SEA LEVEL CHANGE ALONG THE TYRRHENIAN COAST FROM EARLY HOLOCENE TO THE PRESENT

In any discussion of the evolution of a river basin, the history of sealevel change is important since river gradients and delta developments are strongly influenced by local sea level. Also, sea level provides a reference for inferring past vertical tectonic stability from the geological record. Hence it is appropriate that the discussion on the Tiber basin starts with sea level change along the Tyrrhenian coast during the Holocene. The past evidence for sea level comes from inferences of the position of the sea surface with respect to the present. Hence it is a relative measure; a function of both the changing position of the ocean surface and of the land surface or an integrated measure of changes in ocean volume, land movement and redistribution of water within the ocean basins. The observation therefore contains information on all the processes that change these surfaces: on geophysical, glaciological and oceanographic processes

Pathophysiology of Gastric Ulcer Development and Healing: Molecular Mechanisms and Novel Therapeutic Options

Peptic ulcer disease is one of the most common chronic infections in human population. Despite centuries of study, it still troubles a lot of people, especially in the third world countries, and it can lead to other more serious complications such as cancers or even to death sometimes. This book is a snapshot of the current view of peptic ulcer disease. It includes 5 sections and 25 chapters contributed by researchers from 15 countries spread out in Africa, Asia, Europe, North America and South America. It covers the causes of the disease, epidemiology, pathophysiology, molecular-cellular mechanisms, clinical care, and alternative medicine. Each chapter provides a unique view. The book is not only for professionals, but also suitable for regular readers at all levels

New Archaeological Evidences of Relative Sea-level Changes along the Coastlines of Apulia (Southern Italy)

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The Effect of Sports Activities on Motor and Social Skills in Autistic Children and Adolescents: a Systematic Narrative Review

BackgroundThe main traits of Autism Spectrum Disorder (ASD) are difficulties in social communication and interactions. Autism is frequently related to motor impairments. In the last decades, to develop and promote the social and motor skills of autistic people, several sports training programmes have been designed. In the present systematic narrative review, we aimed at providing an overview of studies evaluating the effectiveness of these sports training programmes to synthesize their strengths and weaknesses.MethodTo formulate the eligibility criteria for the systematic review, the PICO protocol was used. The PRISMA protocol was applied to four databases for the search strategy. 30 papers were reviewed, and their main features were tabulated and critically discussed.ResultsFindings highlighted that 8 types of sports were applied to autistic individuals and that the majority of them were focused on two individual sports (i.e., swimming and horseback riding). In sum, findings revealed that sports training programmes provided positive benefits both on motor/social skills as well as on autistic traits (e.g., repetitive behaviours) and individual functioning. The narrative synthesis revealed also that future studies should enroll more autistic females and preschoolers. To encourage the social inclusion of autistic individuals, a group of typically developing peers should be involved in future sports training programmes.DiscussionIn conclusion, professionals trained on autistic traits and knowledgeable in the target sport are required; consultations with the autistic community as guidance for designing novel sports training programmes are recommended

Reply to comment by C. Morhange, C. Flaux, P. A. Pirazzoli, M. B. Carre on Holocene sea level change in Malta

The pits of Birzebbugia are located near the present-day mean sea level, and some are partially submerged. They were dated using pottery discovered in an archaeological site close to the coast, dated to the Bronze Age (Zammit, 1928; Abela, 1999). As they have been interpreted as sites for the retting of flax, during their utilization they should have remained dry and the sea could not submerge them. This is the reason why these structures are not directly related to the sea level, as suggested by Biolchi et al. (2011), so they represent an upper limit.peer-reviewe

Holocene sea level change in Malta

A multidisciplinary approach has been applied to study sea level changes along the coast of Malta using data collected from underwater archaeological remains. The elevation of archaeological markers have been compared with predicted sea level curves providing new bodies of evidence that outline the vertical tectonic behaviour of this region, allowing estimation of the relative sea level changes that occurred in this area of the Mediterranean since the Bronze Age. During the Roman Age, sea level was at −1.36 ± 0.1 m, while in the Midde Age it was at −0.56 ± 0.2 m, in agreement with previous estimations for the Mediterranean region. Data indicate that Malta was tectonically stable during the studied period. The occurrence of the present-day notch along the coasts of the island indicates recent vertical stability of the area. The lack of MIS 5.5 deposits all over the island could simply be due to high rates of erosion, as its coasts are highly exposed to storm waves, rather than tectonic movements. However, even very slight vertical movements could completely remove field evidence. The relative stability of the Maltese Islands allowed a first attempt to provide a palaeoenvironmental reconstruction of its coasts at different time windows since the Last Glacial Maximum. The results have been used to infer time and mode of mammal dispersal to the island during the Pleistocene.peer-reviewe

Reply to comment by C. Morhange, C. Flaux, P. A. Pirazzoli, M. B. Carre on Holocene sea level change in Malta

The pits of Birzebbugia are located near the present-day mean sea level, and some are partially submerged. They were dated using pottery discovered in an archaeological site close to the coast, dated to the Bronze Age (Zammit, 1928; Abela, 1999). As they have been interpreted as sites for the retting of flax, during their utilization they should have remained dry and the sea could not submerge them. This is the reason why these structures are not directly related to the sea level, as suggested by Biolchi et al. (2011), so they represent an upper limit.peer-reviewe

Neonatal Adaptation Issues After Maternal Exposure to Prescription Drugs: Withdrawal Syndromes and Residual Pharmacological Effects

Exposure to drugs during pregnancy has the potential to harm offspring. Teratogenic effects are the most feared adverse outcomes in newborns; however, a wide spectrum of less known, usually reversible and often acute, neonatal adverse events can also occur due to drug intake by mothers during pregnancy, particularly in close proximity to delivery. This narrative review is aimed at the description of drugs and drug classes for which licit maternal use in the predelivery period has been associated with neonatal non-teratogenic disorders. For each drug class, epidemiology, clinical features, biological mechanism and management of these adverse reactions have been discussed in detail. Although these adverse reactions have been described mainly for substances used illicitly for recreational purposes, several prescription drugs have also been involved; these include mainly psychotropic medications such as opioids, antidepressants, antiepileptics and antipsychotics. These effects can be partly explained by withdrawal syndromes (defined also as 'neonatal abstinence syndrome') caused by the delivery-related discontinuation of the drug disposition from the mother to the fetus, with symptoms that may include feeding disorders, tremors, irritability, hypotonia/hypertonia, vomiting and persistent crying, occurring a few hours to 1 month after delivery. Otherwise, neonatal neurological and behavioral effects can also be caused by a residual pharmacological effect due to an accumulation of the drug in the blood and tissues of the newborn, with various symptoms related to the toxic effects of the specific drug class, usually developing a few hours after birth. With few exceptions, validated protocols for the assessment and management of withdrawal or residual pharmacological effects of these drugs in neonates are often lacking or incomplete. Spontaneous reporting of these adverse reactions seems limited, although it might represent a useful tool for improving our knowledge about drug-induced neonatal syndromes

Hydroxyurea in essential thrombocythemia: rate and clinical relevance of responses by European LeukemiaNet criteria

Abstract A definition of response by cytoreductive therapy in essential thrombocythemia was recently provided by the European LeukemiaNet (ELN). Complete, partial, or no clinicohematologic responses were defined on the bases of platelet count, disease-related symptoms, spleen size, and white blood cell count. To provide estimates and clinical correlation of responses according to these criteria, we retrospectively examined 416 essential thrombocythemia patients treated with hydroxyurea for at least 12 months. Complete response, partial response, and no response were 25%, 58%, and 17%, respectively. Age more than 60 years and JAK2V617F mutation were significant predictors of response. After a median follow-up of 3.9 years, we registered 23 deaths, 16 hematologic transformations, and 27 thrombotic events (rate, 1.66% patients/year). Age, previous thrombosis, leukocytosis (white blood cell count > 10 × 109/L), but not ELN responses, were independently associated with higher risk of thrombosis. The actuarial probability of thrombosis was significantly influenced by leukocytosis (P = .017) and not by platelet count, indicating that platelet number does not seem of prime relevance in the definition of ELN response