From paper to electronic

pp. 53-5

Assessment of Antimicrobial Pharmacokinetics Curricula Across Schools and Colleges of Pharmacy in the United States

Introduction Advances in technology and understanding of pharmacokinetic/pharmacodynamic relationships have prompted guideline updates and advances in precision dosing, but the role of clinical pharmacokinetics (PK) in pharmacy education remains inconsistent. Previous surveys of pharmacy school PK curricula revealed large variations in content, integration, and teaching tools but did not focus on antimicrobials or details of andragogy used. Objective Identify how antimicrobial PK is taught in pharmacy curricula across the United States, as well as instructor perceptions of current practices. Methods An online survey was distributed to 118 pharmacy programs across the United States in 2018. This 30-minute questionnaire covered curriculum content, teaching strategies, assessment modalities, and perceptions. Results Completed surveys were received from 53 programs (45% response rate) via relevant course coordinators. Among 35 traditional progressive curriculum programs (TPC), antimicrobial PK was taught in basic science (33, 94%), clinical PK (15, 43%), pharmacology (8, 23%), therapeutics (28, 80%), and skills lab courses (21, 65%). Among 18 integrated block curriculum programs (IBC), it was taught in foundations/principles (17, 94%), organ systems (12, 67%), and skills lab courses (9, 50%). On average, TPC programs had more courses with antimicrobial PK than IBC programs. Vancomycin and aminoglycosides were the most common antimicrobials taught (100%), while didactic lecturing was the predominant andragogy. Multiple choice was the primary assessment modality, being frequently used in 64% of TPC and 68% of IBC courses, respectively. Among respondents, 72% believed more time was needed to teach PK and 53% believed students were adequately prepared at the start of APPEs. Conclusion Antimicrobial PK instruction remains highly inconsistent in U.S. pharmacy schools and colleges. IBC programs may provide less opportunity for antimicrobial PK instruction, which conflicts with the desire for more instruction time. As clinical applications of antimicrobial PK change and expand, it is crucial that pharmacy education prioritizes PK education appropriately

Recommended Revisions to the National SEP‐1 Sepsis Quality Measure: A commentary by the Society of Infectious Diseases Pharmacists on the Infectious Diseases Society of America Position Paper

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154912/1/phar2384.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154912/2/phar2384_am.pd

The Grizzly, November 2, 1999

Is Safety an Issue on Campus? • Payne Stewart, Golfer, Dies in Plane Crash • A First for National French Week • Summer Business Internship Opportunities • Hobson Hall: Home Sweet Home • Opinion: The Effectiveness of College in the Preparation of Students for the World; Gun Control has to be Enacted for Everyone\u27s Safety: A Response; Paying Back the US Dues to the UN • Always Unique, Ben Folds Five Rocks Philadelphia as Part of 1999 Tour • Vecchio, Duncan Power Bears Offense as Bears Rout Mules • Soccer Splits Pair with Fords, Green Terror • Flag Football: APO Downs 2-Time Champion Delta Pi in Double-OT • Junior Vecchio Awarded CC Offensive Football Player of the Week • Tough End to Tough Hockey Season • Volleyball Finishes Best Season Ever • Bears Defense Roars to Big Winhttps://digitalcommons.ursinus.edu/grizzlynews/1450/thumbnail.jp

The Grizzly, October 19, 1999

Homecoming 1999 Hit Ursinus This Past Weekend • Handicap Accessibility On Ursinus College Campus • Adding to the Arts Program? • Reimert: A Suite Housing Experience • Baked to Perfection at Brew Moon • Opinion: Don\u27t They Have Anything Better to do?; Letters to the Editors; Guns Don\u27t Kill People, People Kill People • Modernized Version of Antigone High in Energy, Mediocre in Quality • Bears Fight off Gettysburg Bullets Gridiron • Hockey Battles with Holy Cross and Davis & Elkins; A Close Call and a Win • Two Near Misses for Men\u27s Soccer • Bishop Takes Top Honors at Moravianhttps://digitalcommons.ursinus.edu/grizzlynews/1449/thumbnail.jp

LPS Regulates SOCS2 Transcription in a Type I Interferon Dependent Autocrine-Paracrine Loop

Recent studies suggest that SOCS2 is involved in the regulation of TLR signaling. In this study, we found that the expression of SOCS2 is regulated in human monocyte-derived DC by ligands stimulating TLR2, 3, 4, 5, 8 and 9 signaling. SOCS2 induction by LPS was dependent on the type I IFN regulated transcription factors IRF1 and IRF3 as shown by using silencing RNAs for IRFs. Blocking endogenous type I IFN signaling, by neutralizing antibodies to the receptor IFNAR2, abolished SOCS2 mRNA expression after TLR4 stimulation. Transcription factors STAT3, 5 and 6 displayed putative binding sites in the promoter regions of the human SOCS2 gene. Subsequent silencing experiments further supported that STAT3 and STAT5 are involved in LPS induced SOCS2 regulation. In mice we show that SOCS2 mRNA induction is 45% lower in bone marrow derived macrophages derived from MyD88−/− mice, and do not increase in BMMs from IRF3−/− mice after BCG infection. In conclusion, our results suggest that TLR4 signaling indirectly increases SOCS2 in late phase mainly via the production of endogenous type I IFN, and that subsequent IFN receptor signaling activates SOCS2 via STAT3 and STAT5

I've been converted: Cinderella goes to the ball.

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