Quantification of fluorochrome accumulation in a double xenografted mouse by FMT

Fluorescence-mediated tomography (FMT) was performed 24 hours after injection of SIDAG in order to resolve the three-dimensional fluorochrome distribution and for quantification of fluorochrome concentration in the target tissue: panel a shows a white light image, panel b shows colour-coded FMT data for MDA-MB435, and panel c shows the DU4475 xenograft superimposed on white light images. The average fluorochrome concentration in the MDA-MB xenografts ranged around 229 ± 90 nmol/l, whereas DU4475 exhibited significantly lesser fluorochrome accumulation (49 ± 22 nmol/l; < 0.01).<p><b>Copyright information:</b></p><p>Taken from "Differentiation of angiogenic burden in human cancer xenografts using a perfusion-type optical contrast agent (SIDAG)"</p><p>http://breast-cancer-research.com/content/10/2/R23</p><p>Breast Cancer Research : BCR 2008;10(2):R23-R23.</p><p>Published online 10 Mar 2008</p><p>PMCID:PMC2397521.</p><p></p