Ni(II) Complex of a Novel Schiff Base Derived from Benzaldehyde and Sulphathiazole: Synthesis, Characterization and Antibacterial Studies

Communication in Physical Sciences 2020, 5(2): 145-155 Authors: Ifeanyi. E. Otuokere, J.C. Anyanwu and K.K. IgweReceived 09April 2020/Accepted 01May 2020 New Schiff base and its Ni(II) complex, were synthesized using benzaldehyde and sulphathiazole. They were characterized usingelemental analyser, UV-visible spectrophotometer, FTIR, 1H-NMR and 13C-NMR spectroscopy. IR spectral data suggested that the ligand coordinated to nickel ions through two azomethine nitrogen, and one amine nitrogen. Electronic spectral measurement indicated the occurrence of ligand to metal charge transfer. Based on the continuous variation method, metal: ligand ratio of 1:1 was proposed. Elemental analysis and spectroscopic studies suggested that the Schiff base behaved as a tridentate ligand towards nickel ion. Antibacterial sensitivity of the ligand and its Ni (II) complex were assayed in vitro against Staphylococcusaureus, Echerichia coli, Pseudomonas aeruginosa and Salmonella typhi. It was observed that the Ni(II) complex was more potent than the Schiff base against the bacterial strains used. Therefore, the Schiff base and its Ni(II) complex may inhibit bacterial infections caused by E.coli, P.aeruginosa,S. typhi and S.aureus. The Ni(II) complex showed enhanced antibacterial activity when compared with the pure the Schiff base.&nbsp

Synthesis, Spectra and Antibacterial Studies of 4-{[(E)-phenylmethyl- idene]amino}-N-(1,3-thiazol-2-yl)benzenesulfonamide Schiff Base Ligand and its Ni(II) Complex

Communication in Physical Sciences 2021, 7(2):115-125 Authors: Ifeanyi. E. Otuokere, J.C Anyanwu and K.K Igwe Received 09 April 2021/Accepted 01 June 2021 A novel Schiff base and its Ni(II) complex have synthesized from benzaldehyde and sulphathiazole. The synthesized products were characterized using elemental analyser, ultra violet visible, Fourier transformed infra red, proton and carbon-13 spectrophotometers. Results obtained from infra red spectrum suggested that the ligand is coordinated to nickel ions through two azomethine nitrogen, and one amine nitrogen. Electronic spectral measurement indicated that there is a ligand to metal charge transfer and from the continuous variation method, metal: ligand ratio of 1:1 was proposed. Elemental analysis and spectroscopic studies suggested that the Schiff base behaved as a tridentate ligand towards nickel ion. In vitro antibacterial sensitivity tests of the ligand and its Ni  (II)  complex against Staphylococcus aureus, Echerichia coli, Pseudomonas aeruginosa and Salmonella typhi showed that they exhibited strong activities. However, the Ni(II) complex was observed to be more potent than the  Schiff base

Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries

© 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 licenseBackground: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Methods: This was a multicentre, international prospective cohort study of consecutive adult patients undergoing surgery for primary breast, colorectal, or gastric cancer requiring a skin incision done under general or neuraxial anaesthesia. The primary outcome was death or major complication within 30 days of surgery. Multilevel logistic regression determined relationships within three-level nested models of patients within hospitals and countries. Hospital-level infrastructure effects were explored with three-way mediation analyses. This study was registered with ClinicalTrials.gov, NCT03471494. Findings: Between April 1, 2018, and Jan 31, 2019, we enrolled 15 958 patients from 428 hospitals in 82 countries (high income 9106 patients, 31 countries; upper-middle income 2721 patients, 23 countries; or lower-middle income 4131 patients, 28 countries). Patients in LMICs presented with more advanced disease compared with patients in high-income countries. 30-day mortality was higher for gastric cancer in low-income or lower-middle-income countries (adjusted odds ratio 3·72, 95% CI 1·70–8·16) and for colorectal cancer in low-income or lower-middle-income countries (4·59, 2·39–8·80) and upper-middle-income countries (2·06, 1·11–3·83). No difference in 30-day mortality was seen in breast cancer. The proportion of patients who died after a major complication was greatest in low-income or lower-middle-income countries (6·15, 3·26–11·59) and upper-middle-income countries (3·89, 2·08–7·29). Postoperative death after complications was partly explained by patient factors (60%) and partly by hospital or country (40%). The absence of consistently available postoperative care facilities was associated with seven to 10 more deaths per 100 major complications in LMICs. Cancer stage alone explained little of the early variation in mortality or postoperative complications. Interpretation: Higher levels of mortality after cancer surgery in LMICs was not fully explained by later presentation of disease. The capacity to rescue patients from surgical complications is a tangible opportunity for meaningful intervention. Early death after cancer surgery might be reduced by policies focusing on strengthening perioperative care systems to detect and intervene in common complications. Funding: National Institute for Health Research Global Health Research Unit

Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licenseBackground: Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide. Methods: A multimethods analysis was performed as part of the GlobalSurg 3 study—a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital. Findings: Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3·85 [95% CI 2·58–5·75]; p<0·0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63·0% vs 82·7%; OR 0·35 [0·23–0·53]; p<0·0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer. Interpretation: Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised. Funding: National Institute for Health and Care Research