Mechanical Characterization of Torsional Micropaddles Using Atomic Force Microscopy

The reference cantilever method is shown to act as a direct and simple method for determination of torsional spring constant. It has been applied to the characterization of micropaddle structures similar to those proposed for resonant functionalized chemical sensors and resonant thermal detectors. It is shown that this method can be used as an effective procedure to characterize a key parameter of these devices and would be applicable to characterization of other similar MEMS/NEMS devices such as micromirrors. In this study, two sets of micropaddles are manufactured (beams at centre and offset by 2.5 μm) by using LPCVD silicon nitride as a substrate. The patterning is made by direct milling using focused ion beam. The torsional spring constant is achieved through micromechanical analysis via atomic force microscopy. To obtain the gradient of force curve, the area of the micropaddle is scanned and the behaviour of each pixel is investigated through an automated developed code. The experimental results are in a good agreement with theoretical results

Equilibration of quantum systems and subsystems

We unify two recent results concerning equilibration in quantum theory. We first generalise a proof of Reimann [PRL 101,190403 (2008)], that the expectation value of 'realistic' quantum observables will equilibrate under very general conditions, and discuss its implications for the equilibration of quantum systems. We then use this to re-derive an independent result of Linden et. al. [PRE 79, 061103 (2009)], showing that small subsystems generically evolve to an approximately static equilibrium state. Finally, we consider subspaces in which all initial states effectively equilibrate to the same state.Comment: 5 page

Numerical calibration of the stable poisson loaded specimen

An analytical calibration of the Stable Poisson Loaded (SPL) specimen is presented. The specimen configuration is similar to the ASTM E-561 compact-tension specimen with displacement controlled wedge loading used for R-Curve determination. The crack mouth opening displacements (CMOD's) are produced by the diametral expansion of an axially compressed cylindrical pin located in the wake of a machined notch. Due to the unusual loading configuration, a three-dimensional finite element analysis was performed with gap elements simulating the contact between the pin and specimen. In this report, stress intensity factors, CMOD's, and crack displacement profiles are reported for different crack lengths and different contacting conditions. It was concluded that the computed stress intensity factor decreases sharply with increasing crack length, thus making the SPL specimen configuration attractive for fracture testing of brittle, high modulus materials

Correlated forward-backward dissociation and neutron spectra as a luminosity monitor in heavy ion colliders

Detection in zero degree calorimeters of the correlated forward-backward Coulomb or nuclear dissociation of two colliding nuclei is presented as a practical luminosity monitor in heavy ion colliders. Complementary predictions are given for total correlated Coulomb plus nuclear dissociation and for correlated forward-backward single neutrons from the giant dipole peak.Comment: 16 pages, latex, revtex source, four postscript figure

The seed and agricultural biotechnology industries in India: An analysis of industry structure, competition, and policy options

Since the late 1980s, technological advances and policy reforms have opened up new opportunities for growth in India's seed and agricultural biotechnology industries. The impacts of such changes have been significant in India's cotton sector, but less so for the country's main cereal crops, where both yield and output growth rates have been relatively stagnant. Some public policymakers and corporate decisionmakers are confident that the private sector will help reverse these trends, arguing that the right combination of new technological solutions and progressive policy reforms will unleash a significant increase in private investment in productivity-enhancing products and services. The structure of India's seed and agbiotech industries, as well as the policies designed to support their growth, will be a significant determinant of this expected impact. This paper examines the structure of India's cereal seed and agbiotech industries, its potential effects on innovation and social welfare, and the policies that may improve both industry performance and the delivery of new technologies to resource-poor, small-scale farmers in India's cereal production systems. We focus our analysis on indicators and scenarios within India's agricultural innovation market for improved seed and agricultural biotechnology products. This market includes firms engaged in the development, commercialization, and marketing of new seed-based technologies; it is characterized by a high level of knowledge intensity, relatively high levels of R&D investment, significant barriers to entry, significant levels of regulation, and relatively few products in the market. And it is within this market that factors such as strategic corporate behavior and public policy can affect the balance between a socially desirable rate of innovation, on the one hand, and a socially desirable distribution of the gains from innovation among consumers, farmers, and innovators, on the other hand.Seed markets, Agricultural biotechnology, industrial organization, Cereal crops,

A Case of Statin-Associated Autoimmune Myopathy.

A 70-year-old previously independent man developed progressive proximal leg weakness resulting in a fall at home suffering traumatic brain injury. He was prescribed a statin medication two years prior, but this was discontinued on admission to the hospital due to concern for statin myopathy. His weakness continued to progress while in acute rehabilitation, along with the development of dysphagia requiring placement of gastrostomy tube and respiratory failure requiring tracheostomy. Corticosteroids and intravenous immunoglobulin were administered without response. Nerve conduction study demonstrated no evidence of neuropathy; electromyography revealed spontaneous activity suggestive of myopathy. A muscle biopsy was performed and demonstrated myonecrosis. Serology was positive for autoantibodies to 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), verifying our diagnosis of statin-associated autoimmune myopathy (SAM). The patient was subsequently treated with rituximab and methotrexate and demonstrated mild clinical improvement. He was eventually liberated from the ventilator. However, later in the course of treatment, he developed respiratory distress and required ventilator support. The patient was discharged to long-term acute care two months after his initial presentation and died due to ventilator-acquired pneumonia three months later. Since their introduction 30 years ago, statin medications have been widely prescribed to prevent cardiovascular diseases. Myalgias and/or myopathic symptoms are among the most recognized side effects of the medication. Statin-associated autoimmune myopathy is a very rare complication of statin use and estimated to affect two to three for every 100,000 patients treated. Clinically, the condition presents as progressive symmetric weakness, muscle enzyme elevations, necrotizing myopathy on muscle biopsy, and the presence of autoantibodies to HMGCR. These findings will often persist and even progress despite discontinuation of the statin. Very few cases of SAM have been described in the literature. Describing this rare condition and the ultimately fatal outcome of our patient, we aim to further understanding of SAM, its presentation and clinical course to promote earlier diagnosis and prompt management

Arthroscopic Anterior Shoulder Stabilization With Incorporation of a Comminuted Bony Bankart Lesion.

Bony Bankart lesions are a common finding in patients with anterior glenohumeral dislocation. Although there are no defined guidelines, small bony Bankart fractures are typically treated arthroscopically with suture anchors. The 2 main techniques used are double- and single-row suture anchor stabilization, with debate over superiority. Biomechanical studies have shown improved reduction and stabilization with the double-row over the single-row suture anchor technique; however, this has not been reported for small or comminuted bony fragments. Both techniques have shown promising preliminary clinical outcomes. In this Technical Note, we describe our preferred technique for arthroscopic instability repair using a single-row all-suture anchor method with the incorporation of a comminuted bony Bankart fragment in the lateral decubitus position