566 research outputs found
A smooth compactification of spaces of stability conditions: the case of the -quiver
We propose a notion of multi-scale stability conditions with the goal of
providing a smooth compactification of the quotient of the space of
projectivized Bridgeland stability conditions by the group of autoequivalence.
For the case of the 3CY category associated with the -quiver this goal is
achieved by defining a topology and complex structure that relies on a plumbing
construction. We compare this compactification to the multi-scale
compactification of quadratic differentials and briefly indicate why even for
the Kronecker quiver this notion needs refinement to provide a full
compactification.Comment: 42 pages. Any comments welcome
The Fokker-Planck equation for bistable potential in the optimized expansion
The optimized expansion is used to formulate a systematic approximation
scheme to the probability distribution of a stochastic system. The first order
approximation for the one-dimensional system driven by noise in an anharmonic
potential is shown to agree well with the exact solution of the Fokker-Planck
equation. Even for a bistable system the whole period of evolution to
equilibrium is correctly described at various noise intensities.Comment: 12 pages, LATEX, 3 Postscript figures compressed an
Novel Strategy to Expand Super-Charged NK Cells with Significant Potential to Lyse and Differentiate Cancer Stem Cells: Differences in NK Expansion and Function between Healthy and Cancer Patients
How relationship norms shape moral obligation in cancelation behavior
Shuqair, S., Costa Pinto, D., Cruz-Jesus, F., Mattila, A. S., da Fonseca Guerreiro, P., & Kam Fung So, K. (2022). Can customer relationships backfire? : How relationship norms shape moral obligation in cancelation behavior. Journal of Business Research, 151(November), 463-472. https://doi.org/10.1016/j.jbusres.2022.07.008 ---Funding Information: The authors Diego and Frederico gratefully acknowledge financial support from FCT Fundação para a CiĂȘncia e a Tecnologia (Portugal), national funding through research grant Information Management Research Center â MagIC/NOVA IMS (UIDB/04152/2020).While prior research indicates that establishing interpersonal interaction with customers is mostly beneficial, this work reveals that the impact of social ties depends on relationship norms (communal vs. exchange). In three studies, including a real-world field dataset (N = 87,615 customers), the current investigation demonstrates the conditions under which interpersonal relationships can increase or decrease customersâ cancelation behavior. The findings indicate that communal (vs. exchange) relationships can increase customersâ future cancelation behaviors. The findings also demonstrate that perceived moral obligation underlies interpersonal effects on cancelation behavior. That is, when providers develop communal (vs. exchange) ties, consumers feel that their interaction with the providers is in a closed social context, which tends to reduce their obligations towards attending their booking, thus increasing cancelation behavior. Theoretical and practical implications for business researchers and practitioners are discussed.publishersversionpublishe
Trust as a mediator in the relationship between childhood sexual abuse and IL-6 level in adulthood
Childhood sexual abuse (CSA) has been shown to predict the coupling of depression and inflammation in adulthood. Trust within intimate relationships, a core element in marital relations, has been shown to predict positive physical and mental health outcomes, but the mediating role of trust in partners in the association between CSA and inflammation in adulthood requires further study. The present study aimed to examine the impact of CSA on inflammatory biomarkers (IL-6 and IL-1ÎČ) in adults with depression and the mediating role of trust. A cross-sectional survey data set of adults presenting with mood and sleep disturbance was used in the analysis. CSA demonstrated a significant negative correlation with IL-6 level (r = -0.28, p<0. 01) in adults with clinically significant depression, while trust showed a significant positive correlation with IL-6 level (r = 0.36, p < .01). Sobel test and bootstrapping revealed a significant mediating role for trust between CSA and IL-6 level. CSA and trust in partners were revealed to have significant associations with IL-6 level in adulthood. Counterintuitively, the directions of association were not those expected. Trust played a mediating role between CSA and adulthood levels of IL-6. Plausible explanations for these counterintuitive findings are discussed
CK1Δ Is Required for Breast Cancers Dependent on ÎČ-Catenin Activity
Background: Aberrant -catenin signaling plays a key role in several cancer types, notably colon, liver and breast cancer. However approaches to modulate -catenin activity for therapeutic purposes have proven elusive to date. Methodology: To uncover genetic dependencies in breast cancer cells that harbor active -catenin signaling, we performed RNAi-based loss-of-function screens in breast cancer cell lines in which we had characterized -catenin activity. Here we identify CSNK1E, the gene encoding casein kinase 1 epsilon (CK1) as required specifically for the proliferation of breast cancer cells with activated -catenin and confirm its role as a positive regulator of -catenin-driven transcription. Furthermore, we demonstrate that breast cancer cells that harbor activated -catenin activity exhibit enhanced sensitivity to pharmacological blockade of Wnt/-catenin signaling. We also find that expression of CK1 is able to promote oncogenic transformation of human cells in a -catenin-dependent manner. Conclusions/Significance: These studies identify CK1 as a critical contributor to activated -catenin signaling in cancer and suggest it may provide a potential therapeutic target for cancers that harbor active -catenin. More generally, these observations delineate an approach that can be used to identify druggable synthetic lethal interactions with signaling pathways that are frequently activated in cancer but are difficult to target with the currently available small molecule inhibitors
Synthetic Lethal Interaction between Oncogenic KRAS Dependency and STK33 Suppression in Human Cancer Cells
An alternative to therapeutic targeting of oncogenes is to perform âsynthetic lethalityâ screens for genes that are essential only in the context of specific cancer-causing mutations. We used high-throughput RNA interference (RNAi) to identify synthetic lethal interactions in cancer cells harboring mutant KRAS, the most commonly mutated human oncogene. We find that cells that are dependent on mutant KRAS exhibit sensitivity to suppression of the serine/threonine kinase STK33 irrespective of tissue origin, whereas STK33 is not required by KRAS-independent cells. STK33 promotes cancer cell viability in a kinase activity-dependent manner by regulating the suppression of mitochondrial apoptosis mediated through S6K1-induced inactivation of the death agonist BAD selectively in mutant KRAS-dependent cells. These observations identify STK33 as a target for treatment of mutant KRAS-driven cancers and demonstrate the potential of RNAi screens for discovering functional dependencies created by oncogenic mutations that may enable therapeutic intervention for cancers with âundruggableâ genetic alterations.National Institutes of Health (U.S.) (grant R33 CA128625)National Institutes of Health (U.S.) (grant NIH U54 CA112962)National Institutes of Health (U.S.) (grant P01 CA095616)National Institutes of Health (U.S.) (grant P01 CA66996)Starr Cancer ConsortiumDoris Duke Charitable FoundationMPN Research FoundationDeutsche Forschungsgemeinschaft (grant SCHO 1215/1-1)Deutsche Forschungsgemeinschaft (grant FR 2113/1-1)Brain Science FoundationLeukemia & Lymphoma Society of Americ
Recommended from our members
Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53
The inefficient clearance of dying cells can lead to abnormal immune responses, such as unresolved inflammation and autoimmune conditions. We show that tumor suppressor p53 controls signaling-mediated phagocytosis of apoptotic cells through its target, Death Domain1α (DD1α), which suggests that p53 promotes both the proapoptotic pathway and postapoptotic events. DD1α appears to function as an engulfment ligand or receptor that engages in homophilic intermolecular interaction at intercellular junctions of apoptotic cells and macrophages, unlike other typical scavenger receptors that recognize phosphatidylserine on the surface of dead cells. DD1α-deficient mice showed in vivo defects in clearing dying cells, which led to multiple organ damage indicative of immune dysfunction. p53-induced expression of DD1α thus prevents persistence of cell corpses and ensures efficient generation of precise immune responses
The state of the Martian climate
60°N was +2.0°C, relative to the 1981â2010 average value (Fig. 5.1). This marks a new high for the record. The average annual surface air temperature (SAT) anomaly for 2016 for land stations north of starting in 1900, and is a significant increase over the previous highest value of +1.2°C, which was observed in 2007, 2011, and 2015. Average global annual temperatures also showed record values in 2015 and 2016. Currently, the Arctic is warming at more than twice the rate of lower latitudes
- âŠ