Accumulation in East Greenland Fjords and on the Continental Shelves Adjacent to the Denmark Strait over the Last Century Based on 210Pb Geochronology

Sediment (SAR) and mass (MAR) accumulation rates for the last 100 years are derived from 210Pb profiles of box cores collected in three fjords and on the continental shelf in the Kangerlussuaq region, East Greenland, and on the SW Iceland continental shelf. The MAR is lower on East Greenland (0.09 g/cm²·yr) than on SW Iceland (0.14 g/cm²·yr) because of differences in the biogenic component of the sediments, although SAR is similar. The differences in accumulation rates of the three East Greenland fjords are due to their dominant sediment sources and basin areas. Kangerlussuaq Fjord, the largest fjord, is dominated by iceberg sediment input and has a MAR of 0.43 g/cm²·yr at 50 km from the fjord head. Miki Fjord, the smallest fjord, is dominated by glaciofluvial sediment input with a MAR of 0.29 g/cm²·yr of sediment at 10 km from the fjord head. Nansen Fjord is intermediate in size, with an iceberg-dominated sediment supply; MAR is 1.01 g/cm²·yr near the fjord head and 0.17 g/cm²·yr at 20 km from the fjord head. 137Cs is used as a secondary indicator of sediment source, and the high activity level of 137Cs in Miki Fjord indicates glaciofluvial sediment sources. Zones of constant activity in some of the box cores are attributed to either bioturbation in the surface mixed layer or turbidites. We would be hesitant to extend the recent 210Pb-based accumulation rates to estimate the Holocene accumulation rates.On a calculé les taux d'accumulation de sédiments (TAS) et de masse (TAM) pour les cent dernières années à partir des profils du 210Pb dans des carottes rectangulaires prélevées dans trois fjords et sur le plateau continental de la région de Kangerlussuaq (est du Groenland), et sur le plateau continental du sud-ouest de l'Islande. Le TAM est plus faible dans l'est du Groenland (0,09 g/cm² par an) que dans le sud-ouest de l'Islande (0,14 g/cm² par an) en raison des différences dans la composante biogène des sédiments, bien que le TAS soit similaire. La différence entre les taux d'accumulation des trois fjords de l'est du Groenland est due à leurs sources majeures de sédiments et à leurs bassins de réception. Le fjord Kangerlussuaq, le plus grand des trois, est dominé par un apport de sédiments provenant d'icebergs et a un TAM de 0,43 g/cm² par an à 50 km de son extrémité amont. Le fjord Miki, qui est le plus petit, est dominé par un apport de sédiments fluvio-glaciaires avec un TAM de 0,29 g/cm² par an de sédiments à 10 km de son extrémité amont. Le fjord Nansen est de taille moyenne, et l'apport sédimentaire y provient en majorité d'icebergs; le TAM est de 1,01 g/cm² par an près de l'extrémité amont et de 0,17 g/cm² par an à 20 km de l'extrémité amont. Le 137Cs est utilisé comme indicateur secondaire de la source de sédiments, et le niveau d'activité élevé du 137Cs dans le fjord Miki révèle que les sédiments sont d'origine fluvio-glaciaire. Dans certaines des carottes rectangulaires, on attribue les zones d'activité constante soit à une bioturbation dans la couche mixte de surface, soit à des turbidités. Nous hésiterions à recourir aux récents taux d'accumulation fondés sur le 210Pb pour estimer les taux d'accumulation durant l'holocène

An architecture study of a Byzantine-resilient processor using authentication

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1994.Includes bibliographical references (p. 121-123).This architecture study provides the ground work for implementing a new generation of Byzantine resilient processors using authentication. The use of authentication allows a significant reduction in the theoretical requirements necessary for providing Byzantine resilience, or the ability to continue correct operation in the presence of arbitrary or even malicious faults. This decrease in requirements led to a goal of providing a system which combines the stringent standards embodied by Byzantine resilience with the lower costs necessary to make the system viable for more markets than previous Byzantine resilient processors. A layering scheme is proposed which can be placed between the user and hardware. These layers consist of protocols which provide the basic building blocks of the architecture. The proposed authentication protocol which provides the digital signatures used to verify the origin and contents of messages is a public-key protocol using 32-bit Cyclic Redundancy Codes (CRC's) to encode the message with 32-bit modular inverse key pairs to sign and authenticate the CRC. An interactive consistency protocol responsible for correctly distributing single-source data between processors is built using the SM(m) algorithm from [LSP82] with improvements suggested in [Dol83]. A voting protocol responsible for generating a group consensus value guaranteed to be the same on all nonfaulty processors suggests exchanging unsigned messages and then using a full-set majority vote choice() function to calculate the group consensus value. Finally, the proposed synchronization protocol needed to provide synchronized virtual clocks on all nonfaulty processors is placed on top of a full message exchange (FME) known as a From_all exchange to read the clocks on other processors. A time adjustment is then calculated using a technique suggested in [LM84].by Anne L. Clark.M.S

Magnetic Resonance Imaging of Optic Nerve Traction During Adduction in Primary Open-Angle Glaucoma With Normal Intraocular Pressure.

PurposeWe used magnetic resonance imaging (MRI) to ascertain effects of optic nerve (ON) traction in adduction, a phenomenon proposed as neuropathic in primary open-angle glaucoma (POAG).MethodsSeventeen patients with POAG and maximal IOP ≤ 20 mm Hg, and 31 controls underwent MRI in central gaze and 20° to 30° abduction and adduction. Optic nerve and sheath area centroids permitted computation of midorbital lengths versus minimum paths.ResultsAverage mean deviation (±SEM) was -8.2 ± 1.2 dB in the 15 patients with POAG having interpretable perimetry. In central gaze, ON path length in POAG was significantly more redundant (104.5 ± 0.4% of geometric minimum) than in controls (102.9 ± 0.4%, P = 2.96 × 10-4). In both groups the ON became significantly straighter in adduction (28.6 ± 0.8° in POAG, 26.8 ± 1.1° in controls) than central gaze and abduction. In adduction, the ON in POAG straightened to 102.0% ± 0.2% of minimum path length versus 104.5% ± 0.4% in central gaze (P = 5.7 × 10-7), compared with controls who straightened to 101.6% ± 0.1% from 102.9% ± 0.3% in central gaze (P = 8.7 × 10-6); and globes retracted 0.73 ± 0.09 mm in POAG, but only 0.07 ± 0.08 mm in controls (P = 8.8 × 10-7). Both effects were confirmed in age-matched controls, and remained significant after correction for significant effects of age and axial globe length (P = 0.005).ConclusionsAlthough tethering and elongation of ON and sheath are normal in adduction, adduction is associated with abnormally great globe retraction in POAG without elevated IOP. Traction in adduction may cause mechanical overloading of the ON head and peripapillary sclera, thus contributing to or resulting from the optic neuropathy of glaucoma independent of IOP

Willingness of Private Physicians to Be Involved in Smallpox Preparedness and Response Activities

Background. The public health system continues its efforts to prepare for bioterrorist events, such as a smallpox outbreak, but may need to call on other health professionals to ensure sufficient capacity to implement preparedness plans. Objective. The goal was to understand the willingness of primary care physicians to participate in possible smallpox pre- or post-event activities. Methods. A 23-question mail survey was sent to a national random sample of 727 internists and 720 family physicians. After three mailings, a one-page version of the survey was sent to nonrespondents. Results. Response rates were 26% for questions common to both surveys and 22% for questions on the longer survey only. Respondents to the survey expressed moderate support for participating in certain smallpox pre- and post-event activities. Under a pre-event scenario, many providers would be willing to vaccinate first responders in their practice, and roughly one-third would be willing to vaccinate patients in their practice or to work in a public health clinic as a vaccinator. Most physicians, however, would be unwilling to be vaccinated themselves. Under post-event conditions, most providers would be willing to vaccinate their own patients, and many would vaccinate other community members in their practice. Conclusions. Despite the low response rate, information from this study on the smallpox preparedness activities in which physicians are most willing to participate can help to inform efforts by public health officials and private physicians to collaborate on bioterrorism preparedness efforts.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/63165/1/bsp.2005.3.16.pd

Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells

© The Author(s) 2018Limited access to human islets has prompted the development of human beta cell models. The human beta cell lines EndoC-βH1 and EndoC-βH2 are increasingly used by the research community. However, little is known of their electrophysiological and secretory properties. Here, we monitored parameters that constitute the glucose-triggering pathway of insulin release. Both cell lines respond to glucose (6 and 20 mM) with 2- to 3-fold stimulation of insulin secretion which correlated with an elevation of [Ca2+]i, membrane depolarisation and increased action potential firing. Similar to human primary beta cells, KATP channel activity is low at 1 mM glucose and is further reduced upon increasing glucose concentration; an effect that was mimicked by the KATP channel blocker tolbutamide. The upstroke of the action potentials reflects the activation of Ca2+ channels with some small contribution of TTX-sensitive Na+ channels. The repolarisation involves activation of voltage-gated Kv2.2 channels and large-conductance Ca2+-activated K+ channels. Exocytosis presented a similar kinetics to human primary beta cells. The ultrastructure of these cells shows insulin vesicles composed of an electron-dense core surrounded by a thin clear halo. We conclude that the EndoC-βH1 and -βH2 cells share many features of primary human β-cells and thus represent a useful experimental model.Peer reviewedFinal Published versio

Congenital myasthenic syndrome in Golden Retrievers is associated with a novel COLQ mutation.

BackgroundCongenital myasthenic syndromes (CMSs) are a group of inherited disorders of neuromuscular transmission that may be presynaptic, synaptic, or postsynaptic. Causative mutations have been identified in 4 breeds including the Labrador Retriever, Jack Russell Terrier, Heideterrier, and Danish Pointing Dog.Hypothesis/objectiveClinical and genetic characterization of a neuromuscular disorder in Golden Retriever (GR) puppies.AnimalsFour GR puppies from California were evaluated for generalized muscle weakness beginning at weaning. Biological specimens were collected from the affected puppies, and familial information was obtained. Blood or buccal swabs were obtained from 63 unaffected GRs.MethodsComplete physical, neurological, electrodiagnostic, and histological evaluations and biochemical quantification of muscle acetylcholine receptors were performed. Polymerase chain reaction was used to amplify the 17 exons of COLQ, and sequences were obtained by Sanger sequencing. Variant frequency was assessed in unrelated GRs and a public database.ResultsClinical, neurological, and electrodiagnostic evaluations confirmed a disorder of neuromuscular transmission in a GR family. Sequencing of all exons and splice sites of a primary candidate gene, COLQ, identified a point mutation that predicts an amino acid substitution (G294R). The primary COLQ transcript was absent from affected muscle samples. All affected puppies were homozygous for the mutation, which was not detected outside this GR family or in other breeds.Conclusions and clinical importanceWe confirmed the diagnosis of a CMS in GR puppies and identified a novel COLQ mutation. The COLQ gene encodes the collagenous tail of acetylcholinesterase, the enzyme responsible for termination of skeletal muscle contraction by clearing acetylcholine at the neuromuscular junction. Clinicians and breeders should be aware of this CMS in GR puppies with an early onset of weakness