2,859 research outputs found

    A typology of marine and estuarine hazards and risks as vectors of change : a review for vulnerable coasts and their management

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    This paper illustrates a typology of 14 natural and anthropogenic hazards, the evidence for their causes and consequences for society and their role as vectors of change in estuaries, vulnerable coasts and marine areas. It uses hazard as the potential that there will be damage to the natural or human system and so is the product of an event which could occur and the probability of it occurring whereas the degree of risk then relates to the amount of assets, natural or societal, which may be affected. We give long- and short-term and large- and small-scale perspectives showing that the hazards leading to disasters for society will include flooding, erosion and tsunamis. Global examples include the effects of wetland loss and the exacerbation of problems by building on vulnerable coasts. Hence we emphasise the importance of considering hazard and risk on such coasts and consider the tools for assessing and managing the impacts of risk and hazard. These allow policy-makers to determine the consequences for natural and human systems. We separate locally-derived problems from large-scale effects (e.g. climate change, sea-level rise and isostatic rebound); we emphasise that the latter unmanaged exogenic pressures require a response to the consequences rather than the causes whereas within a management area there are endogenic managed pressures in which we address both to causes and consequences. The problems are put into context by assessing hazards and the conflicts between different uses and users and hence the management responses needed. We emphasise that integrated and sustainable management of the hazards and risk requires 10-tenets to be fulfilled

    Women’s Resistance: Patient Pathographies and Medical Authority

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    In recent years, illness narratives have risen in popularity. Women’s medical narratives in particular have gained momentum in the literary world, and they often share commonalities including the inherent theme of medical resistance and an emphasis on the power dynamic between patients and physicians. This thesis will examine two pathographies, Susanna Kaysen’s Girl, Interrupted and Porochista Khakpour’s Sick, in the contexts of gender and disability studies, as well as theories of illness narratives. I examine how each text resists medical authority, and I also closely survey the physician-patient relationships within each text. The themes of gender and disability emerge in both Khakpour’s and Kaysen’s texts, but in other ways the texts approach illness differently. Using documents from her institutionalization in the 1960s, Kaysen humanizes her fellow patients and challenges medical authority using humor. In contrast, Khakpour uses a storytelling mode, emphasizing location and dislocation and the importance of her Iranian immigrant status and drug addiction to her experience of Lyme disease. These pathographies challenge medical authority through personal narrative

    An observational measure of empathy for autism spectrum : a preliminary study of the development and reliability of the client emotional processing scale

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    People with autism spectrum disorder (ASD), can have difficulties in emotion processing, including recognising their own and others’ emotions, leading to problems in emotion regulation and interpersonal relating. This study reports the development and piloting of the Client Emotional Processing Scale-Autism Spectrum (CEPS-AS), a new observer measure of four interrelated aspects of emotional processing: emotion recognition, self- reflection, cognitive empathy, and affective empathy. Results showed good interrater reliability (alpha: .69–.91), while inter-dimension associations were high (r = .66– .82). The measure was able to detect significant differences on the four dimensions across a short-term humanistic– experiential group therapy. The CEPS-AS shows promise as a potential addition to current self-report instruments measuring empathy or emotion processes in individuals with ASD

    An In Vitro Model of Gastric Inflammation and Treatment with Cobalamin

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    Pernicious anaemia (PA) is an autoimmune condition where antibodies target intrinsic factor and parietal cells, reducing the patient’s ability to absorb cobalamin promoting atrophic gastritis. Treatment guidelines are based on excretion data of hydroxocobalamin from healthy individuals obtained 50 years ago. This manuscript describes the use of phorbol 12-myristate 13-acetate (PMA) to stimulate low grade inflammation in an epithelial colorectal cell line to assess the efficacy of methylcobalamin and hydroxocobalamin. Nitric oxide increased significantly in cells exposed to higher doses of PMA (100 ng/ml, 150 ng/ml, and 200 ng/ml) accompanied by a loss of the characteristic cobblestone morphology with no negative effect on cell activity or viability. A significant reduction in nitric oxide production was associated with the addition of 200 pg/ml hydroxocobalamin, alongside a return to the characteristic cobblestone morphology. This study highlights the use of PMA to promote low grade inflammation in human cell lines to model gastric inflammation associated with autoimmunity; furthermore it raises questions regarding the concentration of cobalamin administered clinically to restore cell functionality, feasibly allowing the patient to receive reduced quantity of the vitamin more regularly, providing the patient with levels which are akin to dietary intake

    The detrimental effects of emotional process dysregulation on decision-making in substance dependence

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    Substance dependence is complex and multifactorial, with many distinct pathways involved in both the development and subsequent maintenance of addictive behaviors. Various cognitive mechanisms have been implicated, including impulsivity, compulsivity, and impaired decision-making. These mechanisms are modulated by emotional processes, resulting in increased likelihood of initial drug use, sustained substance dependence, and increased relapse during periods of abstinence. Emotional traits, such as sensation-seeking, are risk factors for substance use, and chronic drug use can result in further emotional dysregulation via effects on reward, motivation, and stress systems. We will explore theories of hyper and hypo sensitivity of the brain reward systems that may underpin motivational abnormalities and anhedonia. Disturbances in these systems contribute to the biasing of emotional processing toward cues related to drug use at the expense of natural rewards, which serves to maintain addictive behavior, via enhanced drug craving. We will additionally focus on the sensitization of the brain stress systems that result in negative affect states that continue into protracted abstinence that is may lead to compulsive drug-taking. We will explore how these emotional dysregulations impact upon decision-making controlled by goal-directed and habitual action selections systems, and, in combination with a failure of prefrontal inhibitory control, mediate maladaptive decision-making observed in substance dependent individuals such that they continue drug use in spite of negative consequences. An understanding of the emotional impacts on cognition in substance dependent individuals may guide the development of more effective therapeutic interventions

    Selby Alcohol Survey 2015

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    Effect of lower sodium intake on health: systematic review and meta-analyses

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    Objective To assess the effect of decreased sodium intake on blood pressure, related cardiovascular diseases, and potential adverse effects such as changes in blood lipids, catecholamine levels, and renal function. Design Systematic review and meta-analysis. Data sources Cochrane Central Register of Controlled Trials, Medline, Embase, WHO International Clinical Trials Registry Platform, the Latin American and Caribbean health science literature database, and the reference lists of previous reviews. Study selection Randomised controlled trials and prospective cohort studies in non-acutely ill adults and children assessing the relations between sodium intake and blood pressure, renal function, blood lipids, and catecholamine levels, and in non-acutely ill adults all cause mortality, cardiovascular disease, stroke, and coronary heart disease. Study appraisal and synthesis Potential studies were screened independently and in duplicate and study characteristics and outcomes extracted. When possible we conducted a meta-analysis to estimate the effect of lower sodium intake using the inverse variance method and a random effects model. We present results as mean differences or risk ratios, with 95% confidence intervals. Results We included 14 cohort studies and five randomised controlled trials reporting all cause mortality, cardiovascular disease, stroke, or coronary heart disease; and 37 randomised controlled trials measuring blood pressure, renal function, blood lipids, and catecholamine levels in adults. Nine controlled trials and one cohort study in children reporting on blood pressure were also included. In adults a reduction in sodium intake significantly reduced resting systolic blood pressure by 3.39 mm Hg (95% confidence interval 2.46 to 4.31) and resting diastolic blood pressure by 1.54 mm Hg (0.98 to 2.11). When sodium intake was 0.05). There were insufficient randomised controlled trials to assess the effects of reduced sodium intake on mortality and morbidity. The associations in cohort studies between sodium intake and all cause mortality, incident fatal and non-fatal cardiovascular disease, and coronary heart disease were non-significant (P>0.05). Increased sodium intake was associated with an increased risk of stroke (risk ratio 1.24, 95% confidence interval 1.08 to 1.43), stroke mortality (1.63, 1.27 to 2.10), and coronary heart disease mortality (1.32, 1.13 to 1.53). In children, a reduction in sodium intake significantly reduced systolic blood pressure by 0.84 mm Hg (0.25 to 1.43) and diastolic blood pressure by 0.87 mm Hg (0.14 to 1.60). Conclusions High quality evidence in non-acutely ill adults shows that reduced sodium intake reduces blood pressure and has no adverse effect on blood lipids, catecholamine levels, or renal function, and moderate quality evidence in children shows that a reduction in sodium intake reduces blood pressure. Lower sodium intake is also associated with a reduced risk of stroke and fatal coronary heart disease in adults. The totality of evidence suggests that most people will likely benefit from reducing sodium intake

    The role of stripe orientation in target capture success.

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    INTRODUCTION: 'Motion dazzle' refers to the hypothesis that high contrast patterns such as stripes and zigzags may have evolved in a wide range of animals as they make it difficult to judge the trajectory of an animal in motion. Despite recent research into this idea, it is still unclear to what extent stripes interfere with motion judgement and if effects are seen, what visual processes might underlie them. We use human participants performing a touch screen task in which they attempt to 'catch' moving targets in order to determine whether stripe orientation affects capture success, as previous research has suggested that different stripe orientations may be processed differently by the visual system. We also ask whether increasing the number of targets presented in a trial can affect capture success, as previous research has suggested that motion dazzle effects may be larger in groups. RESULTS: When single targets were presented sequentially within each trial, we find that perpendicular and oblique striped targets are captured at a similar rate to uniform grey targets, but parallel striped targets are significantly easier to capture. However, when multiple targets are present simultaneously during a trial we find that striped targets are captured in fewer attempts and more quickly than grey targets. CONCLUSIONS: Our results suggest that there may be differences in capture success based on target pattern orientation, perhaps suggesting that different visual mechanisms are involved in processing of parallel stripes compared to perpendicular/oblique stripes. However, these results do not seem to generalise to trials with multiple targets, and contrary to previous predictions, striped targets appear to be easier to capture when multiple targets are present compared to being presented individually. These results suggest that the different orientations of stripes seen on animals in nature (such as in fish and snakes) may serve different purposes, and that it is unclear whether motion dazzle effects may have greater benefits for animals living in groups.We thank the subjects who volunteered to take part in these experiments.AEH was supported by a BBSRC CASE studentship and MS was supported by a Biotechnology and Biological Sciences Research Council (BBSRC) David Phillips Research Fellowship (BB/G022887/1).This is the final version of the article. It first appeared from BioMed Central via http://dx.doi.org/10.1186/s12983-015-0110-

    Editorial: Bridging the gap between policy and science in assessing the health status of marine ecosystems

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    Human activities,both established and emerging, increasingly affect the provision of marine ecosystem services that deliver societal and economic benefits. Monitoring the status of marine ecosystems and determining how human activities change their capacity to sustain benefits for society requires an evidence-based Integrated Ecosystem Assessment approach that incorporates knowledge of ecosystem functioning and services).Although,there are diverse methods to assess the status of individual ecosystem components, none assesses the health of marine ecosystems holistically, integrating information from multiple ecosystem components. Similarly,while acknowledging the availability of several methods to measure single pressures and assess their impacts, evaluation of cumulative effects of multiple pressures remains scarce.Therefore,an integrative assessment requires us to first understand the response of marine ecosystems to human activities and their pressures and then develop innovative, cost-effective monitoring tools that enable collection of data to assess the health status of large marine areas. Conceptually, combining this knowledge of effective monitoring methods with cost-benefit analyses will help identify appropriate management measures to improve environmental status economically and efficiently. The European project DEVOTES (DEVelopment Of innovative Tools for understanding marine biodiversity and assessing good Environmental Status) specifically addressed these topics in order to support policymakers and managers in implementing the European Marine Strategy Framework Directive. Here, we synthesize our main innovative findings, placing these within the context of recent wider research, and identifying gaps and the major future challenges
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