Bio-evaluation studies of phytoconstituents- A review of the patents granted and filed by CSIR

Botanicals have become a very important part of our life and are increasingly used as a primary source of actives in pharmaceuticals, cosmetics, nutraceuticals and personal care products. Extensive studies have been conducted on botanicals to understand their chemical profile and most of them have a history of safe use. Technical advances to isolate the bioactives, determine their molecular structure as well as their mechanism of action has generated considerable data and are available in the form of scientific publications as well as filing of patents. In this review, we aim to present the information pertaining to therapeutic applications of bioactives from different medicinal plants as disclosed in filed and granted patents to one of the largest publicly funded organizations in India namely Council of Scientific and Industrial Research (CSIR). The review also presents an assignee focused analysis and provides insights into the level of patent filing activity in the area of bioactives and the therapeutic applications by CSIR, India. Such information can provide a valuable tool for exploiting a firm’s portfolio of patent holdings to assist decision-makers to identify the most valuable patents; product area or business opportunities among its own patent holdings

Bio-evaluation studies of phytoconstituents- A review of the patents granted and filed by CSIR

434-450Botanicals have become a very important part of our life and are increasingly used as a primary source of actives in pharmaceuticals, cosmetics, nutraceuticals and personal care products. Extensive studies have been conducted on botanicals to understand their chemical profile and most of them have a history of safe use. Technical advances to isolate the bioactives, determine their molecular structure as well as their mechanism of action has generated considerable data and are available in the form of scientific publications as well as filing of patents. In this review, we aim to present the information pertaining to therapeutic applications of bioactives from different medicinal plants as disclosed in filed and granted patents to one of the largest publicly funded organizations in India namely Council of Scientific and Industrial Research (CSIR). The review also presents an assignee focused analysis and provides insights into the level of patent filing activity in the area of bioactives and the therapeutic applications by CSIR, India. Such information can provide a valuable tool for exploiting a firm’s portfolio of patent holdings to assist decision-makers to identify the most valuable patents; product area or business opportunities among its own patent holdings

Azaepothilone B and its derivatives: a patent review

<p><b>Introduction</b>: Azaepothilone B, also known as ixabepilone, is a semi synthetic second generation epothilone B analogue. Azaepothilone B, its derivatives, and analogues, are used for treating advance metastatic breast cancer. It has been used as a chemotherapeutic medication for cancer.</p> <p><b>Areas covered</b>: This review highlights the patents on different routes for synthesis of azaepothilone B, its derivatives and analogues. The review will also provide the reported pharmacological activity and its polymorphs in the treatment of several cancers, such as breast cancer (metastatic or locally advanced), non-Hodgkin’s lymphoma, and pancreatic cancer. In addition, it considers other proliferative diseases such as viral infections, degenerative diseases of the musculoskeletal system, kidney disease, and immune response related diseases. Different databases such as Espacenet, ISI Web of Knowledge, Patbase, and Thomson Innovation have been searched extensively to review the patents. The analysis has been done to indicate the patenting trend across years and the comparison of active assignees.</p> <p><b>Expert opinion</b>: Azaepothilone B, along with its derivatives and analogues, can damage cancer cells in very low concentrations and retain its activity when tumor cells are insensitive to paclitaxel. Hence, it is highly potent agent. Azaepothilone B alone, in combination with other chemotherapeutics, or in the form of formulations, led to applications in various types of cancer. Also, antiproliferative activity of azaepothilone B has great potential for the treatment of proliferative diseases, such as skin diseases and infections. Recent progress in synthesizing azaepothilone B has encouraged researchers to develop new methods for the synthesis of azaepothilone B, its derivatives, and analogues, to obtain maximum yield in minimum steps.</p