1 research outputs found
The burden, pattern and factors that contribute to periportal fibrosis in HIV-infected patients in an S. mansoni endemic rural Uganda.
Introduction: Both Human Immunodeficiency Virus (HIV) and S.mansoni
infections are common in Uganda and can cause liver disease. No study
has determined co-infection significance in Uganda. We carried out a
study on the burden, pattern and factors that contribute to peri-portal
fibrosis (PPF) in HIV infected patients attending a Primary healthcare
setting at Pakwach. Methodology: We conducted a cross-sectional study
in the HIV clinic at Pakwach health centre IV. Data on demographics,
contact with the Nile, CD4+ cell count, ART and alcohol use were
collected. Urinary Circulating Cathodic Antigen (CCA), was done for S.
Mansoni detection. Liver scan was done for presence and pattern of PPF.
HBsAg testing was performed on all participants. Data was analyzed
using Stata Version 10. Results: We enrolled 299 patients, median age
39 years (IQR 16), most were female, 210 (73%). Overall, 206 (68.9%)
had PPF, majority 191 (92.7%) had pattern c, either alone (63
participants) or in combination with pattern d (128 participants). Age
of 30-50 years was significantly associated with PPF (OR 2.28
p-value-0.003) Conclusion: We found high prevalence of S. mansoni and
PPF in the HIV infected population and age was a significant factor for
PPF. We recommend all HIV infected patients be examined routinely for
S. mansoni infection for early anti-schistosomal treatment