Development of a continuous measurement system for atmospheric N2O and CO concentrations and its application to in-situ observation at Syowa Station, Antarctica

The Tenth Symposium on Polar Science/Ordinary sessions: [OM] Polar Meteorology and Glaciology, Wed. 4 Dec. / Entrance Hall (1st floor) , National Institute of Polar Researc

Development of 3-Cylinder Rotary Compressor for Large Capacity

The authors have developed a large capacity rotary compressor with compact size and low vibration. Recently, we have strong requirements for larger capacity without changing the compressor shell diameter. Considering for larger capacity in conventional 2-cylinder rotary compressor inverter type, there are issues such as high vibration, big sound. As the solution for these problems, we have developed 3-cylinder rotary compressor inverter type which have different compression process of 120 ° phase per revolution for each cylinder. The developed compressor achieves a capacity target, proves one-quarter vibration level comparing with 2-cylinder rotary compressor and ensure the improvement of reliability result. We have been manufacturing the world largest capacity of new rotary compressor and have been launching into the market since September 2020. This new model has successfully attained more large capacity with same shell diameter as our previous large capacity of 2-cylinder rotary compressor inverter type. This new model adopt some new technologies such as the 3-cylinder design for balancing rotation torque, the multi discharge valve structure, the integrated bearing with partition plate and the new wide-range motor. By these technologies, the outdoor units of multiple air conditioner for buildings (Variable Refrigerant Flow-VRF) can achieve a large capacity 20 HP (56kW) with applying one compressor unit only

縞状鉄鉱層の地質学・地球化学的研究 : 海洋遷移金属元素組成の経年変化の復元

学位の種別: 課程博士審査委員会委員 : （主査）東京大学准教授 小宮 剛, 東京大学准教授 小河 正基, 東京大学教授 鈴木 建, 東京大学教授 松尾 基之, 東京大学教授 磯崎 行雄University of Tokyo(東京大学

Very-Low-Dose Pegylated Interferon a2a Plus Ribavirin Therapy for Advanced Liver Cirrhosis Type C: A Possible Therapeutic Alternative without Splenic Intervention

Despite the recent progress in interferon (IFN) therapies for chronic hepatitis C, liver cirrhosis remains refractory. One of the major obstacles to successful IFN therapy is low platelet count. Currently, splenic interventions, such as partial splenic embolization (PSE) or surgical splenectomy, have been applied effectively and make standard IFN therapy possible. However, there may be a group of patients with low platelet counts who can be treated without splenic intervention. We here report two patients with advanced type C liver cirrhosis who were successfully treated using very-low-dose pegylated interferon a2a plus ribavirin. One patient had a very low platelet count (2.5 × 104/μl) due to splenomegaly before treatment. However, pretreatment serum HCV titers were low in both patients and early viral responses were obtained in both. Because PSE or splenectomy may still have some safety concerns, this attenuated IFN treatment protocol can be an alternative therapeutic option for patients with advanced type C liver disease, but good virological factors for sustained virological response

Isolation and identification of the antimicrobial substance included in tempeh using Rhizopus stolonifer NBRC 30816 for fermentation

In this study, we focus on the antimicrobial properties of tempeh, a soybean fermented food, against oral bacteria. Tempeh showed antimicrobial activity against dental caries pathogenic bacterium Streptococcus mutans at a final concentration of 1 mg/mL. An antimicrobial substance contained in tempeh was present in the 100 kDa or greater fraction generated by ultrafiltration, but it was found not to be proteinaceous by native-PAGE, SDS-PAGE and protein degradation tests. Next, when the fraction was purified with an ODS column, the 80% and 100% methanol eluates showed antimicrobial activity against S. mutans. The 100% methanol eluate was further subjected to a 2nd column purification, and isolation of the target was confirmed by HPLC. When the isolated material was analyzed by ESI-MS, the m/z was 279.234. Further analysis by Raman spectroscopy revealed a peak similar to linoleic acid. This substance also possessed antimicrobial properties equivalent to linoleic acid

Home visits provide a better understanding of the psychopathology of a case of eating disorder

Eating disorders (ED) are characterized by abnormal eating behaviors that negatively affect the patient’s medical or psychiatric health, with symptoms usually developing during adolescence. Treatment for ED varies across patients and the disease time-course, reflecting differences in psychopathology and medical comorbidities. Here, we provide a brief review of the standard management strategy for ED and emphasize the importance of individualized treatment. To illustrate this, we present a case of ED in which a halt in development was observed during a home visit, which is an unusual component in the treatment of ED. Furthermore, as a result of our collective experience in treating ED, we recognize that discussion among multidisciplinary healthcare professionals is important to improve outcomes

Isorhamnetin Promotes 53BP1 Recruitment through the Enhancement of ATM Phosphorylation and Protects Mice from Radiation Gastrointestinal Syndrome

Flavonoids are a subclass of polyphenols which are attractive, due to possessing various physiological activities, including a radioprotective effect. Tumor suppressor p53 is a primary regulator in the radiation response and is involved in the pathogenesis of radiation injuries. In this study, we revealed that isorhamnetin inhibited radiation cell death, and investigated its action mechanism focusing on DNA damage response. Although isorhamnetin moderated p53 activity, it promoted phosphorylation of ataxia telangiectasia mutated (ATM) and enhanced 53BP1 recruitment in irradiated cells. The radioprotective effect of isorhamnetin was not observed in the presence of ATM inhibitor, indicating that its protective effect was dependent on ATM. Furthermore, isorhamnetin-treated mice survived gastrointestinal death caused by a lethal dose of abdominal irradiation. These findings suggested that isorhamnetin enhances the ATM-dependent DNA repair process, which is presumably associated with the suppressive effect against GI syndrome