From the bottom of the sea to the display case: A study into the long-term preservation of archaeological maritime silk textiles in controlled atmosphere

An exceptional group of silk fragments was unearthed in 2014 from a shipwreck, which sank in the mid-17th century, in the Wadden Sea, The Netherlands. A unique example of 17th-century fashion, it comprises about 300 textile fragments from garments, parts of garments and furnishing fabrics, almost entirely made of silk and embroidered or woven with metal thread. These are in remarkably good condition, which may be related to the archaeological environment, the quality of the silk yarns in the fragments, and the presence of metal threads and other metallic objects from the shipwreck. Surviving archaeological maritime silk textiles are extremely rare, which makes this a distinctive find posing challenges for selecting the most suitable conditions for exhibition and storage. Scientific research was carried out with the aim to evaluate the response of modern and archaeological silks to temperature, relative humidity, light and oxygen, in order to define the most suitable parameters for the long-term storage and exhibition of the collection. Artificially aged samples taken from one of the archaeological fragments were analysed at the visual, structural and molecular level by means of colour measurements, Fourier transform infrared spectroscopy (FTIR) and ultra-high performance liquid chromatography coupled to a fluorescence detector (UHPLC-FLD). The results showed that light exposure, in combination with high temperatures, oxygen and moisture strongly affected the silk's structure and molecular composition. Limiting exposure to light and removing oxygen reduced this effect and increased life expectancy significantly. Therefore, the analytical results obtained were essential to defining a preliminary preservation strategy for the collection: while on display, anoxic conditions slow down degradation of the silk by a factor of 4–5, whereas in a in dark storage, a low RH is the most important factor, with anoxic conditions providing additional reduction of decay

Automated implantable cardiac defibrillator and biventricular thoratec assist device as bridge to transplantation in a patient with sarcoidosis

AbstractJ Thorac Cardiovasc Surg 2001;121:1198-

Biliary tract visualization using near-infrared imaging with indocyanine green during laparoscopic cholecystectomy: results of a systematic review

Contains fulltext : 174508.pdf (publisher's version ) (Open Access)BACKGROUND: Near-infrared imaging with indocyanine green (ICG) has been extensively investigated during laparoscopic cholecystectomy (LC). However, methods vary between studies, especially regarding patient selection, dosage and timing. The aim of this systematic review was to evaluate the potential of the near-infrared imaging technique with ICG to identify biliary structures during LC. METHODS: A comprehensive systematic literature search was performed. Prospective trials examining the use of ICG during LC were included. Primary outcome was biliary tract visualization. Risk of bias was assessed using ROBINS-I. Secondly, a meta-analysis was performed comparing ICG to intraoperative cholangiography (IOC) for identification of biliary structures. GRADE was used to assess the quality of the evidence. RESULTS: Nineteen studies were included. Based upon the pooled data from 13 studies, cystic duct (Lusch et al. in J Endourol 28:261-266, 2014) visualization was 86.5% (95% CI 71.2-96.6%) prior to dissection of Calot's triangle with a 2.5-mg dosage of ICG and 96.5% (95% CI 93.9-98.4%) after dissection. The results were not appreciably different when the dosage was based upon bodyweight. There is moderate quality evidence that the CD is more frequently visualized using ICG than IOC (RR 1.16; 95% CI 1.00-1.35); however, this difference was not statistically significant. CONCLUSION: This systematic review provides equal results for biliary tract visualization with near-infrared imaging with ICG during LC compared to IOC. Near-infrared imaging with ICG has the potential to replace IOC for biliary mapping. However, methods of near-infrared imaging with ICG vary. Future research is necessary for optimization and standardization of the near-infrared ICG technique

Authentic Leadership: A Historical Perspective

The purpose of this paper is to interpret the historical meanings conveyed by Barnard's classic works and use them for theorizing about authenticity of leaders in executive roles. Our analysis employs an interpretative logic for meanings of historical ideas proposed by Bevir. As an outcome of this analysis, we identify the conditions that contribute to the failure, crisis, tragedy, and/or success of leader authenticity. In addition, we discuss practical and research implications of the proposed framework.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline

Intravenous and intramyocardial injection of apoptotic white blood cell suspensions prevents ventricular remodelling by increasing elastin expression in cardiac scar tissue after myocardial infarction

Congestive heart failure developing after acute myocardial infarction (AMI) is a major cause of morbidity and mortality. Clinical trials of cell-based therapy after AMI evidenced only a moderate benefit. We could show previously that suspensions of apoptotic peripheral blood mononuclear cells (PBMC) are able to reduce myocardial damage in a rat model of AMI. Here we experimentally examined the biochemical mechanisms involved in preventing ventricular remodelling and preserving cardiac function after AMI. Cell suspensions of apoptotic cells were injected intravenously or intramyocardially after experimental AMI induced by coronary artery ligation in rats. Administration of cell culture medium or viable PBMC served as controls. Immunohistological analysis was performed to analyse the cellular infiltrate in the ischaemic myocardium. Cardiac function was quantified by echocardiography. Planimetry of the infarcted hearts showed a significant reduction of infarction size and an improvement of post AMI remodelling in rats treated with suspensions of apoptotic PBMC (injected either intravenously or intramoycardially). Moreover, these hearts evidenced enhanced homing of macrophages and cells staining positive for c-kit, FLK-1, IGF-I and FGF-2 as compared to controls. A major finding in this study further was that the ratio of elastic and collagenous fibres within the scar tissue was altered in a favourable fashion in rats injected with apoptotic cells. Intravenous or intramyocardial injection of apoptotic cell suspensions results in attenuation of myocardial remodelling after experimental AMI, preserves left ventricular function, increases homing of regenerative cells and alters the composition of cardiac scar tissue. The higher expression of elastic fibres provides passive energy to the cardiac scar tissue and results in prevention of ventricular remodelling

Secretome of apoptotic peripheral blood cells (APOSEC) confers cytoprotection to cardiomyocytes and inhibits tissue remodelling after acute myocardial infarction: a preclinical study

Heart failure following acute myocardial infarction (AMI) is a major cause of morbidity and mortality. Our previous observation that injection of apoptotic peripheral blood mononuclear cell (PBMC) suspensions was able to restore long-term cardiac function in a rat AMI model prompted us to study the effect of soluble factors derived from apoptotic PBMC on ventricular remodelling after AMI. Cell culture supernatants derived from irradiated apoptotic peripheral blood mononuclear cells (APOSEC) were collected and injected as a single dose intravenously after myocardial infarction in an experimental AMI rat model and in a porcine closed chest reperfused AMI model. Magnetic resonance imaging (MRI) and echocardiography were used to quantitate cardiac function. Analysis of soluble factors present in APOSEC was performed by enzyme-linked immunosorbent assay (ELISA) and activation of signalling cascades in human cardiomyocytes by APOSEC in vitro was studied by immunoblot analysis. Intravenous administration of a single dose of APOSEC resulted in a reduction of scar tissue formation in both AMI models. In the porcine reperfused AMI model, APOSEC led to higher values of ejection fraction (57.0 vs. 40.5%, p < 0.01), a better cardiac output (4.0 vs. 2.4 l/min, p < 0.001) and a reduced extent of infarction size (12.6 vs. 6.9%, p < 0.02) as determined by MRI. Exposure of primary human cardiac myocytes with APOSEC in vitro triggered the activation of pro-survival signalling-cascades (AKT, Erk1/2, CREB, c-Jun), increased anti-apoptotic gene products (Bcl-2, BAG1) and protected them from starvation-induced cell death. Intravenous infusion of culture supernatant of apoptotic PBMC attenuates myocardial remodelling in experimental AMI models. This effect is probably due to the activation of pro-survival signalling cascades in the affected cardiomyocytes

Generating forms of media capital inside and outside a field: the strange case of David Cameron in the UK political field

As societies become more ‘mediated’ so the elevation of public figures is increasingly linked to their ability to generate a positive public profile through the mass media. Politicians, artists, film stars, authors and others each gain professional status, in part, based on how consumer-citizens actively respond to media representations of themselves. The linking of media to individual celebrity and symbolic power is now implicit in much writing. Individuals succeed because of their personal charisma (Weber, 1948) and an innate ability to present a media personality that directly engages with large publics (Ankersmit, 1997; Horton and Wohl, 1993; Pels, 2003; Street, 2003). Alternatively, one’s symbolic image is primarily manufactured by promotional professionals (Boorstin, 1962; Evans, 2005; Franklin, 2004; Hall Jamieson, 1996; Lilleker and LeesMarshment, 2006) and parts of themedia industry itself (Evans and Hesmondhalgh, 2005; Turner, 2004). However one’s public image develops, media exposure then bestows a ‘primary definer’ status on those placed in positions of power thus drawing additional media coverage (Bennett, 1990; Champagne, 2005; Hall et al., 1978, Herman and Chomsky, 2002)

Understanding management gurus and historical narratives: The benefits of a historic turn in management and organization studies

A historic turn in organization studies requires a basic theoretical understanding of ‘doing history’ and an appreciation of the centrality of narrative in history. Following the cultural turn in history, narrativist historians and philosophers of history such as Hayden White, Frank Ankersmit and Paul Ricoeur have made the case that narrative is an essential and unavoidable component in history. We demonstrate the persuasive capacity of narrative through a narrativist critique of three best-selling ‘management gurus’. This analysis illustrates the following: (1) the narrative features of popular organizational theories; (2) the basis of the success of guru literature; and (3) why gurus and organizational scientists themselves do not understand the narratological mechanisms behind their success. Finally, we maintain that historical narrativism offers the possibility for positioning organizational history as a highly relevant field for management academics, gurus and even managers, providing support for a historic turn