Of 2623 pregnant patients applied with the 50 g OGCT, blood glucose was < 140 mg/dL in 77.16% (n = 2024), with 11.9% (n = 312) in the Low OGCT group, and the remaining 65.26% (n = 1712) in the Normal OGCT group. Based on the comparison of the groups, the SGA rate was 7% in the Low OGCT group and 4% in the Normal OGCT group; the 5th minute APGAR score was < 7 in 2% of the Low OGCT group and in 1% of the Normal OGCT group, while caesarean section rates were 25% and 32% respectively (p < 0.05). Conclusions: The results of the study showed a significant association between maternal hypoglycaemia and increased SGA rate, decreased 5-minute APGAR scores and reduced caesarean section rates, and this relationship should be confirmed with further comprehensive studies

    The factors effecting the grade of academicians’ satisfaction level: The reality of major field of study for classroom training

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    The aim of the research is to find out the satisfaction levels of the academicians in the main science branch of class education; management and organizing, education, research, infrastructure and stakeholder relations subscales according to some demographic variables. Mixed method, explicative sequential pattern was used in the research. A sample of 21 academics working at the university, identified as easily accessible, constitutes the working group, with five academics identified according to the criteria sample of the purposeful sample. Quantitative data were collected through the "Mehmet Akif Ersoy University Academic Staff Satisfaction Survey" and qualitative data were collected through semi-structured interview form. Quantitative data were analyzed by SPSS program and qualitative data by descriptive analysis method. When the findings are examined; the level of satisfaction of academicians did not make a meaningful difference according to their titles, and they showed according to their genders. In addition, the most positive opinion of academicians was sub-dimension, while the most negative was infrastructure. The quantitative findings obtained were examined in depth and the direct opinions of academicians were included. The research was discussed within the framework of related literature and similar study findings and various suggestions were made.The aim of the research is to find out the satisfaction levels of the academicians in the main science branch of class education; management and organizing, education, research, infrastructure and stakeholder relations subscales according to some demographic variables. Mixed method, explicative sequential pattern was used in the research. A sample of 21 academics working at the university, identified as easily accessible, constitutes the working group, with five academics identified according to the criteria sample of the purposeful sample. Quantitative data were collected through the "Mehmet Akif Ersoy University Academic Staff Satisfaction Survey" and qualitative data were collected through semi-structured interview form. Quantitative data were analyzed by SPSS program and qualitative data by descriptive analysis method. When the findings are examined; the level of satisfaction of academicians did not make a meaningful difference according to their titles, and they showed according to their genders. In addition, the most positive opinion of academicians was sub-dimension, while the most negative was infrastructure. The quantitative findings obtained were examined in depth and the direct opinions of academicians were included. The research was discussed within the framework of related literature and similar study findings and various suggestions were made

    Three-Dimensional Structure of the Complexin/SNARE Complex

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    During neurotransmitter release, the neuronal SNARE proteins synaptobrevin/VAMP, syntaxin, and SNAP-25 form a four-helix bundle, the SNARE complex, that pulls the synaptic vesicle and plasma membranes together possibly causing membrane fusion. Complexin binds tightly to the SNARE complex and is essential for efficient Ca2+-evoked neurotransmitter release. A combined X-ray and TROSY-based NMR study now reveals the atomic structure of the complexin/SNARE complex. Complexin binds in an antiparallel α-helical conformation to the groove between the synaptobrevin and syntaxin helices. This interaction stabilizes the interface between these two helices, which bears the repulsive forces between the apposed membranes. These results suggest that complexin stabilizes the fully assembled SNARE complex as a key step that enables the exquisitely high speed of Ca2+-evoked neurotransmitter release

    Evaluation of Distance Education Management Processes in Higher Education Institutions in Istanbul

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    Uzaktan eğitim süreciyle ilgili dünyada ve ülkemizde uzun yıllardır bilimsel çalışmalar yapıldığı, süreçle ilgili çalışmalar yürütüldüğü görülmektedir. Ancak uzaktan eğitimin öneminin özellikle COVID-19 pandemisi döneminde daha iyi anlışıldığı ifade edilebilir. Araştırmanın amacı; üniversitelerde Uzaktan Eğitim Uygulama ve Araştırma Merkezi yöneticilerinin uzaktan eğitim sürecine ilişkin görüşlerini alarak uzaktan eğitim sürecini belirlemek ve değerlendirmek, mevcut durumu ile olması gerekeni belirleyerek sürecin nasıl daha etkili olabileceğine ilişkin saptamalar yapmaktır. Araştırma nitel araştırma yöntemiyle yürütülmüştür. Çalışma grubu belirlenirken amaçlı örnekleme yöntemlerinden kolay ulaşılabilir örneklem kullanılmış olup araştırma için gönüllü olan 2 devlet üniversitesi ile 6 vakıf üniversitesi bünyesinde bulunan UZEM’lerde görev yapan 8 yönetici çalışma grubunu oluşturmuştur. Veriler yarı yapılandırılmış görüşme formu aracılığı ile toplanmış ve içerik analizi ile çözümlenmiştir. COVID-19 pandemisiyle önem kazanan ve gelecekte de bu önemin artarak süreceği varsayımıyla, uzaktan eğitim yönetimine ilişkin bilgilerin, açıklamaların betimlenmesinin, olması gereken durumlara açıklık getirilmesinin literatüre katkı sağlayacağı düşünülmektedir. Araştırmanın önemli olarak belirtilebilecek bulgularından biri, uzaktan eğitim sitemleri tercih edilirken eğitim amaçlı ya da eğitime uyarlanabilen platform olmalarına dikkat edildiği, sonrasında ise hazırbulunuşluk, güvenlik, maliyet, etkileşim ve gelişime elverişlilik hususlarının geldiği ve bu hususların öncelik sırasının kurumların ihtiyaçları ve koşulları doğrultusunda değiştiğidir.It is observed that scientific studies have been carried out for many years in the World and in our country regarding the distance education process. However, it can be stated that the importance of distance education is better understood, especially amid the COVID-19 pandemic. The purpose of the research is to designate and evaluate the distance education process by taking the opinions of the Distance Education Application and Research Center (UZEM) managers in universities on the distance education process and to determine the status quo and what should be done accordingly in order to make the process more effective. The research was carried out with the qualitative research method. While determining the study group, an easily accessible sample, which is one of the purposive sampling methods, was used and eight administrators working in Distance Education Centers (UZEM) within two state universities and six foundation universities volunteered for the research. The data were collected through a semistructured interview form and analyzed by content analysis. Gaining importance with the COVID-19 pandemic and with the assumption that this importance will continue to increase in the future, it is thought that describing the information and explanations about distance education management and clarifying the necessary situations will contribute to the existing literature. One of the most important findings of the research is that, while adopting distance education systems, attention is paid to the fact that the platforms are those which can be adapted to required education or training. Readiness, security, cost, interaction and convenience for development come next, and the order of priority of these issues changes in line with the needs and conditions of the institutions

    A GAIN in understanding autoproteolytic G protein‐coupled receptors and polycystic kidney disease proteins

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    Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/102153/1/embj201251.pd

    Comparison of Synthetic Dura and Autologous Dura in Terms of Complication Development in Children Aged 0-1 Years Who Underwent Surgery for Meningocele and Myelomeningocele

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    Abstract: Aim: The aim of this study is to compare the usage of synthetic and autologous dura mater in terms of complication risk in 0-1-year-old children who were operated for meningocele and myelomeningocele. Material and Methods: This cross-sectional observational study was conducted with 44 children aged 0-1 years who were operated for meningocele and myelomeningocele in a university hospital neurosurgery clinic between November 2010 and December 2016. Patient data were extracted retrospectively from hospital records. The demographics and gestational and clinical features of the mothers and babies, and the need for secondary surgery and the presence of postoperative infection, necrosis, wound dehiscence, and/or neurological deficit were compared between the cases who synthetic dura mater was used in their surgery and those autologous dura was used in their surgery. Results: In total, 86.4% of the 44 infants were preterm, and the predominant neurological problem was plegia in the vast majority. While the defect was located in the lumbar region in more than half of them, myelomeningocele was detected in 77.3% of all cases. The median defect size detected in the patients was 20.0 cm2, primary closure was performed in 30 patients, Limberg flap procedure in 14 patients, however, autologous dura mater and synthetic dura mater were used equally in the patients. The defect size was larger in patients using synthetic dura, furthermore hydrocephalus was found more frequently in these patients. While primary closure was applied in all patients using autologous dura and in one third of the patients using synthetic dura, Limberg flap procedure was applied in two thirds of synthetic dura group. The need for secondary surgery developed more frequently in synthetic dura group, and all postoperative complications were observed more frequently in these patients. In addition, the need for secondary surgery and postoperative necrosis, wound dehiscence, and neurologic deficit are more frequent in patients who underwent Limber flap compared to primary closure. However, the need for secondary surgery and the risk of postoperative complications were similar between primary closure and Limberg flap procedures in synthetic dura group. Conclusion: Although the synthetic dura mater was used in more severe patients, it had a higher need for secondary surgery and a higher risk of complications compared to autologous dura. In patients using synthetic dura, on the other hand, primary closure and Limberg flap had similar efficacy and safety

    Mechanism for Adhesion G Protein-Coupled Receptor GPR56-Mediated RhoA Activation Induced By Collagen III Stimulation

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    GPR56 is a member of the adhesion G protein-coupled receptor (GPCR) family. Despite the importance of GPR56 in brain development, where mutations cause a devastating human brain malformation called bilateral frontoparietal polymicrogyria (BFPP), the signaling mechanism(s) remain largely unknown. Like many other adhesion GPCRs, GPR56 is cleaved via a GPCR autoproteolysis-inducing (GAIN) domain into N- and C-terminal fragments (GPR56N and GPR56C); however, the biological significance of this cleavage is elusive. Taking advantage of the recent identification of a GPR56 ligand and the presence of BFPP-associated mutations, we investigated the molecular mechanism of GPR56 signaling. We demonstrate that ligand binding releases GPR56N from the membrane-bound GPR56C and triggers the association of GPR56C with lipid rafts and RhoA activation. Furthermore, one of the BFPP-associated mutations, L640R, does not affect collagen III-induced lipid raft association of GPR56. Instead, it specifically abolishes collagen III-mediated RhoA activation. Together, these findings reveal a novel signaling mechanism that may apply to other members of the adhesion GPCR family
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