IRAS 16293-2422: Evidence for Infall onto a Counter-Rotating Protostellar Accretion Disk

We report high spatial resolution VLA observations of the low-mass star-forming region IRAS 16293-2422 using four molecular probes: ethyl cyanide (CH$_3$CH$_2$CN), methyl formate (CH$_3$OCHO), formic acid (HCOOH), and the ground vibrational state of silicon monoxide (SiO). Ethyl cyanide emiss ion has a spatial scale of $\sim20''$ and encompasses binary cores A and B as determined by continuum emission peaks. Surrounded by formic acid emission, methyl formate emission has a spatial scale of $\sim6''$and is confined to core B. SiO emission shows two velocity components with spatial scales less than 2$''$ that map $\sim2''$ northeast of the A and B symmetry axis. The redshifted SiO is $\sim2''$ northwest of blueshifted SiO along a position angle of $\sim135^o$ which is approximately parallel to the A and B symmetry axis. We interpret the spatial position offset in red and blueshifted SiO emission as due to rotation of a protostellar accretion disk and we derive $\sim$1.4 M$_{\odot}$ interior to the SiO emission. In the same vicinity, Mundy et al. (1986) also concluded rotation of a nearly edge-on disk from OVRO observations of much stronger and ubiquitous $^{13}$CO emission but the direction of rotation is opposite to the SiO emission findings. Taken together, SiO and $^{13}$CO data suggest evidence for a counter-rotating disk. Moreover, archival BIMA array $^{12}$CO data show an inverse P Cygni profile with the strongest absorption in close proximity to the SiO emission, indicating unambiguous material infall toward the counter-rotating protostellar disk at a new source location within the IRAS 16293-2422 complex. The details of these observations and our interpretations are discussed.Comment: 18 pages, 5 figures, accepted for publication in the Astrophysical Journa

HFE and transferrin directly compete for transferrin receptor in solution and at the cell surface

Transferrin receptor (TfR) is a dimeric cell surface protein that binds both the serum iron transport protein transferrin (Fe-Tf) and HFE, the protein mutated in patients with the iron overload disorder hereditary hemochromatosis. HFE and Fe-Tf can bind simultaneously to TfR to form a ternary complex, but HFE binding to TfR lowers the apparent affinity of the Fe-Tf/TfR interaction. This apparent affinity reduction could result from direct competition between HFE and Fe-Tf for their overlapping binding sites on each TfR polypeptide chain, from negative cooperativity, or from a combination of both. To explore the mechanism of the affinity reduction, we constructed a heterodimeric TfR that contains mutations such that one TfR chain binds only HFE and the other binds only Fe-Tf. Binding studies using a heterodimeric form of soluble TfR demonstrate that TfR does not exhibit cooperativity in heterotropic ligand binding, suggesting that some or all of the effects of HFE on iron homeostasis result from competition with Fe-Tf for TfR binding. Experiments using transfected cell lines demonstrate a physiological role for this competition in altering HFE trafficking patterns

The central engines of radio-quiet quasars

Two rival hypotheses have been proposed for the origin of the compact radio flux observed in radio-quiet quasars (RQQs). It has been suggested that the radio emission in these objects, typically some two or three orders of magnitude less powerful than in radio-loud quasars (RLQs), represents either emission from a circumnuclear starburst or is produced by radio jets with bulk kinetic powers 10^3 times lower than those of RLQs with similar luminosity ratios in other wavebands. We describe the results of high resolution (parsec-scale) radio-imaging observations of a sample of 12 RQQs using the Very Long Baseline Array (VLBA). We find strong evidence for jet-producing central engines in 8 members of our sample.Comment: 7 pages, 8 figures. Accepted for publication in MNRA

The influence of acute variable resistance loading on subsequent free-weight maximal squat performance

Elastic bands attached to a loaded barbell during a squat exercise create a variable resistance (VR), thus changing the mechanical loading and stress placed through the musculoskeletal system. Preconditioning the neuromuscular system using near-maximal or maximal voluntary contractions (MVC) can induce a phenomenon known as post-activation potentiation (PAP) to enhance performance to ‘supramaximal’ levels. However, the potentiating effects of VR on subsequent free-weight resistance (FWR) squat performance have not been examined. Thus, the aim of the present study was to examine the influence of VR exercise using elastic bands on subsequent FWR squat performance. Sixteen recreationally active men (age = 26.0 ± 7.8 yr, height = 1.7 ± 0.2 m, mass 82.6 ± 12.7 kg) experienced in squatting (>3yr) volunteered for the study after giving written informed consent; ethical approval was granted from the University of Northampton. Subjects’ 1-RM were determined then on two subsequent days either a 3-RM FWR (control) or a 3-RM VR (experimental) squat exercise was performed at 85% 1-RM (35% of the load generated from band tension in the VR condition). Five minutes later, motion analysis recorded knee joint kinematics during a subsequent FWR 1-RM squat, with vastus medialis, vastus lateralis, rectus femoris and semitendinosus electromyograms (EMG) simultaneously recorded. Paired t-tests were used to determine significance, accepted at p0.05) or EMG amplitude (5.9%; p>0.05) occurred. No subjects increased 1-RM in the FWR condition, however 13 of 16 (81%) increased 1-RM by ~10% following VR. Preconditioning the neuromuscular system using VR significantly increased 1-RM without changes in knee extensor muscle activity or knee flexion angle, however eccentric and concentric velocities were reduced. Thus, VR can potentiate the neuromuscular system to enhance subsequent maximal lifting performance. The lack of change in EMG suggests that changes in muscle activity were small or non-existent, which may be explained by force-velocity effects (slower movement = larger forces). Alternatively a greater activation of hip musculature (not measured in the present study) may allow a greater total lower limb force to be developed. Regardless, as 1-RM increased greater lower-limb loading occurred, thus VR potentiated the neuromuscular system and could enhance training stimuli

Potential shaping and the method of controlled Lagrangians

We extend the method of controlled Lagrangians to include potential shaping for complete state-space stabilization of mechanical systems. The method of controlled Lagrangians deals with mechanical systems with symmetry and provides symmetry-preserving kinetic shaping and feedback-controlled dissipation for state-space stabilization in all but the symmetry variables. Potential shaping complements the kinetic shaping by breaking symmetry and stabilizing the remaining state variables. The approach also extends the method of controlled Lagrangians to include a class of mechanical systems without symmetry such as the inverted pendulum on a cart that travels along an incline

The swine flu alert: keeping Asia safe

After years of concern about H5N1 bird flu, the new flu causing global alarm is a pig virus of the H1N1 family. As influenza reports erupt around the world, inevitable questions are arising. Is this the big one? Are we prepared