I sistemi di Business Intelligence e il coordinamento organizzativo.

Il coordinamento. I costi del coordinamento. Le tecnologie di coordinamento. La Business Intelligence. La ricerca.Il coordinamento. I costi del coordinamento. Le tecnologie di coordinamento. La Business Intelligence. La ricerca.LUISS PhD Thesi

I sistemi di Business Intelligence e il coordinamento organizzativo.

Il coordinamento. I costi del coordinamento. Le tecnologie di coordinamento. La Business Intelligence. La ricerca

Il Modello di organizzazione, gestione e controllo ex D.lgs. 231/2001. Nuove prospettive di compliance in chiave 4.0

Il D.lgs. 231/2001 ha introdotto nell’ordinamento giuridico italiano, la Responsabilità amministrativa degli enti. L’ente, dunque, potrebbe assumere il ruolo di indagato, imputato e condannato nel procedimento penale instaurato, laddove all’interno della propria organizzazione, nell’interesse o a vantaggio della stessa, venisse commesso un illecito rilevante ai fini della normativa. Al fine di tutelare l’Ente, lo stesso decreto ha individuato uno strumento che assurge ad esimente dalla responsabilità: il Modello di organizzazione, gestione e controllo utile al fine di ridurre il rischio di commissione dei cd. Reati presupposto e di dotare l’Ente di un’efficiente organizzazione. Tuttavia, affinché il Modello possa assolvere alla sua funzione esimente, è necessario che sia adeguato, idoneo ed efficace. L’obiettivo di questo studio è pertanto quello di individuare una metodologia che possa porsi a garanzia di adeguatezza del Modello. La domanda di ricerca è la seguente: si può ideare un metodo per la costruzione di un Modello standard, ma personalizzabile in grado di integrare tutti i requisiti richiesti dal D.lgs. 231/2001 ai fini dell’esimente e divenire al contempo parametro di giudizio di idoneità? Il progetto di ricerca “Il Modello di organizzazione, gestione e controllo ex D.lgs. 231/2001. Nuove prospettive di compliance in chiave 4.0” si pone infatti come obiettivo quello di dimostrare l’importanza dell’adozione di un adeguato Modello di organizzazione, gestione e controllo da parte del management aziendale, e a partire dal concetto di suitability, di fornire un’interpretazione in chiave 4.0, dei sistemi di gestione che, dall’impatto con la digitalizzazione, riusciranno ad innescare un circolo virtuoso in grado di dare dimostrazione dell’adeguatezza, dell’idoneità, dell’effettiva attuazione di un determinato Sistema 231. La ricerca può suddividersi in tre aree, che prendono le mosse dallo studio della normativa di riferimento e di quelle ad essa connesse e dallo studio sul campo della consulenza. La prima area di ricerca è dedicata alla disamina del D.lgs. 231/2001 e della cd. Responsabilità amministrativa degli enti. Viene illustrato il Modello di organizzazione, gestione e controllo del quale si analizzeranno principi, struttura e fasi di costruzione. Dai concetti di organizzazione e gestione manageriale si passerà dunque al fondamentale concetto del controllo che in un Sistema 231 è rappresentato dall’Organismo di Vigilanza. Di tale figura cardine sono descritti i compiti, le funzioni e le attività poste a garanzia dell’adeguatezza e dell’effettiva ed efficace attuazione del Modello 231. La seconda area di ricerca è dedicata alla compliance aziendale realizzata attraverso i sistemi di gestione integrata ed è finalizzata a evidenziare come un sistema di compliance integrato, permettendo all’ente la razionalizzazione di tutti i processi aziendali, sensibili non solo a livello 231 ma di ogni normativa d’interesse, crei un modello organizzativo adeguato alla struttura di riferimento. Verranno pertanto analizzate le connessioni tra MOGC231 e le normative ISO. La terza area di ricerca, infine, è dedicata alla tematica 4.0 e, nello specifico, a come l’impatto della digitalizzazione possa offrire nuove prospettive di suitability dei Sistemi 231. A partire dalla sentenza Impregilo e di quanto statuisce a proposito di adeguatezza, pertanto si cerca di illustrare come la digitalizzazione del MOGC231, attraverso l’uso di gestionali, possa diventare paradigma di adeguatezza. Verrà dunque presentato il progetto di Aspera231 Srl relativo alla progettazione del software 231inCloud. A conclusione, si presenta il caso di un’azienda modello.The Legislative Decree 231/2001 introduced the administrative liability of entities into the Italian legal system. The entity, therefore, could assume the role of suspect, accused and convicted in the criminal proceedings initiated, where within its organization, in the interest or to the advantage of the same, an offense relevant for the purposes of the legislation was committed. In order to protect the organisation, the same decree has identified a tool that exempts it from liability: the Organisation, Management and Control Model useful for reducing the risk of commission of the so-called. Predicate crimes and to provide the organization with an efficient organisation. However, in order for the Model to fulfill its exempting function, it must be adequate, suitable and effective. The objective of this study is therefore to identify a methodology that can act as a guarantee of the adequacy of the Model. The research question is the following: can a method be devised for the construction of a standard but customizable Model capable of integrating all the requirements required by the Legislative Decree. 231/2001 for the purposes of exemption and at the same time become a parameter for judging suitability? The research project “The organisation, management and control model pursuant to Legislative Decree. 231/2001. New perspectives of compliance from a 4.0 perspective" aims in fact to demonstrate the importance of adopting an adequate organisation, management and control model by company management, and starting from the concept of suitability, to provide an interpretation in a 4.0 key, management systems which, from the impact with digitalisation, will be able to trigger a virtuous circle capable of demonstrating the adequacy, suitability and effective implementation of a specific 231 System. The research can be divided into three areas, which start from the study of the reference legislation and those connected to it and from the study in the field of consultancy. The first research area is dedicated to the examination of the Legislative Decree. 231/2001 and the so-called. Administrative responsibility of institutions. The organisation, management and control model is illustrated, the principles, structure and construction phases of which will be analysed. From the concepts of organization and managerial management we will therefore move on to the fundamental concept of control which in a 231 System is represented by the Organismo di Vigilanza (supervisor body). The tasks, functions and activities of this key figure are described to guarantee the adequacy and effective and effective implementation of Model 231. The second area of research is dedicated to corporate compliance achieved through integrated management systems and is aimed at highlighting how an integrated compliance system, allowing the organization to rationalize all corporate processes, sensitive not only at the 231 level but of every legislation of interest, creates an organizational model suited to the reference structure. The connections between MOGC231 and ISO standards will therefore be analysed. Finally, the third research area is dedicated to the 4.0 topic and, specifically, to how the impact of digitalisation can offer new prospects for suitability of 231 Systems. Starting from the Impregilo ruling and what it rules regarding adequacy, therefore we try to illustrate how the digitalization of MOGC231, through the use of management software, can become a paradigm of adequacy. The Aspera231 Srl project relating to the design of the 231inCloud software will therefore be presented. In conclusion, the case of a model company is presented

Environmental Impact of Fused Filament Fabrication: What Is Known from Life Cycle Assessment?

This systematic review interrogates the literature to understand what is known about the environmental sustainability of fused filament fabrication, FFF (also known as fused deposition modeling, FDM), based on life cycle assessment (LCA) results. Since substantial energy demand is systematically addressed as one of the main reasons for ecological damage in FFF, mitigation strategies are often based on reducing the printing time (for example, adopting thicker layers) or the embodied energy per part (e.g., by nesting, which means by printing multiple parts in the same job). A key parameter is the infill degree, which can be adjusted to the application requirements while saving printing time/energy and feedstock material. The adoption of electricity from renewable resources is also expected to boost the sustainability of distributed manufacturing through FFF. Meanwhile, bio-based and recycled materials are being investigated as less impactful alternatives to conventional fossil fuel-based thermoplastic filaments

Caduta accidentale di una paziente sottoposta a riduzione chirurgica di frattura di femore: analisi delle cause profonde

Introduction. Inpatient falls in hospital is a relevant problem. The first essential step is to know the risks to prevent them, through reactive or proactive analysis. In this study we used the Root Causes Analysis (RCA) to analyze an accidental fall of a 79-year-old patient after a surgical intervention for a femoral fracture. The aim of the analysis is to evaluate the effect of this method on sanitary professionals. Material and methods. The study was conducted at the Operative Unity of Orthopaedics and Traumatology, “Beato Matteo Institute”, Vigevano. RCA was realised in the following steps: creation of the team, individuation of the causes, collection and evaluation of the information, identification of the solutions and the proposals of improvement. Results. The RCA showed the following causes: incomplete assessment of the patient, lacking professional skills, lacking of procedures and safety systems, risk factors connected both to the patient and the environment. The improvement proposals were: education and information of professionals, education of patient and caregivers, nursing interventions, environmental strategies and signalling systems. Discussion. RCA is an useful tool for risk management and it allowed to highlight causes and corrective actions of the accidental fall. Furthermore, this case allowed to underline advantages and disadvantages of this method. Advantages were the involvement of different professionals and sharing of objectives of systems improvement; the importance of the introduction of new instruments for risks identification and specific education to use them. Among the disadvantages we can list: difficulties in finding all the informations to correctly analyse the case, perception of too much bureaucracy in the procedure, and fear of a “punitive” use of the information collected

Modelling shortwave and longwave downward radiation and air temperature driving ablation at the Forni Glacier (Stelvio National Park, Italy)

We focus here on modelling the meteorological parameters most influencing snow/ice melting over an alpine glacier. Specifically, we consider shortwave and longwave downward radiation, and air temperature. We set up and test a methodology for their accurate distribution at the glacier surface, which can be applied whenever: i) supraglacial meteoro-logical measurements are available or ii) weather data are acquired from a station quite close to the glacier. As a suitable site to test our approach we selected the Forni Glacier, in the Italian Alps, where an Automatic Weather Station (AWS) has been running since autumn 2005 thus giving a robust dataset for developing a field based modeling approach. First, we modelled and distributed the incoming solar radiation by taking into account actual atmospheric conditions, glacier topography and shading. Then, we modelled the incoming longwave radiation considering cloud-cover and air temperature. Third, we investigated a local lapse rate to depict the yearly variability of the vertical air temperature gradient, to assess the actual thermal conditions at different elevations. Finally, we compared the modeled values against data collected on the field. The results display that during the glacier ablation period (i.e.: May-September): i) our approach provides a good depiction of both point incoming solar and infrared radiation fluxes, ii) the spatial distribution of the incoming solar radiation we developed is satisfactory, iii) our tests suggest that the incoming longwave fluxes can be considered constant over the whole glacier ablation area thus neglecting its spatial distribution, and iv) the application of a local lapse rate provides a good distribution of air temperature at the glacier surface

Lotus Birth Associated With Idiopathic Neonatal Hepatitis

In the present case, the infant presented with a complication of LB. There was a close temporal relationship between LB and the onset of clinical symptoms. The baby had persistent jaundice associated with a severe increase in aspartate and alanine aminotransferases without evidence of cholestasis. Recovery occurred spontaneously after the first months of life. Hepatobiliary, hematological, metabolic, endocrine, and genetic disorders were ruled out

The GATA1-HS2 Enhancer Allows Persistent and Position-Independent Expression of a β-globin Transgene

Gene therapy of genetic diseases requires persistent and position-independent expression of a therapeutic transgene. Transcriptional enhancers binding chromatin-remodeling and modifying complexes may play a role in shielding transgenes from repressive chromatin effects. We tested the activity of the HS2 enhancer of the GATA1 gene in protecting the expression of a β-globin minigene delivered by a lentiviral vector in hematopoietic stem/progenitor cells. Gene expression from proviruses carrying GATA1-HS2 in both LTRs was persistent and resistant to silencing at most integration sites in the in vivo progeny of human hematopoietic progenitors and murine long-term repopulating stem cells. The GATA1-HS2-modified vector allowed correction of murine β-thalassemia at low copy number without inducing clonal selection of erythroblastic progenitors. Chromatin immunoprecipitation studies showed that GATA1 and the CBP acetyltransferase bind to GATA1-HS2, significantly increasing CBP-specific histone acetylations at the LTRs and β-globin promoter. Recruitment of CBP by the LTRs thus establishes an open chromatin domain encompassing the entire provirus, and increases the therapeutic efficacy of β-globin gene transfer by reducing expression variegation and epigenetic silencing

Production and characterization of CSSI003 (2961) human induced pluripotent stem cells (iPSCs) carrying a novel puntiform mutation in RAI1 gene, Causative of Smith–Magenis syndrome

Smith-Magenis syndrome (SMS) is a complex genetic disorder characterized by developmental delay, behavioural problems and circadian rhythm dysregulation. About 90% of SMS cases are due to a 17p11.2 deletion containing retinoic acid induced1 (RAI1) gene, 10% are due to heterozygousmutations affecting RAI1 coding region. Little is known about RAI1 role