Lifetime affective symptoms and mortality in the MRC National Survey of Health and Development

This thesis investigated associations between lifetime affective symptoms and mortality in the MRC National Survey of Health and Development (NSHD; the British 1946 birth cohort). Affective symptoms were initially rated by teachers when study members were aged 13 and 15; then by semi-structured clinical interview at age 36 using the Present State Examination (PSE); the interview-based Psychiatric Frequency Questionnaire at age 43; and the self-report 28-item General Health Questionnaire at age 53. Mortality data including cause of death was obtained from the NHS Central Register. Follow-up time was from ages of exposure to end of October 2014 (age 68). A wide range of covariates were tested, including sex; early life factors; adult health indicators and health behaviours; psychotropic medication; stressful life events, and social factors. Cox regression showed that after adjustment for sex, severe affective symptoms were associated with an increased risk of mortality compared to those with no or mild symptoms across most ages. There was evidence of an accumulation effect where the risk of mortality increased as affective caseness increased. Adolescent-only, intermittent and chronic caseness were associated with increased risk of mortality compared to those who were never a case. There was a slightly stronger association between affective caseness and cardiovascular mortality compared to cancer mortality; however the strongest associations appeared to be with respect to deaths from ‘other’ causes. After full adjustment, those who were a case at a single point in time and those with adolescent-only caseness had a 46% and 73% increased risk of mortality respectively, compared to those who were never a case. All other associations were largely explained by the covariates, with most relationships attenuated predominantly by self-reported health conditions, physical activity, lung function, smoking, and psychotropic medication use. These results demonstrate the inherent interplay between affective symptoms and physical health, and highlight the importance of early intervention in order to reduce health inequalities

Strategies Utility Managers Used to Implement Renewable Energy Technologies in the Caribbean

Government officials in the Caribbean are encouraging the production of electricity from renewable energy sources to reduce the impact of high electricity rates to customers due to region\u27s dependency on imported fossil fuel. The purpose of this single-case study was to explore the strategies electric utility managers in the Caribbean used to implement renewable energy technologies. The diffusion of innovation theory served as the conceptual framework for the study. Three managers of an electric utility in the Caribbean, who had created strategies to implement renewable energy technologies, participated in face-to-face semistructured interviews. These managers provided in-depth information on approaches used to implement these technologies. Three themes emerged from the thematic analysis of data that were collected from the semistructured interviews and document reviews: development and integration of renewable energy technologies into utility operations, avoidance of future investments in fossil fuels, and inclusion of key stakeholders in the transition to implementing renewable energy technologies. The implications for social change to the Caribbean region from a successful implementation of the technologies may include employment opportunities through the creation of new industries, eradication of energy poverty, and a healthier and cleaner environment. Also, government officials can save significant foreign exchange by not having to import fossil fuel for electricity generation and use these savings to invest in other sectors that can provide further economic and social growth for the people of the region

Manifestations of hysteria in the work of Berni Searle and Diane Victor

No abstract available.Dissertation (MA)--University of Pretoria, 2008.Visual Artsunrestricte

Perceived Readiness for Hospital Discharge in Adult Medical-Surgical Patients

Purpose: The purpose of the study was to identify predictors and outcomes of adult medical-surgical patients\u27 perceptions of their readiness for hospital discharge. Design: A correlational, prospective, longitudinal design with path analyses was used to explore relationships among transition theory-related variables. Setting: Midwestern tertiary medical center. Sample: 147 adult medical-surgical patients. Methods: Predictor variables included patient characteristics, hospitalization factors, and nursing practices that were measured prior to hospital discharge using a study enrollment form, the Quality of Discharge Teaching Scale, and the Care Coordination Scale. Discharge readiness was measured using the Readiness for Hospital Discharge Scale administered within 4 hours prior to discharge. Outcomes were measured 3 weeks postdischarge with the Post-Discharge Coping Difficulty Scale and self-reported utilization of health services. Findings: Living alone, discharge teaching (amount of content received and nurses\u27 skill in teaching delivery), and care coordination explained 51% of readiness for discharge score variance. Patient age and discharge readiness explained 16% of variance in postdischarge coping difficulty. Greater readiness for discharge was predictive of fewer readmissions. Conclusions: Quality of the delivery of discharge teaching was the strongest predictor of discharge readiness. Study results provided support for Meleis\u27 transitions theory as a useful model for conceptualizing and investigating the discharge transition. Implications for Practice: The study results have implications for the CNS role in patient and staff education, system building for the postdischarge transition, and measurement of clinical care outcomes

Developing the Potential of Observation - Generating Ideas Using Video Data From a Nursery School: a Students as Academic Partners Project

This Students as Academic Partners (SAP) project aimed to explore the potential of a creative approach to reflection. Developing approaches to reflective practice is directly relevant for a wide range of professional occupations including school teachers, early years practitioners, lecturers within HE and also trainees. Individual reflections were produced by project participants based on several very short video clips of children in a nursery school. The reflections include speculative observations, explanations and use of theoretical perspectives linked to broader themes. The analysis was extended through a collaborative reflection on the combined individual reflections. The focus on broader themes within this particular project seeks to contribute to an encompassing discourse related to early years practice

Validating the Grit-S scale among postgraduate students in a South African distance education institution

Grit has been associated with student success in a plethora of higher education (HE) studies. In order to measure and evaluate the predictive validity of grit in student success in a particular context, an appropriate, reliable and valid instrument is required. This paper examines the short grit scale’s (Grit-S) psychometric properties among a sample of 837 postgraduate students enrolled at the University of South Africa (UNISA). This appears to be the first study to explore the psychometric rigour of the scale among postgraduates within a South African distance education (DE) setting. An exploratory factor analysis (EFA) followed by partial confirmatory factor analysis (PCFA) revealed that the same two factors commonly reported in the grit literature could be detected in the items tested (i.e. ‘passion’ and ‘perseverance’ for long-term goals), and in combination explained 57.22% of the variance. Model fit indices for the two-factor solution were satisfactory (NFI = 0.984; TLI = 0.981; CFI = 0.991; RMSEA = 0.038). Further results from the item analysis indicated that both factors (passion and perseverance) were soundly reliable, as was the overall Grit-S scale, yielding Cronbach Alpha values of ≥0.77. Overall, the study provides promising evidence that the Grit-S scale can validly and reliably be used to operationalise grit (and the separate dimensions of perseverance and passion) among postgraduates pursuing their DE studies. Further theoretical and practical implications are discussed

Creative Reflection in Action

This (Students as Academic Partners) project aimed to explore the potential of a creative approach to reflection. Developing approaches to reflective practice is directly relevant for teachers and those who are training to become teachers. Individual reflections were produced by project participants based on several very short video clips of children in a nursery school. These individual reflections were extended into a collaborative reflection highlighting common themes. This broader focus seeks to contribute to an encompassing discourse related to early years practice. The poster aims to show how critical reflection and speculation can develop an understanding of the child, their development and potential barriers to this development. Through observing stills from the video footage, viewers of the poster are challenged to speculate about the child’s body language, what they might be doing or whether the learning environment is suitable to develop and progress their knowledge and understanding further

Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death

Sestrin2 is a member of a family of stress responsive proteins, which controls cell viability via antioxidant activity and regulation of the mammalian target of rapamycin protein kinase (mTOR). Sestrin2 is induced by different stress insults, which diminish ATP production and induce energetic stress in the cells. Glucose is a critical substrate for ATP production utilized via glycolysis and mitochondrial respiration as well as for glycosylation of newly synthesized proteins in the endoplasmic reticulum (ER) and Golgi. Thus, glucose starvation causes both energy deficiency and activation of ER stress followed by the unfolding protein response (UPR). Here, we show that UPR induces Sestrin2 via ATF4 and NRF2 transcription factors and demonstrate that Sestrin2 protects cells from glucose starvation-induced cell death. Sestrin2 inactivation sensitizes cells to necroptotic cell death that is associated with a decline in ATP levels and can be suppressed by Necrostatin 7. We propose that Sestrin2 protects cells from glucose starvation-induced cell death via regulation of mitochondrial homeostasis

Higher education, mature students and employment goals: policies and practices in the UK

This article considers recent policies of Higher Education in the UK, which are aimed at widening participation and meeting the needs of employers. The focus is on the growing population of part-time students, and the implications of policies for this group. The article takes a critical perspective on government policies, using data from a major study of mature part-time students, conducted in two specialist institutions in the UK, a London University college and a distance learning university. Findings from this study throw doubt on the feasibility of determining a priori what kind of study pathway is most conducive for the individual in terms of employment gains and opportunities for upward social mobility. In conclusion, doubts are raised as to whether policies such as those of the present UK government are likely to achieve its aims. Such policies are not unique to the UK, and lessons from this country are relevant to most of the developed world