Excess portal venous long-chain fatty acids induce syndrome X via HPA axis and sympathetic activation

We tested the hypothesis that excessive portal venous supply of long-chain fatty acids to the liver contributes to the development of insulin resistance via activation of the hypothalamus-pituitary-adrenal axis (HPA axis) and sympathetic system. Rats received an intraportal infusion of the long-chain fatty acid oleate (150 nmol/min, 24 h), the medium-chain fatty acid caprylate, or the solvent. Corticosterone (Cort) and norepinephrine (NE) were measured as indexes for HPA axis and sympathetic activity, respectively. Insulin sensitivity was assessed by means of an intravenous glucose tolerance test (IVGTT). Oleate infusion induced increases in plasma Cort (Δ = 13.5 ± 3.6 µg/dl; P < 0.05) and NE (Δ = 235 ± 76 ng/l; P < 0.05), whereas caprylate and solvent had no effect. The area under the insulin response curve to the IVGTT was larger in the oleate-treated group than in the caprylate and solvent groups (area = 220 ± 35 vs. 112 ± 13 and 106 ± 8, respectively, P < 0.05). The area under the glucose response curves was comparable [area = 121 ± 13 (oleate) vs. 135 ± 20 (caprylate) and 96 ± 11 (solvent)]. The results are consistent with the concept that increased portal free fatty acid is involved in the induction of visceral obesity-related insulin resistance via activation of the HPA axis and sympathetic system.

Further development of a charged liquid colloid source for electrostatic propulsion Final report

Performance characteristics of charged liquid droplet electrostatic propulsion syste

Europium nitride: A novel diluted magnetic semiconductor

Europium nitride is semiconducting and contains non-magnetic \3+, but sub-stoichiometric EuN has Eu in a mix of 2+ and 3+ charge states. We show that at \2+ ~concentrations near 15-20% EuN is ferromagnetic with a Curie temperature as high as 120 K. The \3+ ~polarization follows that of the \2+, confirming that the ferromagnetism is intrinsic to the EuN which is thus a novel diluted magnetic semiconductor. Transport measurements shed light on the likely exchange mechanisms.Comment: 5 page

Experimental evaluation of electrostatic generator configurations final report

Evaluation of electrostatic generator design in atmospheric pressur

On the origin of exponential growth in induced earthquakes in Groningen

The Groningen gas field shows exponential growth in earthquakes event counts around a magnitude M1 with a doubling time of 6-9 years since 2001. This behavior is identified with dimensionless curvature in land subsidence, which has been evolving at a constant rate over the last few decades {essentially uncorrelated to gas production.} We demonstrate our mechanism by a tabletop crack formation experiment. The observed skewed distribution of event magnitudes is matched by that of maxima of event clusters with a normal distribution. It predicts about one event $<$\,M5 per day in 2025, pointing to increasing stress to human living conditions.Comment: 12 pages, 7 figures, to appear in Earthquakes and Structure

3D image of Inoue balloon inflation during mitral valvuloplasty

Mitral balloon valvuloplasty is an important intervention in the armory of the cardiologist, offering a safe and effective percutaneous option in the treatment of patients with mitral stenosis

Latent Causal Socioeconomic Health Index

This research develops a model-based LAtent Causal Socioeconomic Health (LACSH) index at the national level. We build upon the latent health factor index (LHFI) approach that has been used to assess the unobservable ecological/ecosystem health. This framework integratively models the relationship between metrics, the latent health, and the covariates that drive the notion of health. In this paper, the LHFI structure is integrated with spatial modeling and statistical causal modeling, so as to evaluate the impact of a continuous policy variable (mandatory maternity leave days and government's expenditure on healthcare, respectively) on a nation's socioeconomic health, while formally accounting for spatial dependency among the nations. A novel visualization technique for evaluating covariate balance is also introduced for the case of a continuous policy (treatment) variable. We apply our LACSH model to countries around the world using data on various metrics and potential covariates pertaining to different aspects of societal health. The approach is structured in a Bayesian hierarchical framework and results are obtained by Markov chain Monte Carlo techniques.Comment: 31 pages. arXiv admin note: substantial text overlap with arXiv:1911.0051