Developmental milestones of the autonomic nervous system revealed via longitudinal monitoring of fetal heart rate variability - Fig 1

<p><b>Developmental course of ACTAMP20 (a-c) and SDNN (d-f) in the linear mixed model.</b> (a, d) unclassified datasets, (b, e) fetal active sleep, (c, f) fetal quiescence. x–Segment of Interest {< 27 WGA; 27–30 WGA; 31–35 WGA; >35 WGA}; completed weeks of GA; y–Estimator in [ms] units. Numerical data see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0200799#pone.0200799.t002" target="_blank">Table 2</a>. Significant (p<0.05) contrasts are marked by *, trends (p<0.10) by +.</p

Developmental course of pNN5 in the linear mixed model.

<p>(a) unclassified datasets, (b) fetal active sleep, (c) fetal quiescence. x–Segment of Interest {< 27 WGA; 27–30 WGA; 31–35 WGA; >35 WGA}; completed weeks of GA; y–Estimator in [%]. Numerical data see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0200799#pone.0200799.t002" target="_blank">Table 2</a>. Significant (p<0.05) contrasts are marked by *, trends (p<0.10) by +.</p

Fetal state of activity.

<p>Fetal state of activity.</p

Population characteristics.

<p>Population characteristics.</p

Theorizing Ontology

University of California Santa Cruz (UCSC) Genome browser view (chr6:22308200–22348900) showing the position of single nucleotide polymorphisms (SNPs) rs9356811, rs10946546, rs9358531, rs9393273, rs12525289, rs12199382 and rs12524161. (DOC 261 kb

Additional file 10: Figure S2. of A comprehensive evaluation of interaction between genetic variants and use of menopausal hormone therapy on mammographic density

University of California Santa Cruz (UCSC) Genome browser view (chr6:22308200–22348900) showing the position of single nucleotide polymorphisms (SNPs) rs9356811, rs10946546, rs9358531, rs9393273, rs12525289, rs12199382 and rs12524161. (DOC 261 kb

The association between CRC and smoking (ever vs. never smokers [a]; pack-years of smoking [b]).

<p>Never smokers were assigned the value 0 for pack-years of smoking. OR: odds ratio; OR for pack-years of smoking is based on per 20 pack-years increase. Age, sex (if applicable), and study site (if applicable) were adjusted in model. ASTERISK: The French Association STudy Evaluating RISK for sporadic colorectal cancer; CCFR: Colon Cancer Family Registry; Colon23: Hawaii Colorectal Cancer Studies 2 and 3.; DACHS: Darmkrebs: Chancen der Verhütung durch Screening; DALS: Diet, Activity and Lifestyle Study; HPFS:Health Professionals Follow-up Study; HPFS_AD: Health Professionals Follow-up Study for colorectal adenoma; MEC: Multiethnic Cohort Study; NHS: Nurses’ Health Study; NHS_AD: Nurses’ Health Study for colorectal adenoma; OFCCR: Ontario Familial Colorectal Cancer Registry; PMH-CCFR: Postmenopausal Hormone study- Colon Cancer Family Registry; PLCO: Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial; VITAL: VITamins And Lifestyle; WHI: Women’s Health Initiative. CCFR is a collaborating study with GECCO. smk_ever: ever smokers; smk_pkyr20: pack-years of smoking; het.pval: p value of heterogeneity.</p

The association between CRC and alcohol consumption (non-/occasional drinkers [reference group]; light-to-moderate drinkers [a]; and heavy drinkers[b]).

<p>Men and women were analyzed separately in each study and age and study site (if applicable) were adjusted in model. Non-/occasional drinkers: drinking < 1 gram of alcohol per day; light-to-moderate drinkers: drinking 1–28 grams of alcohol per day ([a] alcoholc1-28g/d); and heavy drinkers: drinking >28 grams of alcohol per day ([b] alcoholc>28g/d). OR: odds ratio; N = total number of subjects; case = number of cases. Colon23: Hawaii Colorectal Cancer Studies 2 and 3; DACHS: Darmkrebs: Chancen der Verhütung durch Screening; DALS: Diet, Activity and Lifestyle Study; HPFS: Health Professionals Follow-up Study; HPFS_AD: Health Professionals Follow-up Study for colorectal adenoma; MEC: Multiethnic Cohort Study; NHS: Nurses’ Health Study; NHS_AD: Nurses’ Health Study for colorectal adenoma; PHS: Physicians’ Health Study; PLCO: Prostate, Lung, Colorectal and Ovarian Cancer; Screening Trial; VITAL: VITamins And Lifestyle; WHI: Women’s Health Initiative. het.pval: p value of heterogeneity.</p