21 research outputs found

    INFUSION PRESSURE CONTROL SYSTEM

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    An infusion pressure control system for ophthalmic surgery includes: - intraocular pressure detection means; - arterial pressure detection means; and a control unit operatively connected to said intraocular pressure detection means and said arterial pressure detection means and configured for calculating the mean ocular perfusion pressure value based on the intraocular pressure and arterial pressure values provided by said intraocular pressure detection means and by said arterial pressure detection means, and for comparing said calculated mean ocular perfusion pressure value and at least one predetermined threshold value

    SISTEMA E METODO DI CONTROLLO DELLA PRESSIONE DI INFUSIONE OCULARE PER INTERVENTI DI CHIRURGIA OFTALMICA

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    La presente invenzione riguarda un sistema ed un metodo di controllo della pressione di infusione oculare per interventi di chirurgia oftalmica

    Increased FGF23 serum level is associated with unstable carotid plaque in type 2 diabetic subjects with internal carotid stenosis.

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    BACKGROUND: The object of this study was to investigate the potential role of FGF23 on plaque stability in type 2 diabetic patients with internal carotid artery stenosis. METHODS: In this retrospective observational study, we analyzed FGF23 serum level in 361 type 2 diabetic patients with internal carotid artery stenosis undergoing carotid endarterectomy and in 598 diabetic controls without carotid atherosclerosis. RESULTS: We found that FGF23 median serum levels was significantly higher in patients than in diabetic controls [67.7 (59.5-77.8) pg/mL and 43.89 (37.5-50.4), P < 0.001] and was significantly and independently associated with unstable plaque in patients with internal carotid artery stenosis [OR, 5,71 (95% CI, 2.09-15.29]. CONCLUSIONS: We have found, for the first time, that FGF23 could be associated with unstable plaque in type 2 diabetic patients with internal carotid artery stenosis

    La Retorica, fra etica e politica

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    Questo volume parte da una serie di problematiche che, riprendendo delle espressioni comunemente in uso, si addensano sull’etica e sulla politica dello Stagirita: che cos’è l’etica? Che cos’è la politica? Qual è il loro fine? A chi si riferiscono? Qual è il collegamento tra le due? Ma ancora, passando ai trattati, qual è il rapporto tra le Etiche e la Politica sia in sé che rispetto alla continuità e discontinuità di certi temi? Oltre alla questione della scienza – che, al di là della sistematizzazione consueta, non è assolutamente scontata –, si tratta però di concentrarsi anche su tutti quei temi che si impongono sempre in un’interrogazione di questo tipo, interrogazione che deve sempre tenere presente la specificità storico-categoriale del pensiero dello Stagirita. Anche per questo, piuttosto che offrire una semplice ricostruzione, qui si cercherà di complicare il più possibile questo nodo, che, come si vedrà, è tutto tranne che risolto. Saggi di: Giulia Angelini, Claudia Baracchi, Manuel Berrón, Enrico Berti, Michele Di Febo, Silvia Gullino, Alberto Jori, Pietro Li Causi, Giovanni Battista Magnoli Bocchi, Francesca Masi, Marcello Zanatta

    Co-Occurrence of Beckwith–Wiedemann Syndrome and Early-Onset Colorectal Cancer

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    CRC is an adult-onset carcinoma representing the third most common cancer and the second leading cause of cancer-related deaths in the world. EO-CRC (KCNQ1OT1:TSS-DMR that leads to bi-allelic expression of the lncRNA KCNQ1OT1 and BWSp. Our results support the hypothesis that the inherited CFTR mutations, together with constitutional loss of methylation of the KCNQ1OT1:TSS-DMR, initiate the tumorigenesis process. Further somatic genetic and epigenetic changes enhancing the activation of the WNT/beta-catenin pathway likely contributed to increase the growth advantage of cancer cells. Although this study does not provide any conclusive cause–effect relationship between BWSp and CRC, it is tempting to speculate that the imprinting defect of BWSp might accelerate tumorigenesis in adult cancer in the presence of predisposing genetic variants
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