An improved method for the synthesis of cyclopropyl ketoesters

A simple and versatile method for the synthesis of cyclopropyl ketoesters starting from chalcones and ethyl cyanoacetate in benzene using sodium powder as base is described

Synthesis in the field of podophyllotoxin and related analogues: Part X- Synthesis of indan analogue of tridemethoxy-β-apopicropodophyllin and ethyl-1-oxo-4-(3', 4', 5'-trimethoxyphenyl)-6, 7-trimethylene-1,2,3, 4-tetrahydro-3-naphthoate as an intermediate for indan analogue of β-apopicropodophyllin

572-57

Synthesis of podophyllotoxin and related analogues .9. Synthesis of ethylenedioxy and indan analogues of picropodophyllone and their antimitotic activity

Furo 3',4' : 6,7]-naphtho 2,3-e]-1, 4-dioxin-7-one-6, 6a-tetrahydro-10-one-6-phenyl (9) and furo 3', 4',:6, 7]-naphtho 2,3-d]-2,3-cyclopentenyl-6-one-5, 5a, 8, 8a-tetrahydro-9-one-5-phenyl (10) have been synthesised by bishydroxymethylation of tetralone acids (5 & 6) using formaldehyde in alkali followed by Jones oxidation using chromium trioxide in sulphuric acid

Synthesis of Podophyllotoxin Analogs with Modified Hydroaromatic Ring

Conversion of podophyllotoxone to podophyllohomotoxone and (4- spirooxymethylene)-desoxypodophyllotoxin by nitrosomethyl urea and S, S-dimethyl-N-(p-toluenesulphenyl) sulfoximine respectively is described. Conversion of beta- apopicropodophyllin to beta-apopicropodophyllone is also reported

Synthesis of podophyllotoxin and its analogues part-XI. Synthesis of analogues of β-apopicropodophyllin

Analogues (5,6,7) of β - apopicropodophyllin 2 have been synthesized from tetralone acid intermediates 8, 9 and 10 respectively

Synthesis in the field of podophyllotoxin and related analogues .10. Synthesis of indan analogue of tridemethoxy-beta-apopicropodophyllin and ethyl-1-oxo-4-(3',4',5'-trimethoxyphenyl)-6,7-trimethylene-1,2,3,4-tetra hydro-3-naphthoate as an intermediate for indan analogue of beta-apopicropodophyllin

The indan analogue 4 of DL-tridemethoxy-beta-apopicropodophyllin 3 has been synthesized starting from indan. The synthesis of ethyl 1-oxo-4-(3', 4', 5'-trimethoxyphenyl)-6, 7-trimethylene-1, 2, 3, 4-tetrahydro-3-naphthoate as an intermediate for indan analogue 5 of beta-apopicropodophyllin 2 has also been reported

<span style="font-size:20.5pt;mso-bidi-font-size:14.5pt">Synthesis of podophyllotoxin and related analogues: <span style="font-size:21.0pt;mso-bidi-font-size:15.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-US;mso-fareast-language: EN-US;mso-bidi-language:AR-SA;mso-bidi-font-weight:bold">Part<b> </b><span style="font-size:20.5pt;mso-bidi-font-size:14.5pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-US;mso-fareast-language: EN-US;mso-bidi-language:AR-SA">X -Tetralone esters as intermediates for synthesis of analogues of β<span style="font-size:17.5pt;mso-bidi-font-size: 11.5pt;font-family:HiddenHorzOCR;mso-hansi-font-family:"Times New Roman"; mso-bidi-font-family:HiddenHorzOCR;mso-ansi-language:EN-US;mso-fareast-language: EN-US;mso-bidi-language:AR-SA">-apopicropodophyllin</span></span></span></span>

137-140<span style="font-size:14.5pt;mso-bidi-font-size:8.5pt; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" mso-ansi-language:en-us;mso-fareast-language:en-us;mso-bidi-language:ar-sa"="">3-Ethy1carboxy-4-trimethoxyphenyl-6,7-dimethyl-methylenedioxy-1-tetralone 5 and 3-ethyl carboxy-4-trimethoxy phenyl-6,7-ethyl methyl-methylenedioxy-1-tetralone 6, intermediates for the synthesis of  analogues 3 and 4 respectively of  <span style="font-size:20.5pt; mso-bidi-font-size:14.5pt;font-family:" times="" new="" roman";mso-fareast-font-family:="" "times="" roman";mso-ansi-language:en-us;mso-fareast-language:en-us;="" mso-bidi-language:ar-sa"="">β<span style="font-size:12.5pt;mso-bidi-font-size: 6.5pt;font-family:HiddenHorzOCR;mso-hansi-font-family:" times="" new="" roman";="" mso-bidi-font-family:hiddenhorzocr;mso-ansi-language:en-us;mso-fareast-language:="" en-us;mso-bidi-language:ar-sa"="">-apopicropodophyllin <b style="mso-bidi-font-weight: normal"><span style="font-size:14.5pt;mso-bidi-font-size:8.5pt;font-family: " times="" new="" roman";mso-fareast-font-family:"times="" roman";mso-ansi-language:="" en-us;mso-fareast-language:en-us;mso-bidi-language:ar-sa"="">2 have been synthesised.</span