Alien Registration- Nielsen, Anne K. (Pittston, Kennebec County)

https://digitalmaine.com/alien_docs/16772/thumbnail.jp

Quantum state engineering, purification, and number resolved photon detection with high finesse optical cavities

We propose and analyze a multi-functional setup consisting of high finesse optical cavities, beam splitters, and phase shifters. The basic scheme projects arbitrary photonic two-mode input states onto the subspace spanned by the product of Fock states |n>|n> with n=0,1,2,.... This protocol does not only provide the possibility to conditionally generate highly entangled photon number states as resource for quantum information protocols but also allows one to test and hence purify this type of quantum states in a communication scenario, which is of great practical importance. The scheme is especially attractive as a generalization to many modes allows for distribution and purification of entanglement in networks. In an alternative working mode, the setup allows of quantum non demolition number resolved photodetection in the optical domain.Comment: 14 pages, 10 figure

Truncation of lattice fractional quantum Hall Hamiltonians derived from conformal field theory

Conformal field theory has recently been applied to derive few-body Hamiltonians whose ground states are lattice versions of fractional quantum Hall states. The exact lattice models involve interactions over long distances, which is difficult to realize in experiments. It seems, however, that such long-range interactions should not be necessary, as the correlations decay exponentially in the bulk. This poses the question, whether the Hamiltonians can be truncated to contain only local interactions without changing the physics of the ground state. Previous studies have in a couple of cases with particularly much symmetry obtained such local Hamiltonians by keeping only a few local terms and numerically optimizing the coefficients. Here, we investigate a different strategy to construct truncated Hamiltonians, which does not rely on optimization, and which can be applied independent of the choice of lattice. We test the approach on two models with bosonic Laughlin-like ground states with filling factor $1/2$ and $1/4$, respectively. We first investigate how the coupling strengths in the exact Hamiltonians depend on distance, and then we study the truncated models. For the case of $1/2$ filling, we find that the truncated model with truncation radius $\sqrt{2}$ lattice constants on the square lattice and $1$ lattice constant on the triangular lattice has an approximate twofold ground state degeneracy on the torus, and the overlap per site between these states and the states constructed from conformal field theory is higher than $0.99$ for the lattices considered. For the model at $1/4$ filling, our results give some hints that a truncation radius of $\sqrt{5}$ on the square lattice and $\sqrt{7}$ on the triangular lattice might be enough, but the finite size effects are too large to judge whether the topology is, indeed, present in the thermodynamic limit.Comment: 8 Pages, 10 Figure

Blocking of carnitine palmitoyl transferase 1 potently reduces stress-induced depression in rat highlighting a pivotal role of lipid metabolism

AbstractMajor depressive disorder is a complex and common mental disease, for which the pathology has not been elucidated. The purpose of this study is to provide knowledge about the importance of mitochondrial dysfunction, dysregulated lipid metabolism and inflammation. Mitochondrial carnitine palmitoyl transferase 1a (CPT1a) is a key molecule involved in lipid metabolism and mutations in CPT1a causing reduced function is hypothesized to have a protective role in the development of depression. Moreover, CPT1a is found to be upregulated in suicide patients with history of depression. Therefore, we hypothesized that inhibition of CPT1a activity can be developed as an innovative treatment strategy for depression. Stress exposure combined with different pharmacological treatment regimens; Etomoxir, CPT1 blocker, and Escitalopram, a favoured antidepressant drug, was applied in state-of-the-art chronic mild stress model. Etomoxir treatment induced statistical significant reduction of anhedonic behavior compared to vehicle treatment (p &lt; 0.0001) and reversed depression-like phenotype in 90% of the rats (p = 0.0007), whereas Escitalopram only proved 57% efficacy. Moreover, Etomoxir revealed downregulation of interferon-γ, interleukin-17α and tumor necrosis factor-α. This indicate that alteration in metabolism is pivotal in the pathogenesis of depression, since CPT1 blockage is highly efficient in treating anhedonia and inflammation, thereby opening up for a novel class of antidepressant medication.</jats:p