Importance of site of infection and antibiotic selection in the treatment of carbapenem-resistant Pseudomonas aeruginosa sepsis

ABSTRACT In a retrospective analysis of 215 patients with carbapenem-resistant Pseudomonas aeruginosa sepsis, we observed a significantly higher risk of mortality associated with respiratory tract infection (risk ratio [RR], 1.20; 95% confidence interval [CI], 1.04 to 1.39; P = 0.010) and lower risk with urinary tract infection (RR, 0.80; 95% CI, 0.71 to 0.90; P = 0.004). Aminoglycoside monotherapy was associated with increased mortality, even after adjusting for confounders (adjusted RR, 1.72; 95% CI, 1.03 to 2.85; P = 0.037), consistent across multiple sites of infection. </jats:p

Effects of traumatic brain injury on cognitive functioning and cerebral metabolites in HIV-infected individuals.

We explored the possible augmenting effect of traumatic brain injury (TBI) history on HIV (human immunodeficiency virus) associated neurocognitive complications. HIV-infected participants with self-reported history of definite TBI were compared to HIV patients without TBI history. Groups were equated for relevant demographic and HIV-associated characteristics. The TBI group evidenced significantly greater deficits in executive functioning and working memory. N-acetylaspartate, a putative marker of neuronal integrity, was significantly lower in the frontal gray matter and basal ganglia brain regions of the TBI group. Together, these results suggest an additional brain impact of TBI over that from HIV alone. One clinical implication is that HIV patients with TBI history may need to be monitored more closely for increased risk of HIV-associated neurocognitive disorder signs or symptoms

Generational Differences in Faculty and Student Comfort with Technology Use

Background: Navigating through online education courses continues to be a struggle for some nursing students. At the same time, integrating technology into online courses can be difficult for nursing faculty. Purpose: The purpose of this study was to assess faculty technology integration practices, student attitudes about technology use, and generational differences related to faculty and student technology use. Methods: A descriptive cross-sectional survey design was used to obtain data for this study. Results: Integration of technology into online courses and student attitudes about technology use were not significantly different by generation. Faculty and students from the Baby Boomer and Generation X reported less comfort using technology and higher levels of anxiety using technology than did individuals from Generation Y. Conclusion: Significant generational variations were not noted in relation to technology integration into courses and overall student attitudes about technology in this study, but differences were noted in relation to comfort with use of technology and anxiety when using technology. Student learning outcomes and satisfaction with learning may be influenced by the student\u27s comfort using technology and faculty\u27s confidence in integrating and using technology to provide online instruction

Nurses\u27 Alumnae Association Bulletin, June 1965

President\u27s Page Officers and Committee Chairmen Financial Report Hospital and School of Nursing Report Student Activities Annual Report Students Activities Annual Report Student Activities Annual Report Jefferson Expansion Program Psychiatric Unit Progress of the Alumnae Association Nightingale Pledge Resume of Alumnae Meetings Nursing Service Staff Association Scholarship Program Sick and Welfare Social Committee Report Bulletin Membership- WHY JOIN? Private Duty Report Annual Giving Report - 1964 PIT Alumnae Day Notes Building Fund Report - 1965 Vital Statistics IN MEMORIAM Class News Affiliated Institutions Notice

Nurses\u27 Alumnae Association Bulletin, June 1964

President\u27s Message Officers and Committee Chairmen Financial Report Hospital and School of Nursing Report Student Activities Jefferson Expansion Program Resume of Alumnae Meetings Staff Nurses Private Duty Social Committee Reports Program Scholarship Bulletin Committee Report Annual Luncheon Notes Membership and Dues Units in Jefferson Expansion Program Center Annual Giving Drive 1963 Report of Ways and Means Committee Jefferson Building Fund Contributions Annual Giving Contributions 1964 Jefferson Building Fund Report Help the Building Fund Committee! Vital Statistics Class News Notice

Preclinical Testing of Erlotinib in a Transgenic Alveolar Rhabdomyosarcoma Mouse Model

Rhabdomyosarcoma is an aggressive childhood malignancy, accounting for more than 50% of all soft-tissue sarcomas in children. Even with extensive therapy, the survival rate among alveolar rhabdomyosarcoma patients with advanced disease is only 20%. The receptor tyrosine kinase Epidermal Growth Factor Receptor (EGFR) has been found to be expressed and activated in human rhabdomyosarcomas. In this study we have used a genetically engineered mouse model for alveolar rhabdomyosarcoma (ARMS) which faithfully recapitulates the human disease by activating the pathognomic Pax3:Fkhr fusion gene and inactivating p53 in the maturing myoblasts. We have demonstrated that tumors from our mouse model of alveolar rhabdomyosarcoma express EGFR at both the mRNA and protein levels. We then tested the EGFR inhibitor, Erlotinib, for its efficacy in this mouse model of alveolar rhabdomyosarcoma. Surprisingly, Erlotinib had no effect on tumor progression, yet mice treated with Erlotinib showed 10–20% loss of body weight. These results suggest that EGFR might not be an a priori monotherapy target in alveolar rhabdomyosarcoma

The Grizzly, October 5, 1999

Bears Clobber Swarthmore During Family Day Game • Family Day A Success • Admission Rumor Proves False • Sophomore Week Set • 811 Main Street • Forget MTV: Career Services Offering UC Seniors Opportunity to Star in Real World • Opinion: Stereotypes on Campus Affect and Hurt Everyone; Letter to the Editors • Ursinus Football Crushes Swarthmore in Centennial Conference Action, 59-0 • Volleyball wins Allentown Invit. and Family Day Tourney • Monumental Changes in UC Cheerleading • Soccer Splits for 1-1 on the Weekhttps://digitalcommons.ursinus.edu/grizzlynews/1447/thumbnail.jp

The Grizzly, November 9, 1999

Could Ursinus be a Target for Thieves? • Sexual Harassment at Ursinus College • John Street Elected New Mayor of Philadelphia • A Makeover for Ursinus Art on Campus • Egypt Air Flight 990 Disaster • BPS: True Student Living • Grizzly Greeks Rush to Greet New Members • Letter to the Editor: Disrespect of Women on the Ursinus Campus; Ursinus Students Fall Victim to False Sense of Security • Response: Racism • UC Baseball Players Receive Defensive Honors for 1999 Season • Football Stretches Streak to Six, Looks to Dickinson for 7 • Men\u27s Soccer Takes Tough Loss • F&M and Gettysburg in NCAA Tourneyhttps://digitalcommons.ursinus.edu/grizzlynews/1451/thumbnail.jp

The Grizzly, October 12, 1999

Homecoming \u2799: Any Questions? • One America • Ursinus Grads Leave with a Diploma and a Low Financial Debt • Students Celebrate Berman Museum\u27s 10th Anniversary • Old Men\u27s at Heart of Ursinus • Opinion: Lott\u27s Lack of Responsibility is a Major Threat to the Security of the World; The Destruction of Chechnya, NATO\u27s Bloody Legacy • WVOU Offers Promising Shows That Could Even Provide Thought • Jeffrey Gaines Jams Again at UC • Field Hockey Downed in Fairfield • Bears Senior Cornerback Dealt Leg Injury; Looks to Return • UC Tackles Johns Hopkins 20-18 • Volleyball Splits Home Matcheshttps://digitalcommons.ursinus.edu/grizzlynews/1448/thumbnail.jp