2,606 research outputs found
THE CHANGING FACE OF PSYCHOLOGY: CAREER AND LEADERSHIP ASPIRATIONS OF FEMALE DOCTORAL STUDENTS IN COUNSELING AND CLINICAL PSYCHOLOGY
This study aimed to advance understanding of career-related experiences of female graduate students in counseling and clinical doctoral programs. Specifically, the study investigated achievement motivation, career role salience, consideration for future family and partner, and social support as predictors of leadership and career aspirations. Two hundred and two female graduate students in either counseling or clinical Ph.D. programs were sampled. Results indicated that achievement motivation, specifically the desire to work hard, was the most important predictor of career and leadership aspirations, and was the only consistent predictor across different types of aspirations. Additionally, work role salience contributed to the prediction of career-related aspirations. Last, differences emerged among women who were in the early years of their graduate program versus those in the later years of doctoral study. These findings could contribute to the literature on womens career decision making and have implications for practice and research
Engineering of flavin-binding proteins for superresolution and bioluminescence microscopy
[no abstract
What is public relations to society? Toward an economically informed understanding of public relations
The notion of public relations contributing to the fabric of society is heavily contested in
the public sphere and under-researched by the academy. The authors of this paper propose
that the study of the relevance of public relations to society can be enlightened by
turning to economics. Using information asymmetry as a framework, the argument is that
public relations can be analyzed as a social institution that both helps to mitigate market
imperfections and consequently increases the efficiency with which societyâs resources
are allocated as well as the chances for more market participants to derive value out of
economic transaction
What is public relations to society? Toward an economically informed understanding of public relations
The notion of public relations contributing to the fabric of society is heavily contested in
the public sphere and under-researched by the academy. The authors of this paper propose
that the study of the relevance of public relations to society can be enlightened by
turning to economics. Using information asymmetry as a framework, the argument is that
public relations can be analyzed as a social institution that both helps to mitigate market
imperfections and consequently increases the efficiency with which societyâs resources
are allocated as well as the chances for more market participants to derive value out of
economic transaction
De novo missense variants in FBXO11 alter its protein expression and subcellular localization
Recently, others and we identified de novo FBXO11 (F-Box only protein 11) variants as causative for a variable neurodevelopmental disorder (NDD). We now assembled clinical and mutational information on 23 additional individuals. The phenotypic spectrum remains highly variable, with developmental delay and/or intellectual disability as the core feature and behavioral anomalies, hypotonia and various facial dysmorphism as frequent aspects. The mutational spectrum includes intragenic deletions, likely gene disrupting and missense variants distributed across the protein. To further characterize the functional consequences of FBXO11 missense variants, we analyzed their effects on protein expression and localization by overexpression of 17 different mutant constructs in HEK293 and HeLa cells. We found that the majority of missense variants resulted in subcellular mislocalization and/or reduced FBXO11 protein expression levels. For instance, variants located in the nuclear localization signal and the N-terminal F-Box domain lead to altered subcellular localization with exclusion from the nucleus or the formation of cytoplasmic aggregates and to reduced protein levels in western blot. In contrast, variants localized in the C-terminal Zn-finger UBR domain lead to an accumulation in the cytoplasm without alteration of protein levels. Together with the mutational data, our functional results suggest that most missense variants likely lead to a loss of the original FBXO11 function and thereby highlight haploinsufficiency as the most likely disease mechanism for FBXO11-associated NDDs
Kinetics of Palladium(0)âAllyl Interactions in the TsujiâTrost Reaction, derived from SingleâMolecule Fluorescence Microscopy
Singleâmolecule (SM) chemistry is devoted to unravel reaction steps which are hidden in cuvette experiments. Controversies about the substrate activation during the TsujiâTrost deallylation motivated us to study, on the singleâmolecule level, the kinetics of the catalyst precursor Pd(PPh3)4 with our recently designed twoâcolor fluorescent probes. Photochemical, metalâfree bypass reactions were found and taken into account by the combination of spectrally separated singleâmolecule TIRFâmicroscopy and stateâofâthe art analysis procedures. Unselective Ïâcomplex formation (KDâ103â
Mâ1) precedes the insertion of the active catalyst into the CâOR bond (ROâ=leaving group), indicated by the lacking immediate change of fluorescence color. The formed intermediate then decomposes on a time scale ofâ„2 â 3â
s to the deallylated product
Progress Report on pH-Influenced Photocatalysis for Active Motion
Living systems use catalysis to achieve chemical transformations to comply with their
needs in terms of energy and building blocks. The pH is a powerful means to regulate such processes,
which also influences synthetic systems. In fact, the pH sensitivity of artificial photocatalysts, such
as bismuth vanadate, bears the strong potential of flexibly influencing both the motion pattern and
the speed of catalytic microswimmers, but it has rarely been investigated to date. In this work, we
first present a comprehensive view of the motion behavior of differently shaped bismuth vanadate
microswimmers, discuss influences, such as shape, pH, and conductivity of the solutions, and find
that the motion pattern of the swimmers switches between upright and horizontal at their point of
zero charge. We then apply an immobilizable hydroxypyrene derivative to our substrates to locally
influence the pH of the solution by excited-state proton transfer. We find that the motion pattern
of our swimmers is strongly influenced by this functionalization and a third motion mode, called
tumbling, is introduced. Taking other effects, such as an increased surface roughness of the modified
substrates, into account, we critically discuss possible future developments
Understanding public relations in the âsharing economyâ
In spite of the macro-economic impact of the so-called âsharing economyâ there is a nearly complete dearth of contributions from the communication academy to its discourse. More attention is overdue, particularly for the conceptual pressure the âsharing economyâ is exerting on the public relations function. The authors propose a reconceptualization of public relations by identifying the constitutive aspects of the sharing economy and bringing together the explanatory concepts âcircuits of commerceâ and âviable matchesâ from economic sociology and communicative constitution of organizations theory to develop the notions of âdeliberate disintermediationâ and âcircuits of communicationâ in public relations. The contention is that by doing this, communicative acts not only contribute meaning in the sharing economy, but have economic value. Furthermore, the sharing economy poses challenges to the traditional forms of organizing public relations functions, but offers opportunities to realize different potential when public relations facilitates circuits of communication and becomes a meta-communicative competence embedded within the organization
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