33 research outputs found
Noninferiority of Preservative-free Versus BAK-preserved Latanoprost-timolol Fixed Combination Eye Drops in Patients With Open-angle Glaucoma or Ocular Hypertension
Précis: Noninferiority of efficacy was demonstrated for a preservative-free latanoprost-timolol fixed combination compared with a BAK-containing formulation at 84 days after treatment in patients with open-angle glaucoma or ocular hypertension.
Purpose: The purpose of this study was to compare the effect on intraocular pressure and safety of preservative-free latanoprost-timolol fixed combination (T2347) to benzalkonium chloride-preserved latanoprost-timolol fixed combination in patients with open-angle glaucoma or ocular hypertension.
Methods: Phase III, randomized, parallel-group, investigator-masked study in 10 countries. A total of 242 patients aged 18 years or older with open-angle glaucoma or ocular hypertension in both eyes controlled with a preserved latanoprost-timolol fixed combination (15.7±2.4 mm Hg overall before inclusion) were randomized at day 0 with no washout period to receive the preservative-free alternative T2347 (N=127) or remain on the preserved comparator (N=115) for 84 days. Intraocular pressure changes from day 0 were measured at 9:00 am (±1 hour) on day 42 and day 84, and noninferiority of T2347 to the preserved comparator was analyzed statistically at day 84. Safety parameters were also reported.
Results: The mean change in intraocular pressure from baseline to day 84 was -0.49±1.80 mm Hg for preservative-free T2347 and -0.49±2.25 mm Hg for the preserved comparator. These results met the noninferiority limits. Similar results were observed at day 42. There was no difference between groups in the incidence of adverse events or ocular signs. The total ocular symptoms score was better for T2347 than BPLT upon instillation at day 84 (45.9%/44.3%/9.8% of patients with improvement/no change/worsening vs. 33.6%/47.3%/19.1%; P=0.021), reflecting improvements in individual symptoms such as irritation/burning/stinging (P<0.001), and itching (P<0.01) on day 84.
Conclusions: Preservative-free latanoprost-timolol fixed combination T2347 showed noninferior efficacy compared with the preserved comparator and was well tolerated
Procédé hybride de coagulation/ultrafiltration pour la potabilisation des eaux de surface
TOULOUSE3-BU Sciences (315552104) / SudocSudocFranceF
13. Les technologies membranaires
Les membranes permsélectives* utilisées en traitement des eaux continentales peuvent être définies comme des filtres possédant des pores de diamètres très petits : de l’ordre de 0,1 μm pour la microfiltration*, de 0,01 μm pour l’ultrafiltration* et de 0,001 μm pour la nanofiltration*. Les pores d’un filtre à sable, qui permet de tamiser les particules (cf. V.12), sont, quant à eux, de l’ordre de 10 μm. Ces membranes permettent donc l’arrêt de particules dont le diamètre est de 100 à 1 000 foi..
Procédé de photogreffage en continu de membranes fibres creuses
TOULOUSE3-BU Sciences (315552104) / SudocSudocFranceF
Electrochemical measurement of velocity grandient at the wall of a helical tube
International audienc
Removal of volatile organic components (VOCs) from water by pervaporation: separation improvement by Dean vortices
International audienc
Mass transfer improvement in helically wound hollow fibre ultrafiltration modulesYeast suspensions
International audienc
Mass transfer improvement by secondary flows: Dean vortices in coiled tubular membranes
International audienc
Ultrafiltration as a nonpolluting alternative to traditional clarification in water treatment
International audienc