86 research outputs found

    Proton dynamics in cancer

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    Cancer remains a leading cause of death in the world today. Despite decades of research to identify novel therapeutic approaches, durable regressions of metastatic disease are still scanty and survival benefits often negligible. While the current strategy is mostly converging on target-therapies aimed at selectively affecting altered molecular pathways in tumor cells, evidences are in parallel pointing to cell metabolism as a potential Achilles' heel of cancer, to be disrupted for achieving therapeutic benefit. Critical differences in the metabolism of tumor versus normal cells, which include abnormal glycolysis, high lactic acid production, protons accumulation and reversed intra-extracellular pH gradients, make tumor site a hostile microenvironment where only cancer cells can proliferate and survive. Inhibiting these pathways by blocking proton pumps and transporters may deprive cancer cells of a key mechanism of detoxification and thus represent a novel strategy for a pleiotropic and multifaceted suppression of cancer cell growth

    Back to social classes?

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    Alongside a literature that considers the reference to social classes to be misleading, there has been a recent debate on the persisting importance of social classes in sociological explanation. This debate has brought interesting empirical results, but has also put into question the traditional schemes of classes that have been used since the 1980s.The diminishing ability of the variable ‘class’ to explain a large part of social phenomena is not due to the disappearance of classes, but to the inability of the traditional schemes to reflect the emerging aspects of the structure, which continue to perform their central role in explaining social inequalities. The article identifies and discuss the most important of these emerging aspects and their implication for the proposal of new empirical schemes

    Presentazione

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    Il termine «capitale sociale» vive un periodo di successo nel dibattito sociologico nazionale ed internazionale, sull’onda di articoli pubblicati su riviste come «American Journal of Sociology», «American Sociological Review», «British Journal of Sociology», «European Sociological Review», «The Annual Review of Sociology», «Theory & Society» e sulla base dell’interesse mostrato da istituzioni internazionali come la World Bank, l’oecd e l’ilo. In Italia il dibattito è stato avviato da recenti ..

    Presentazione

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    A distanza di otto anni dallo scoppio della grande crisi del nuovo secolo, le risposte dei paesi coinvolti appaiono molto diverse. Gli Stati Uniti, da cui la crisi ha preso le mosse, sono stati più veloci ad uscirne, grazie ad un fortissimo intervento pubblico di bailout, restituito con gli interessi dalle aziende salvate entro il 2012. La crisi continua tuttavia ad esercitare effetti depressivi sulla maggior parte dei paesi occidentali e sui paesi ricchi di materie prime, a causa della cadut..

    Modelli di capitalismo

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    Familismo amorale e capitale sociale

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    The concept of «amoral familism», as introduced by Edward C. Banfield for explaining the backwardness of Southern Italy, has provoked many criticisms since the publication of his book «The Moral Basis of a Backward Society» (Italian edition 1961). Nonetheless, this concept has been used by several scholars for identifying a specific form of social structure, based on a strong family cohesion, a relatively weak civil society and distrust of the state. The article discusses the reasons underlying the success and influence of Banfield’s book and focuses on certain limitations of its analysis, with special reference to its deficiency at the analytical and theoretical level
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