Pim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasion

Conclusions: Altogether, our data indicate that DHPCC-9 is not only a powerful tool to investigate physiological effects of the oncogenic Pim family kinases, but also an attractive molecule for drug development to inhibit invasiveness of Pim-overexpressing cancer cells

Bicyclic 6-6 Systems: Other Four Heteroatoms 2/2.

International audienceThis chapter describes the theoretical studies, synthesis, reactivities and potential applications of bicyclic 6-6 systems (excluding pteridines) containing four heteroatoms (N, O, S) without any at the cyclic junction. Thus, work published since 2008 on various series such as pyrazinopyrazine, pyrimidopyrimidine, pyridazinopyridazine, pyrazinopyridazine, pyrimidopyridazine, pyridazinooxazine, pyrimidooxazine, pyrazinooxazine, pyridazinothiazine, pyrimidothiazine, pyrazinothiazine and oxazinooxazine are discussed

C3-indazole functionalization: a review

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A Journey in Heteroaromatic scaffolds as protein kinase inhibitors.

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Targeting kinases for the development of novel cancer and pain therapies.

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Biological evaluation of glycosyl-isoindigo derivatives against the pathogenic agents of tropical diseases (malaria, Chagas disease, leishmaniasis and human African trypanosomiasis)

The biological activities of diversely substituted glycosyl-isoindigo derivatives against the causative agents of tropical diseases (malaria, Chagas disease, leishmaniasis and human African trypanosomiasis) are reported. Some of the compounds tested showed interesting activities with good selectivity indices, particularly against Trypanosoma brucei rhodesiense. These results suggested, for the first time, that glycosyl-isoindigo derivatives could be of interest for the discovery of new lead compounds to treat tropical disease

Synthèse de glycosyl-indigos diversement substitués

Communication oral

Liposomal encapsulation of daunorubicin and an emetine prodrug for improved efficacy against acute myeloid leukaemia.

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Synthesis of specific inhibitors of Haspin for potential cancer treatment.

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