Analysing the Socio-Economic Conditions of Waste Pickers in Uttar Pradesh

Waste pickers pick up reusable and recyclable waste from roadsides, dustbins, and landfills and sell it to local scrap dealers to earn money to fulfil their daily needs. Waste pickers do this in very unhygienic and hazardous conditions. This study examines the socio-economic status of waste pickers working in Ghaziabad using the Kuppuswamy SES (2020) scale. For this, 200 waste pickers, including male and female respondents, participated in this study. IBM SPSS software was used to code and analyse the data.  Correlation matrix and regression were used for analysis. The research found that although waste pickers are crucial to society, their socio-economic situation is among the lowest. 51% of waste pickers are from the lower middle class, and 42% are from the upper lower class. These waste pickers of our study are underprivileged, illiterate, and live in poor conditions. For a sustainable and decent living, they need the government to satisfy some of their needs, including free medical services, access to clean, fresh water, social safety, and training for alternative employment

Age-​related changes in the brain antioxidant status: modulation by dietary supplementation of Decalepis hamiltonii and physical exercise

The synergistic effects of phys. exercise and diet have profound benefits on brain function. The present study was aimed to det. the effects of exercise and Decalepis hamiltonii (Dh) on age-​related responses on the antioxidant status in discrete regions of rat brain. Male Wistar albino rats of 4 and 18 mo old were orally supplemented with Dh ext. and swim trained at 3 % intensity for 30 min​/day, 5 days​/wk, for a period of 30 days. Supplementation of 100 mg Dh aq. ext.​/kg body wt. and its combination with exercise significantly elevated the antioxidant enzyme activities irresp. of age. Age-​related and region-​specific changes were obsd. in superoxide levels, and protein carbonyl and malondialdehyde contents, and were found to be decreased in both trained and supplemented groups. Levels of total thiols, protein, and nonprotein thiols decreased with age and significantly increased in the SW-​T(+100 mg) groups. Our results demonstrated that the interactive effects of two treatments enhanced the antioxidant status and decreased the risk of protein and lipid oxidn. in the rat brai

Age-Related Changes in the Brain Antioxidant Status: Modulation by Dietary Supplementation of Decalepis Hamiltonii and Physical Exercise

The synergistic effects of physical exercise and diet have profound benefits on brain function. The present study was aimed to determine the effects of exercise and Decalepis hamiltonii (Dh) on age-related responses on the antioxidant status in discrete regions of rat brain. Male Wistar albino rats of 4 and 18 months old were orally supplemented with Dh extract and swim trained at 3 % intensity for 30 min/day, 5 days/week, for a period of 30 days. Supplementation of 100 mg Dh aqueous extract/kg body weight and its combination with exercise significantly elevated the antioxidant enzyme activities irrespective of age. Age-related and region-specific changes were observed in superoxide levels, and protein carbonyl and malondialdehyde contents, and were found to be decreased in both trained and supplemented groups. Levels of total thiols, protein, and nonprotein thiols decreased with age and significantly increased in the SW-T(+100 mg) groups. Our results demonstrated that the interactive effects of two treatments enhanced the antioxidant status and decreased the risk of protein and lipid oxidation in the rat brain

Dryland Agriculture: Dynamics, Challenges and Priorities

The developments in the dryland region reflect the pervasiveness of poverty, which is demonstrated by the growing constraints of water, land degradation, continuing concerns about malnutrition, migration due to frequent droughts, lack of infrastructure, poor dissemination of improved technologies, and effects of government policies and further economic liberalization on the competitiveness of dryland crops. This research bulletin reviews past trends, summarizes the major constraints to income growth, food security, poverty alleviation, and environmental sustainability, and identifies future strategies and priorities. The discussion uses the semi-arid tropics as a focal point where poverty, food insecurity, child malnutrition and gender inequalities are widespread. A synthesis of evidence and lessons learned from ICRISAT Village Level Studies (VLS), conducted since 1975, is presented to provide empirical evidence on the vulnerability of the poor to various risks and shocks, as well as their capacity to access physical, financial and social resources and networks in the risky environments of the drylands. An analysis of available evidences provided a basis for identifying major policy issues that need to be addressed. Priority development interventions are identified to accelerate the pace of development of dryland agriculture: a) water as a catalyst for development; b) reorientation of public policies and better targeting of development interventions to dryland farmers, especially since they relate to key factors constraining agricultural productivity, and hence poverty reduction; c) diversification with a higher focus on crop-livestock development; d) innovative, cost effective and community based management of wastelands and common property resources; e) marketing, commercial orientation and competitiveness of dryland agriculture; and f)institutional innovations, building partnerships, linkages and capacity. The development of dryland agriculture requires synergy among technologies, marketing systems, input supplies, credit, policies and institutions. A broadbased sustainable growth and development in the drylands of Asia and sub-Saharan Africa is viewed as a key strategy for addressing rural poverty in the Asian and sub-Saharan region

Dryland Agriculture: Dynamics, Challenges and Priorities

The developments in the dryland region reflect the pervasiveness of poverty, which is demonstrated by the growing constraints of water, land degradation, continuing concerns about malnutrition, migration due to frequent droughts, lack of infrastructure, poor dissemination of improved technologies, and effects of government policies and further economic liberalization on the competitiveness of dryland crops. This research bulletin reviews past trends, summarizes the major constraints to income growth, food security, poverty alleviation, and environmental sustainability, and identifies future strategies and priorities. The discussion uses the semi-arid tropics as a focal point where poverty, food insecurity, child malnutrition and gender inequalities are widespread. A synthesis of evidence and lessons learned from ICRISAT Village Level Studies (VLS), conducted since 1975, is presented to provide empirical evidence on the vulnerability of the poor to various risks and shocks, as well as their capacity to access physical, financial and social resources and networks in the risky environments of the drylands. An analysis of available evidences provided a basis for identifying major policy issues that need to be addressed. Priority development interventions are identified to accelerate the pace of development of dryland agriculture: a) water as a catalyst for development; b) reorientation of public policies and better targeting of development interventions to dryland farmers, especially since they relate to key factors constraining agricultural productivity, and hence poverty reduction; c) diversification with a higher focus on crop-livestock development; d) innovative, cost effective and community based management of wastelands and common property resources; e) marketing, commercial orientation and competitiveness of dryland agriculture; and f)institutional innovations, building partnerships, linkages and capacity. The development of dryland agriculture requires synergy among technologies, marketing systems, input supplies, credit, policies and institutions. A broadbased sustainable growth and development in the drylands of Asia and sub-Saharan Africa is viewed as a key strategy for addressing rural poverty in the Asian and sub-Saharan region

Profiling of Plant Derived Natural Constituents by Using Magnetic Resonance Techniques

Plants are reservoirs of naturally occurring chemical constituents with a wide range of structural diversity. These biological compounds can be derived from different parts of plants such as leaves, barks, seeds, seed coats, flowers, and roots. A broad array of secondary metabolic compounds is present in the plants such as antibiotics, alkaloids, antimicrobials, food-grade pigments, and phenolics which have been reported to possess numerous health-related benefits, including antioxidant, anti-inflammatory, anticancer, and antiobesity activities. Therefore, the identification and detection of these compounds are of utmost importance in order to utilise their benefits into various fields. Wherein, magnetic resonance techniques, such as NMR (nuclear magnetic resonance), MRI (magnetic resonance imaging), and EPR (electron paramagnetic resonance), being far more reproducible, nondestructive, than other analytical techniques such as liquid chromatography, mass spectroscopy, and high-performance liquid chromatography cover a much wider dynamic range of metabolites with easy sample preparation techniques with high speed and fidelity. Hence, these magnetic resonance techniques have been proven to be extremely useful in plant metabolite profiling and disease metabolomics, along with structural elucidation of bioactive compounds from plant sources. Therefore, the present review focuses on the effectiveness of magnetic resonance for the detection of plant-derived metabolites that may lead to new areas of research in various fields such as drug discovery and development, metabolomics, combinatorial chemistry, and assessing overall food safety and quality

A Sensitive Search for Supernova Emission Associated with the Extremely Energetic and Nearby GRB 221009A

We report observations of the optical counterpart of the long gamma-ray burst (LGRB) GRB 221009A. Due to the extreme rarity of being both nearby ($z = 0.151$) and highly energetic ($E_{\gamma,\mathrm{iso}} \geq 10^{54}$ erg), GRB 221009A offers a unique opportunity to probe the connection between massive star core collapse and relativistic jet formation across a very broad range of $\gamma$-ray properties. Adopting a phenomenological power-law model for the afterglow and host galaxy estimates from high-resolution Hubble Space Telescope imaging, we use Bayesian model comparison techniques to determine the likelihood of an associated SN contributing excess flux to the optical light curve. Though not conclusive, we find moderate evidence ($K_{\rm{Bayes}}=10^{1.2}$) for the presence of an additional component arising from an associated supernova, SN 2022xiw, and find that it must be substantially fainter ($<$ 67% as bright at the 99% confidence interval) than SN 1998bw. Given the large and uncertain line-of-sight extinction, we attempt to constrain the supernova parameters ($M_{\mathrm{Ni}}$, $M_{\mathrm{ej}}$, and $E_{\mathrm{KE}}$) under several different assumptions with respect to the host galaxy's extinction. We find properties that are broadly consistent with previous GRB-associated SNe: $M_{\rm{Ni}}=0.05$ - $0.25 \, \rm{M_\odot}$, $M_{\rm{ej}}=3.5$ - $11.1 \, \rm{M_\odot}$, and $E_{\rm{KE}} = (1.6$ - $5.2) \times 10^{52} \, \rm{erg}$. We note that these properties are weakly constrained due to the faintness of the supernova with respect to the afterglow and host emission, but we do find a robust upper limit on the $M_{\rm{Ni}}$ of $M_{\rm{Ni}}<0.36\, \rm{M_\odot}$. Given the tremendous range in isotropic gamma-ray energy release exhibited by GRBs (7 orders of magnitude), the SN emission appears to be decoupled from the central engine in these systems.Comment: 18 pages, accepted to ApJL, 4 tables, 5 figures. Updated abstract in Previe

Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics

Cancer is an abnormal state of cells where they undergo uncontrolled proliferation and produce aggressive malignancies that cause millions of deaths every year. With the new understanding of the molecular mechanism(s) of disease progression, our knowledge about the disease is snowballing, leading to the evolution of many new therapeutic regimes and their successive trials. In the past few decades, various combinations of therapies have been proposed and are presently employed in the treatment of diverse cancers. Targeted drug therapy, immunotherapy, and personalized medicines are now largely being employed, which were not common a few years back. The field of cancer discoveries and therapeutics are evolving fast as cancer type-specific biomarkers are progressively being identified and several types of cancers are nowadays undergoing systematic therapies, extending patients’ disease-free survival thereafter. Although growing evidence shows that a systematic and targeted approach could be the future of cancer medicine, chemotherapy remains a largely opted therapeutic option despite its known side effects on the patient’s physical and psychological health. Chemotherapeutic agents/pharmaceuticals served a great purpose over the past few decades and have remained the frontline choice for advanced-stage malignancies where surgery and/or radiation therapy cannot be prescribed due to specific reasons. The present report succinctly reviews the existing and contemporary advancements in chemotherapy and assesses the status of the enrolled drugs/pharmaceuticals; it also comprehensively discusses the emerging role of specific/targeted therapeutic strategies that are presently being employed to achieve better clinical success/survival rate in cancer patients.All the authors are highly grateful and acknowledge to the authority of the respective departments and institutions for their support in carrying out this research. The authors also express their sincere gratitude to the unknown referee for critically reviewing the manuscript and suggesting useful changes. This research was funded by "Agencia Canaria de Investigación, Innovación y Sociedad de la Información (ACIISI) del Gobierno de Canarias” (No. ProID2020010134), and o´Caja Canarias (Project No. 2019SP43).Peer reviewe

Kilonova Luminosity Function Constraints Based on Zwicky Transient Facility Searches for 13 Neutron Star Merger Triggers during O3

We present a systematic search for optical counterparts to 13 gravitational wave (GW) triggers involving at least one neutron star during LIGO/Virgo's third observing run (O3). We searched binary neutron star (BNS) and neutron star black hole (NSBH) merger localizations with the Zwicky Transient Facility (ZTF) and undertook follow-up with the Global Relay of Observatories Watching Transients Happen (GROWTH) collaboration. The GW triggers had a median localization area of 4480 deg², a median distance of 267 Mpc, and false-alarm rates ranging from 1.5 to 10⁻²⁵ yr⁻¹. The ZTF coverage in the g and r bands had a median enclosed probability of 39%, median depth of 20.8 mag, and median time lag between merger and the start of observations of 1.5 hr. The O3 follow-up by the GROWTH team comprised 340 UltraViolet/Optical/InfraRed (UVOIR) photometric points, 64 OIR spectra, and three radio images using 17 different telescopes. We find no promising kilonovae (radioactivity-powered counterparts), and we show how to convert the upper limits to constrain the underlying kilonova luminosity function. Initially, we assume that all GW triggers are bona fide astrophysical events regardless of false-alarm rate and that kilonovae accompanying BNS and NSBH mergers are drawn from a common population; later, we relax these assumptions. Assuming that all kilonovae are at least as luminous as the discovery magnitude of GW170817 (−16.1 mag), we calculate that our joint probability of detecting zero kilonovae is only 4.2%. If we assume that all kilonovae are brighter than −16.6 mag (the extrapolated peak magnitude of GW170817) and fade at a rate of 1 mag day⁻¹ (similar to GW170817), the joint probability of zero detections is 7%. If we separate the NSBH and BNS populations based on the online classifications, the joint probability of zero detections, assuming all kilonovae are brighter than −16.6 mag, is 9.7% for NSBH and 7.9% for BNS mergers. Moreover, no more than 10⁻⁴, or φ > 30° to be consistent with our limits. We look forward to searches in the fourth GW observing run; even 17 neutron star mergers with only 50% coverage to a depth of −16 mag would constrain the maximum fraction of bright kilonovae to <25%

Prevalence of chronic kidney disease in South Asia: a systematic review

Background: Chronic kidney disease (CKD) is becoming a major public health problem around the world. But the prevalence has not been reported in South Asian region as a whole. This study aimed to systematically review the existing data from population based studies in this region to bridge this gap. Methods Articles published and reported prevalence of CKD according to K/DOQI practice guideline in eight South Asian countries between December 1955 and April 2017 were searched, screened and evaluated from seven electronic databases using the PRISMA checklist. CKD was defined as creatinine clearance (CrCl) or GFR less than 60 ml/min/1.73 m2. Results Sixteen population-based studies were found from four South Asian countries (India, Bangladesh, Pakistan and Nepal) that used eGFR to measure CKD. No study was available from Sri Lanka, Maldives, Bhutan and Afghanistan. Number of participants ranged from 301 in Pakistan to 12,271 in India. Majority of the studies focused solely on urban population. Different studies used different equations for measuring eGFR. The prevalence of CKD ranged from 10.6% in Nepal to 23.3% in Pakistan using MDRD equation. This prevalence was higher among older age group people. Equal number of studies reported high prevalence among male and female each. Conclusions This systematic review reported high prevalence of CKD in South Asian countries. The findings of this study will help pertinent stakeholders to prepare suitable policy and effective public health intervention in order to reduce the burden of this deadly disease in the most densely populated share of the globe