6 research outputs found
Oral squamous cell cancer: early detection and the role of alcohol and smoking
Objective: Oral squamous cell carcinoma has a remarkable incidence worldwide and a fairly onerous prognosis, encouraging further research on factors that might modify disease outcome. Data sources: A web-based search for all types of articles published was initiated using Medline/Pub Med, with the key words such as oral cancer, alcohol consumption, genetic polymorphisms, tobacco smoking and prevention. The search was restricted to articles published in English, with no publication date restriction (last update 2010). Review Methods: In this review article, we approach the factors for a cytologic diagnosis during OSCC development and the markers used in modern diagnostic technologies as well. We also reviewed available studies of the combined effects of alcohol drinking and genetic polymorphisms on alcohol-related cancer risk. Results: The interaction of smoking and alcohol significantly increases the risk for aero-digestive cancers. The interaction between smoking and alcohol consumption seems to be responsible for a significant amount of disease. Conclusion: Published scientific data show promising pathways for the future development of more effective prognosis. There is a clear need for new prognostic indicators, which could be used in diagnostics and, therefore a better selection of the most effective treatment can be achieved
Muscle metastasis from hepatocellular carcinoma
Background: Hepatocellular carcinoma is the most common primary tumor
of the liver. Disease dissemination occurs through hematogenous routes
and frequently involves the lungs, bone, adrenal glands, and pancreas.
The patterns of the extrahepatic manifestations are diverse. Soft
tissue metastasis is extremely rare and mandates systematic
pathological analysis, which may include the use of specific
immunohistochemical staining. We report metastasis from a
hepatocellular carcinoma, as a discrete subcutaneous mass to the right
humerus muscle. Materials and Methods: We detail the approach to
diagnosis and management of an unusual case of a patient with
hepatocellular carcinoma, in whom we found a metastatic lesion as a
subcutaneous mass to the right humerus muscle nine years after right
hepatectomy. Conclusion: This condition poses differential diagnostic
problems in the settings of clinical and pathological investigations.
Metastasis of hepatocellular carcinoma should be included in the
differential diagnosis of rapidly growing lesions
Muscle metastasis from hepatocellular carcinoma
Background: Hepatocellular carcinoma is the most common primary tumor
of the liver. Disease dissemination occurs through hematogenous routes
and frequently involves the lungs, bone, adrenal glands, and pancreas.
The patterns of the extrahepatic manifestations are diverse. Soft
tissue metastasis is extremely rare and mandates systematic
pathological analysis, which may include the use of specific
immunohistochemical staining. We report metastasis from a
hepatocellular carcinoma, as a discrete subcutaneous mass to the right
humerus muscle. Materials and Methods: We detail the approach to
diagnosis and management of an unusual case of a patient with
hepatocellular carcinoma, in whom we found a metastatic lesion as a
subcutaneous mass to the right humerus muscle nine years after right
hepatectomy. Conclusion: This condition poses differential diagnostic
problems in the settings of clinical and pathological investigations.
Metastasis of hepatocellular carcinoma should be included in the
differential diagnosis of rapidly growing lesions