655 research outputs found
Experimental and theoretical studies of sequence effects on the fluctuation and melting of short DNA molecules
Understanding the melting of short DNA sequences probes DNA at the scale of
the genetic code and raises questions which are very different from those posed
by very long sequences, which have been extensively studied. We investigate
this problem by combining experiments and theory. A new experimental method
allows us to make a mapping of the opening of the guanines along the sequence
as a function of temperature. The results indicate that non-local effects may
be important in DNA because an AT-rich region is able to influence the opening
of a base pair which is about 10 base pairs away. An earlier mesoscopic model
of DNA is modified to correctly describe the time scales associated to the
opening of individual base pairs well below melting, and to properly take into
account the sequence. Using this model to analyze some characteristic sequences
for which detailed experimental data on the melting is available [Montrichok et
al. 2003 Europhys. Lett. {\bf 62} 452], we show that we have to introduce
non-local effects of AT-rich regions to get acceptable results. This brings a
second indication that the influence of these highly fluctuating regions of DNA
on their neighborhood can extend to some distance.Comment: To be published in J. Phys. Condensed Matte
Quasi two-dimensional antiferromagnet on a triangular lattice RbFe(MoO4)2
RbFe(MoO4)2 is a rare example of a nearly two-dimensional Heisenberg
antiferromagnet on a triangular lattice. Magnetic resonance spectra and
magnetization curves reveal that the system has a layered spin structure with
six magnetic sublattices. The sublattices within a layer are arranged in a
triangular manner with the magnetization vectors 120 degree apart. The H-T
phase diagram, containing at least five different magnetic phases is
constructed. In zero field, RbFe(MoO4)2 undergoes a phase transition at T_N=3.8
K into a non-collinear triangular spin structure with all the spins confined in
the basal plane. The application of an in-plane magnetic field induces a
collinear spin state between the fields H_c1=47 kOe and H_c2=71 kOe and
produces a magnetization plateau at one-third of the saturation moment. Both
the ESR and the magnetization measurements also clearly indicate an additional
first-order phase transition in a field of 35 kOe. The exact nature of this
phase transition is uncertain.Comment: 9 pages incl 11 figure
Spin physics with antiprotons
New possibilities arising from the availability at GSI of antiproton beams,
possibly polarised, are discussed. The investigation of the nucleon structure
can be boosted by accessing in Drell-Yan processes experimental asymmetries
related to cross-sections in which the parton distribution functions (PDF) only
appear, without any contribution from fragmentation functions; such processes
are not affected by the chiral suppression of the transversity function
. Spin asymmetries in hyperon production and Single Spin Asymmetries
are discussed as well, together with further items like electric and magnetic
nucleonic form factors and open charm production. Counting rates estimations
are provided for each physical case. The sketch of a possible experimental
apparatus is proposed.Comment: Presented for the proceedings of ASI "Spin and Symmetry", Prague,
July 5-10, 2004, to be published in Czech. J. Phys. 55 (2005
Transition Radiation Spectroscopy with Prototypes of the ALICE TRD
We present measurements of the transition radiation (TR) spectrum produced in
an irregular radiator at different electron momenta. The data are compared to
simulations of TR from a regular radiator.Comment: 4 pages, 5 Figures, Proceedings for "TRDs for the 3rd millennium"
(Sept. 4-7, 2003, Bari, Italy
Collective behaviour of partons could be a source of energetic hadrons
We discuss the idea that collective behaviour of the quarks/partons, which
has been intensely discussed for the last 40 years in relativistic
hadron-nuclear and nuclear-nuclear interactions and confirmed by new data
coming from the ultrarelativistic heavy ion collisions, can lead to energetic
particle production. Created from hadronization of the quark/parton (or
quarks/partons), energetic particles could get the energy of grouped partons
from coherent interactions. Therefore, we think that in the centre of some
massive stars, a medium with high density, close to Quantum Chromodynamic one
could be a source of the super high-energy cosmic rays.Comment: 8 pages, 8 figure
γ-Catenin-Dependent Signals Maintain BCR-ABL1<sup>+</sup> B Cell Acute Lymphoblastic Leukemia.
The BCR-ABL1 fusion protein is the cause of chronic myeloid leukemia (CML) and of a significant fraction of adult-onset B cell acute lymphoblastic leukemia (B-ALL) cases. Using mouse models and patient-derived samples, we identified an essential role for γ-catenin in the initiation and maintenance of BCR-ABL1 <sup>+</sup> B-ALL but not CML. The selectivity was explained by a partial γ-catenin dependence of MYC expression together with the susceptibility of B-ALL, but not CML, to reduced MYC levels. MYC and γ-catenin enabled B-ALL maintenance by augmenting BIRC5 and enforced BIRC5 expression overcame γ-catenin loss. Since γ-catenin was dispensable for normal hematopoiesis, these lineage- and disease-specific features of canonical Wnt signaling identified a potential therapeutic target for the treatment of BCR-ABL1 <sup>+</sup> B-ALL
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