Results of intensive phase tretament of tuberculosis treatment according to CYP2E1 genotype

The polymorphism of the gene of cytochrome P-450 2E1 (CYP2E1) that participate in metabolism of antituberculosis agent isoniazid may influence on effectiveness of tuberculosis (TB) treatment. Aim of research: to detect the peculiarities of pulmonary TB course and outcome after in -patient treatment according to CYP2E1 genotype of the patients with primary TB. Materials and methods: analysis of medical cards from 86 patients with primary pulmonary tuberculosis at the end of hospital treatment in Odessa regional antituberculosal dispensary was conducted in 2012 year with consideration of CYP2E1 genotype. Results: the obtained data has proved that at the beginning of treatment there was no significant difference between TB patients concerning the signs of destruction, infiltration and disintegration according to CYP2E1 polymorphism, however the patients with CD, DD genotype more frequently had sings of dissemination and destruction in pulmonary tissues than the patients with CC genotype. At the end of in-patient treatment the patients with CD, DD genotype more often exhibited signs of infiltration of pulmonary tissues and longer remained smear-positive according to cultural method, than the patients with CC genotype. Despite of CYP2E1 genotype around 25% of tuberculosis patients had multidrug resistant strains of M.tuberculosis in the end of in-patient treatment. It will be important to check in coming researches an influence of CYP2E1 polymorphism in TB-patients on toxicity of antituberculosis therapy

Critical exponents for 3D O(n)-symmetric model with n > 3

Critical exponents for the 3D O(n)-symmetric model with n > 3 are estimated on the base of six-loop renormalization-group (RG) expansions. A simple Pade-Borel technique is used for the resummation of the RG series and the Pade approximants [L/1] are shown to give rather good numerical results for all calculated quantities. For large n, the fixed point location g_c and the critical exponents are also determined directly from six-loop expansions without addressing the resummation procedure. An analysis of the numbers obtained shows that resummation becomes unnecessary when n exceeds 28 provided an accuracy of about 0.01 is adopted as satisfactory for g_c and critical exponents. Further, results of the calculations performed are used to estimate the numerical accuracy of the 1/n-expansion. The same value n = 28 is shown to play the role of the lower boundary of the domain where this approximation provides high-precision estimates for the critical exponents.Comment: 10 pages, TeX, no figure

Critical behavior of frustrated systems: Monte Carlo simulations versus Renormalization Group

We study the critical behavior of frustrated systems by means of Pade-Borel resummed three-loop renormalization-group expansions and numerical Monte Carlo simulations. Amazingly, for six-component spins where the transition is second order, both approaches disagree. This unusual situation is analyzed both from the point of view of the convergence of the resummed series and from the possible relevance of non perturbative effects.Comment: RevTex, 10 pages, 3 Postscript figure

Critical behavior of three-dimensional magnets with complicated ordering from three-loop renormalization-group expansions

The critical behavior of a model describing phase transitions in 3D antiferromagnets with 2N-component real order parameters is studied within the renormalization-group (RG) approach. The RG functions are calculated in the three-loop order and resummed by the generalized Pade-Borel procedure preserving the specific symmetry properties of the model. An anisotropic stable fixed point is found to exist in the RG flow diagram for N > 1 and lies near the Bose fixed point; corresponding critical exponents are close to those of the XY model. The accuracy of the results obtained is discussed and estimated.Comment: 10 pages, LaTeX, revised version published in Phys. Rev.

Monte Carlo renormalization group study of the Heisenberg and XY antiferromagnet on the stacked triangular lattice and the chiral ϕ4\phi^4 model

With the help of the improved Monte Carlo renormalization-group scheme, we numerically investigate the renormalization group flow of the antiferromagnetic Heisenberg and XY spin model on the stacked triangular lattice (STA-model) and its effective Hamiltonian, 2N-component chiral $\phi^4$ model which is used in the field-theoretical studies. We find that the XY-STA model with the lattice size $126\times 144 \times 126$ exhibits clear first-order behavior. We also find that the renormalization-group flow of STA model is well reproduced by the chiral $\phi^4$ model, and that there are no chiral fixed point of renormalization-group flow for N=2 and 3 cases. This result indicates that the Heisenberg-STA model also undergoes first-order transition.Comment: v1:15 pages, 15 figures v2:updated references v3:added comments on the higher order irrelevant scaling variables v4:added results of larger sizes v5:final version to appear in J.Phys.Soc.Jpn Vol.72, No.

Towards exotic nuclei via binary reaction mechanism

Assuming a binary reaction mechanism, the yield of isotopes near the heaviest $N=Z$ neutron-deficit nucleus $^{100}$Sn is studied with a microscopic transport model. The large influence of nuclear shell structure and isotope composition of the colliding nuclei on the production of exotic nuclei is demonstrated. It is shown that the reaction $^{54}$Fe+$^{106}$Cd seems to be most favourable for producing primary exotic Sn isotopes which may survive if the excitation energy in the entrance reaction channel is less than about 100 MeV. In the case of large differences in the charge (mass) numbers between entrance and exit channels the light fragment yield is essentially fed from the decay of excited primary heavier fragments. The existence of optimal energies for the production of some oxygen isotopes in the binary mechanism is demonstrated for the $^{32}$S+$^{197}$Au reaction.Comment: 17 pages, RevTex, 8 Postscript figures, submitted to Phys. Rev.

Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritis.

DNAX adaptor protein 12 (DAP12) is a trans-membrane adaptor molecule that transduces activating signals in NK and myeloid cells. Absence of functional Dap12 results in osteoclast defects and bone abnormalities. Because DAP12 has no extracelluar binding domains, it must pair with cell surface receptors for signal transduction. There are at least 15 known DAP12-associating cell surface receptors with distinct temporal and cell type-specific expression patterns. Our aim was to determine which receptors may be important in DAP12-associated bone pathologies. Here, we identify myeloid DAP12-associating lectin (MDL)-1 receptor (also known as CLEC5A) as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation. Activation of MDL-1 leads to enhanced recruitment of inflammatory macrophages and neutrophils to the joint and promotes bone erosion. Functional blockade of MDL-1 receptor via Mdl1 deletion or treatment with MDL-1-Ig fusion protein reduces the clinical signs of autoimmune joint inflammation. These findings suggest that MDL-1 receptor may be a therapeutic target for treatment of immune-mediated skeletal disorders