Additional file 1: of Does psychological stress in patients with clinically suspect arthralgia associate with subclinical inflammation and progression to inflammatory arthritis?

Supplementary material. (DOCX 195 kb

Additional file 6: of Body mass index and extent of MRI-detected inflammation: opposite effects in rheumatoid arthritis versus other arthritides and asymptomatic persons

is a figure showing the association between BMI (both when presented on a continuous scale or categorized) and ACPA titers in early RA patients. (DOCX 218 kb

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Correlation of anti-CarP antibody and ACPA IgM, IgA, and IgG subclasses and RF-IgM with anti-CarP antibody and ACPA IgM in IgG double-positive RA. ELISAs were performed to detect anti-CarP antibody and ACPA isotypes and IgG subclasses in sera of 114 RA patients. Levels of anti-CarP antibodies and ACPAs were plotted against each other, each IgG subclass and isotype separately (A–F). As internal control anti-CarP IgM and ACPA IgM were plotted against RF-IgM (G, H). Spearman Rank tests were performed to investigate correlations. HC; healthy controls, RA; rheumatoid arthritis, ACPA; anti-citrullinated protein antibodies, anti-CarP antibody; anti-carbamylated protein antibody, RF; rheumatoid factor, AU/ml; arbitrary units per millilitre. (TIF 42723 kb

Camptotheca acuminata Decne.

原著和名: カンレンボク科名: ヌマミズキ科 = Nyssaceae採集地: 愛知県 南設楽郡 鳳来町 愛知県林業試験場 (三河 南設楽郡 鳳来町 愛知県林業試験場)採集日: 1985/8/13採集者: 小林元男整理番号: JH026731国立科学博物館整理番号: TNS-VS-976731備考: 旱蓮

Additional file 4: Figure S3. of MRI-detected osteitis is not associated with the presence or level of ACPA alone, but with the combined presence of ACPA and RF

BME scores of ACPA-positive patients with RA or UA (n = 123) with low, intermediate, or high levels of ACPA. Horizontal lines represent median. Whiskers show the 10th–90th percentile. Dots represent outliers. Baseline ACPA levels are shown categorically as low, intermediate, or high. The groups were as follows: low ≥7 U/ml, intermediate ≥167 U/ml, and high ≥327 U/ml. Low: n = 57; intermediate: n = 27; high: n = 39. ACPA anti-citrullinated protein antibodies, BME bone marrow edema. Kruskal-Wallis test, p = 0.23. (JPG 19 kb

Additional file 2: of An investigation of the added value of an ACPA multiplex assay in an early rheumatoid arthritis setting

Baseline characteristics of anti-CCP-2-negative RA patients. Baseline characteristics of anti-CCP-2-negative RA patients (n = 279) that are multiplex-negative or -positive. CCP cyclic citrullinated peptide, RA rheumatoid arthritis. (PDF 40 kb

Additional file 1: of An investigation of the added value of an ACPA multiplex assay in an early rheumatoid arthritis setting

Diagnosis of anti-CCP-2-negative non-RA patients. Diagnoses of anti-CCP-2-negative non-RA patients (n = 135) as assessed by an experienced rheumatologist after 1 year of follow-up stratified for multiplex positivity. CCP cyclic citrullinated peptide, RA rheumatoid arthritis. (PDF 14 kb

Additional file 2: of PTGER4 gene variant rs76523431 is a candidate risk factor for radiological joint damage in rheumatoid arthritis patients: a genetic study of six cohorts

Table S1. Multivariate linear mixed models to analyze the time-varying effect of the PTGER4 rs6896969 variant in radiographic joint damage of the HCSC-RAC, PEARL, and PAZ cohorts. Table S2. Single-nucleotide polymorphisms with p < 0.05 in the constant effect pooled analysis from the discovery cohorts. Table S3. Single-nucleotide polymorphisms with p < 0.05 in the time-varying effect pooled analysis from the discovery cohorts. Table S4. Single-nucleotide polymorphisms selected for replication in the constant effect analysis and their associations with radiological joint damage in the six cohorts. Table S5. Single-nucleotide polymorphisms selected for replication in the time-varying effect analysis and their associations with radiological joint damage in the six cohorts. (DOC 325 kb

Additional file 1: of PTGER4 gene variant rs76523431 is a candidate risk factor for radiological joint damage in rheumatoid arthritis patients: a genetic study of six cohorts

Figure S1. Region analyzed in the fine-mapping analysis. Figure S2. Linkage disequilibrium blocks among the significant SNPs (pooled p < 0.05) from the constant effect analysis. Figure S3. Linkage disequilibrium blocks among the significant SNPs (pooled p < 0.05) from the time-varying effect analysis. (DOC 845 kb

Additional file 6: Figure S6. of The prevalence of ACPA is lower in rheumatoid arthritis patients with an older age of onset but the composition of the ACPA response appears identical

Showing association between age of onset and onset of symptoms within RA patients of the Leiden EAC. (a) Results of logistic regression analyses of age at RA onset in relation to the onset of symptoms. OR of 1.01 indicates that per 1-year increase in the age of onset, the odds of having (sub)acute onset increase 1%. This reflects 12% (1.0110) per 10-year increase in age of onset and 25% (1.0120) per 20-year increase in age of onset. (b) Proportion of RA patients with (sub)acute onset of symptoms in three age groups (p = 0.003). Number of patients per age group: <40, n = 181; 40–60, n = 466; >60, n = 537. (TIF 2476 kb