Synthesis and photodynamic potential of tetra-and octa-triethyleneoxysulfonyl substituted zinc phthalocyanines

Synthesis of the water soluble zinc phthalocyanines (3, 4) obtained from the phthalonitriles substituted with oligo(ethyleneoxy)thia groups are described. The new compounds have been characterized by elemental analysis, IR, 1H and 13C NMR spectroscopy, including HSQC, HMBC and COSY bidimensional correlation techniques, electronic spectroscopy and mass spectra. The aggregation behaviour of the phthalocyanine compounds (3, 4) was investigated using UV–vis spectroscopy in dimethylsulphoxide. Photochemical and photophysical measurements were conducted on oligo(ethyleneoxy)thia appended zinc phthalocyanines. General trends are described for quantum yields of photodegredation, fluorescence yields, triplet lifetimes and triplet quantum yields as well as singlet oxygen quantum yields of these compounds. The phototoxicity against cancer cells of the new compounds was investigated during several in vitro experiments. The dye-sensitized photooxidation of 1,3-diphenylisobenzofurane via 1O2 was studied in dimethylsulphoxide

spectroscopy and

time-correlated single photon counting technique fo

Fast-tunable femtosecond visible radiation via sum-frequency generation from a high power NIR NOPO

We report on a high power ultra-broadband, quickly tunable non-collinear parametric oscillator with highly efficient intra-cavity sum-frequency generation. It simultaneously delivers femtosecond pulses in two synchronized output beams: up to 4.9 W tunable from 650 to 1050 nm in the near infrared and up to 1.9 W from 380 to 500 nm in the visible spectral range. The (to our knowledge) novel source is ideally suited for spectroscopy or multi-color imaging. First results of two-color functional microscopy are presented

Genome-wide association study of panic disorder reveals geneticoverlap with neuroticism and depression

Panic disorder (PD) has a lifetime prevalence of 2–4% and heritability estimates of 40%. Thecontributory genetic variants remainlargely unknown, with few and inconsistent loci having been reported. The present report describes the largest genome-wide associationstudy (GWAS) of PD to date comprising genome-wide genotype data of 2248 clinically well-characterized PD patients and 7992ethnically matched controls. The samples originated from four European countries (Denmark, Estonia, Germany, and Sweden).Standard GWAS quality control procedureswere conducted on each individual dataset, and imputation was performed using the 1000Genomes Project reference panel. A meta-analysis was then performed using the Ricopili pipeline. No genome-wide significant locuswas identified. Leave-one-out analyses generated highly significant polygenic risk scores (PRS) (explained variance of up to 2.6%).Linkage disequilibrium (LD) score regression analysis of the GWAS data showed that the estimated heritability for PD was28.0–34.2%. After correction for multiple testing, a significant genetic correlation was foundbetween PD and major depressivedisorder, depressive symptoms, and neuroticism. A total of 255 single-nucleotide polymorphisms (SNPs) withp<1×10−4werefollowed up in an independent sample of 2408 PD patients and 228,470controls from Denmark, Iceland and the Netherlands. In thecombined analysis, SNP rs144783209 showed the strongest association with PD (pcomb=3.10 × 10−7). Sign tests revealed asignificant enrichment of SNPs with a discoveryp-value of <0.0001 in the combined follow up cohort (p=0.048). The presentintegrative analysis represents a major step towards the elucidation of the genetic susceptibility to PD