VARIOUS TECHNIQUES ENHANCING BIOAVAILABILTY OF POORLY WATER SOLUBLE DRUGS

A drug administered in solution form immediately available for absorption and efficiently absorbed than the same amount of drug administered in a tablet or capsule form. Solubility is a most important parameter for the oral bioavailability of poorly soluble drugs. Dissolution of drug is the rate determining step for oral absorption of the poorly water soluble drugs, which can subsequently affect the in vivo absorption of drug. Currently only 8% of new drug candidates have both high solubility and permeability. Because of solubility problem of many drugs the bioavailability of them gets affected and hence solubility enhancement becomes necessary. It is now possible that to increase the solubility of poorly soluble drugs with the help of various techniques such as Physical method,Chemical method. Co-crystallisation, co-solvency solubilizing agents, molecular encapsulation with cyclodextrins,nanotechnology approaches and hydrotropy. Key-Words: Solubility, Dissolution and Bioavailabilit

Magnetization hysteresis and time decay measurements in FeSe0.50_{0.50}Te0.50_{0.50} : Evidence for fluctuation in mean free path induced pinning

We present results of magnetic measurements relating to vortex phase diagram in a single crystal of FeSe$_{0.5}$Te$_{0.5}$ which displays second magnetization peak anomaly for $H \parallel c$. The possible role of the crystalline anisotropy on vortex pinning is explored via magnetic torque magnetometry. We present evidence in favor of pinning related to spatial variations of the charge carrier mean free path leading to small bundle vortex pinning by randomly distributed (weak) pinning centers for both $H \parallel c$ and $H \perp c$. This is further corroborated using magnetization data for $H \parallel c$ in a single crystal of FeSe$_{0.35}$Te$_{0.65}$. Dynamical response across second magnetization peak (SMP) anomaly in FeSe$_{0.5}$Te$_{0.5}$ has been compared with that across the well researched phenomenon of peak effect (PE) in a single crystal of CeRu$_2$.Comment: 11 figures, provided additional data in another sample, added Fig.

Comprehensive survey on nanobiomaterials for bone tissue engineering applications

One of the most important ideas ever produced by the application of materials science to the medical field is the notion of biomaterials. The nanostructured biomaterials play a crucial role in the development of new treatment strategies including not only the replacement of tissues and organs, but also repair and regeneration. They are designed to interact with damaged or injured tissues to induce regeneration, or as a forest for the production of laboratory tissues, so they must be micro-environmentally sensitive. The existing materials have many limitations, including impaired cell attachment, proliferation, and toxicity. Nanotechnology may open new avenues to bone tissue engineering by forming new assemblies similar in size and shape to the existing hierarchical bone structure. Organic and inorganic nanobiomaterials are increasingly used for bone tissue engineering applications because they may allow to overcome some of the current restrictions entailed by bone regeneration methods. This review covers the applications of different organic and inorganic nanobiomaterials in the field of hard tissue engineering

Biodegradable PEG-PCL Nanoparticles for Co-delivery of MUC1 Inhibitor and Doxorubicin for the Confinement of Triple-Negative Breast Cancer

Combating triple-negative breast cancer (TNBC) is still a problem, despite the development of numerous drug delivery approaches. Mucin1 (MUC1), a glycoprotein linked to chemo-resistance and progressive malignancy, is unregulated in TNBC. GO-201, a MUC1 peptide inhibitor that impairs MUC1 activity, promotes necrotic cell death by binding to the MUC1-C unit. The current study deals with the synthesis and development of a novel nano-formulation (DM-PEG-PCL NPs) comprising of polyethylene glycol-polycaprolactone (PEG-PCL) polymer loaded with MUC1 inhibitor and an effective anticancer drug, doxorubicin (DOX). The DOX and MUC1 loaded nanoparticles were fully characterized, and their different physicochemical properties, viz. size, shape, surface charge, entrapment efficiencies, release behavior, etc., were determined. With IC(50) values of 5.8 and 2.4 nm on breast cancer cell lines, accordingly, and a combination index (CI) of < 1.0, DM-PEG-PCL NPs displayed enhanced toxicity towards breast cancer cells (MCF-7 and MDA-MB-231) than DOX-PEG-PCL and MUC1i-PEG-PCL nanoparticles. Fluorescence microscopy analysis revealed DOX localization in the nucleus and MUC1 inhibitor in the mitochondria. Further, DM-PEG-PCL NPs treated breast cancer cells showed increased mitochondrial damage with enhancement in caspase-3 expression and reduction in Bcl-2 expression.In vivo evaluation using Ehrlich Ascites Carcinoma bearing mice explicitly stated that DM-PEG-PCL NPs therapy minimized tumor growth relative to control treatment. Further, acute toxicity studies did not reveal any adverse effects on organs and their functions, as no mortalities were observed. The current research reports for the first time the synergistic approach of combination entrapment of a clinical chemotherapeutic (DOX) and an anticancer peptide (MUC1 inhibitor) encased in a diblock PEG-PCL copolymer. Incorporating both DOX and MUC1 inhibitors in PEG-PCL NPs in the designed nanoformulation has provided chances and insights for treating triple-negative breast tumors. Our controlled delivery technology is biodegradable, non-toxic, and anti-multidrug-resistant. In addition, this tailored smart nanoformulation has been particularly effective in the therapy of triple-negative breast cancer. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10924-022-02654-4

Metal coordinated macrocyclic complexes in different chemical transformations

Macrocyclic ligand chemistry is seen by a growing number of scientists as a tool for designing new molecules with inherently selective properties. Metal coordinated macrocyclic rings are featured with exceptionally stable π-conjugated cyclic systems containing the metal ion in the central cavity. The cyclic tetra dentate framework of the four central nitrogen atoms makes these macrocyclic rings system unique chelating agents, in addition, these conjugated double bonds impart a vital effect in electrons transportation. Because of inimitable characteristics, these metal coordinated macrocyclic compounds have been effectively applied as catalysts in various important organic transformations. Hence, this review portrays the overview of metal coordinated macrocyclic molecules, classifications, and their catalytic application in redox reactions. This comprehensive and up-to-date review is particularly aligned toward the catalytic applications of four types of metal-coordinated macrocyclic rings, i.e., porphyrin, porphyrazine, corrole, and corrolazines, in different organic transformations. The different synthetic approaches for the preparation of metal coordinated macrocyclic rings and their UV spectrums are also outlined in this review

Interaction between Plate Make and Protein in Protein Crystallisation Screening

Background: Protein crystallisation screening involves the parallel testing of large numbers of candidate conditions with the aim of identifying conditions suitable as a starting point for the production of diffraction quality crystals. Generally, condition screening is performed in 96-well plates. While previous studies have examined the effects of protein construct, protein purity, or crystallisation condition ingredients on protein crystallisation, few have examined the effect of the crystallisation plate

Amorphous 1-propanol interstellar ice beyond its melting point

The recent discovery of 1-propanol (CH3CH2CH2OH) in the interstellar medium (ISM) is of tremendous interest since fatty alcohols have been proposed as constituents of proto-cell membranes. Motivated by this discovery, we present the laboratory midinfrared (MIR) and vacuum ultra-violet (VUV) absorption spectra of 1-propanol ice under astrochemical conditions, mimicking an icy mantle on cold dust in the ISM. Both MIR and VUV spectra were recorded at ultra-high vacuum (UHV) of ∼ 10-9 mbar and at temperatures ranging from 10 K to sublimation. The morphology of the 1-propanol ice deposited at 10 K was amorphous. By warming the ice to temperatures of 140 K and above, with subsequent recording of IR spectra, we observe complete sublimation of 1-propanol molecules from the substrate around 170 K. No amorphous-to-crystalline phase change was observed upon warming to higher temperatures. Additionally, We observe the IR and VUV signatures of 1-propanol ice on the substrate well beyond its melting point (147 K). To the best of our knowledge, this is the first reported observation of a molecular ice staying well beyond its melting point under such conditions. This result shows that the morphology of icy mantles on ISM cold dust grains is more complex than previously thought. Our atomistic molecular dynamics (MD) simulations capture the experimental trends and shed light on the microscopic origin of this unusual phase behaviour of 1-propanol

System of crop intensification for more productive, resource-conserving, climate-resilient, and sustainable agriculture: experience with diverse crops in varying agroecologies

With continually increasing demand for food accompanied by the constraints of climate change and the availability and quality of soil and water, the world’s farmers are challenged to produce more food per hectare with less water, and with fewer agrochemical inputs if possible. The ideas and methods of the system of rice intensification which is improving irrigated rice production are now being extended/adapted to many other crops: wheat, maize, finger millet, sugarcane, tef, mustard, legumes, vegetables, and even spices. Promoting better root growth and enhancing the soil’s fertility with organic materials are being found effective means for raising the yields of many crop plants with less water, less fertilizer, reduced seeds, fewer agrochemicals, and greater climate resilience. In this article, we review what is becoming known about various farmer-centred innovations for agroecological crop management that can contribute to agricultural sustainability. These changes represent the emerging system of crop intensification, which is being increasingly applied in Asian, African, and Latin American countries. More research will be needed to verify the efficacy and impact of these innovations and to clarify their conditions and limits. But as no negative effects for human or environmental health have been identified, making these agronomic options more widely known should prompt more investigation and, to the extent justified by results, utilization of these methodologies

Understanding our seas: National Institute of Oceanography, Goa

The present article summarizes the research done at the CSIR–National Institute of Oceanography in 2014 in ocean science, resources and technology. Significant research has been conducted on air–sea interactions and coastal circulation, biogeochemistry, biology, marine geophysics, palaeoceanography, marine fishery, gas hydrates and wave energy. Technological advances covered topics like oceanographic tools. Major strides have been made in marine resources research and evaluation

Understanding our seas: National Institute of Oceanography, Goa

The present article summarizes the research done at the CSIR–National Institute of Oceanography in 2014 in ocean science, resources and technology. Significant research has been conducted on air–sea interactions and coastal circulation, biogeochemistry, biology, marine geophysics, palaeoceanography, marine fishery, gas hydrates and wave energy. Technological advances covered topics like oceanographic tools. Major strides have been made in marine resources research and evaluation