Reluctant Cross-Metathesis Reactions: The Highly Beneficial Effect of Microwave Irradiation

carbene complexes ; catalysis ; cross coupling ; metathesis ; olefinationInternational audienceThe beneficial effect of microwave irradiation versus classical thermal conditions is demonstrated through a series of comparative cross-metathesis reactions

Relevance of Second Harmonic Generation Microscopy (SHG-M) in Material Sciences

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Combined Influences of Gm and HLA Phenotypes upon Multiple Sclerosis Susceptibility and Severity

In some Caucasian populations, multiple sclerosis (MS) susceptibility has been independently related to given alleles of HLA or Gm systems that respectively code for major histocompatibility complex class I and II antigens or immunoglobulin G heavy chains. Whether given combinations of alleles at both series of loci simultaneously influence MS susceptibility and/or severity was investigated by comparing 147 French MS patients and 226 geographically-matched healthy controls. The G2m(-23)/HLA-B35 phenotype and Glm(-1)/HLA-B7(-)/HLA-DR2 phenotype were respectively associated with significant protection against (relative risk = 0.05) and susceptibility to (relative risk = 4.3) MS. When considering MS severity, the presence of HLA-B7 antigen correlated with a more severe disease in Gm1/Gm3 heterozygous patients, but not in Gm3/Gm3 homozygous patients. Conversely, an HLA-B12-associated milder disease was restricted to Gm3/Gm3 homozygotes. These results demonstrate the combined influence on MS of genetic loci that are unlinked but immune response-associated. Combined Gm and HLA typing is very likely able to serve as a prognostic indicator in this disease

Apport des diagrammes de phases dans l’ultrapurification des molécules organiques : cas du phénanthrène

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Apport des diagrammes de phases dans l’ultrapurification des molécules organiques : cas du phénanthrène

International audienc

Relevance of Second Harmonic Generation Microscopy (SHG-M) in Material Sciences

International audienc

Second Harmonic Generation Microscopy (SHG-M) to Monitor Phase Transitions in Disordered Organic Crystals

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