Borderline Personality Disorder With Cocaine Dependence: Impulsivity, Emotional Dysregulation and Amygdala Functional Connectivity

Background: Borderline personality disorder is present in 19% of cocaine dependence cases; however, this dual pathology is poorly understood. We wished to characterize the dual pathology and find its functional connectivity correlates to better understand it.Methods: We recruited 69 participants divided into 4 groups: dual pathology (n = 20), cocaine dependence without borderline personality disorder (n = 19), borderline personality without cocaine dependence (n = 10) and healthy controls (n = 20). We used self-reported instruments to measure impulsivity and emotional dysregulation. We acquired resting state fMRI and performed seed-based analyses of the functional connectivity of bilateral amygdala.Results: Borderline personality disorder and cocaine dependence as factors had opposing effects in impulsivity and emotional dysregulation, as well as on functional connectivity between left amygdala and medial prefrontal cortex. On the other hand, in the functional connectivity between right amygdala and left insula, the effect of having both disorders was instead additive, reducing functional connectivity strength. The significant functional connectivity clusters were correlated with impulsivity and emotional dysregulation.Conclusions: In this study, we found that clinical scores of dual pathology patients were closer to those of borderline personality disorder without cocaine dependence than to those of cocaine dependence without borderline personality disorder, while amygdala-medial prefrontal cortex functional connectivity patterns in dual pathology patients were closer to healthy controls than expected

Focal electrical stimulation on an alcohol disorder model using magnetic resonance imaging-compatible chronic neural monopolar carbon fiber electrodes

Neuromodulation interventions, such as Deep Brain Stimulation (DBS) and repeated transcranial magnetic stimulation (rTMS), are proposed as possible new complementary therapies to treat substance use disorders (SUD) such as alcohol use disorder (AUD). It is hypothesized that neuromodulation may induce neural plasticity in the reward and frontostriatal systems via electrical field induction, possibly reducing symptoms. Preclinical self-administration rodent models of AUD may help us gain insight into the effects of neuromodulation therapies on different pathology, as well as the neural mechanisms behind the positive effects. DBS, or any type of brain stimulation using intracranial electrodes in rodents, would benefit from the use of magnetic resonance imaging (MRI) to study the longitudinal effects and mechanisms of stimulation as well as novel targets, as it is a non-invasive technique that allows the analysis of structural and functional changes in the brain. To do this, there is a need for MRI-compatible electrodes that allow for MRI acquisition with minimal distortion of the magnetic field. In this protocol, we present a method for the construction and surgery of chronically implantable monopolar carbon electrodes for use in rats. Unlike conventional electrodes, carbon electrodes are resistant to high temperatures, flexible, and generate fewer artifacts in MRI compared to conventional ones. We validated its use by using a focal electrical stimulation high-frequency (20 Hz) protocol that lasted ∼10 sessions. We propose that this technique can also be used for the research of the neurophysiological bases of the neuromodulatory treatment in other preclinical substance use disorders (SUD) models

The Mexican dataset of an rTMS clinical trial on cocaine use disorder patients: SUDMEX TMS

<p>The SUDMEX_TMS dataset is the result of a longitudinal clinical trial of cocaine use disorder patients that were treated with rTMS at 5-Hz on the left dorsolateral prefrontal cortex (lDLPFC) for a 2 week double-blind acute phase and an open-label maintenance phase that included clinical, cognitive and MRI data acquisition. The design was a double-blind placebo-controlled randomized controlled trial with parallel groups (acute phase). The study was done at the National Institute of Psychiatry .</p> <p>Each patient had more than one clinical and MRI session or time point from baseline (T0), 2 weeks (T1), 3 months (T2), 6 months (T3) and some patients had 12 months (T4). The T14 time point was only for patients in the Sham group who decided to continue the clinical trial with open-label rTMS. The T14 refers to 2 weeks after T1 (4 weeks after T0).</p> <p>The MRI sequences were: 1) T1-weighted, 2) rsfMRI 10 min, 3) HARDI-DWI multishell (next release).</p> <p>The data set is curated and organized by test and item for each experimental phase and also has a dictionary to define the variables measured.</p> <p> </p> <p>If you require more information about data or scales, please contact us. </p> <p><em>LANIREM (</em><em>National MRI Laboratory)</em><em>, Institute of Neurobiology, </em></p> <p><em>Universidad Nacional Autónoma de México (UNAM), </em><em>Querétaro, México.</em></p> <p><strong>Diego Angeles Valdez, M. Sc. </strong></p> <ul> <li>[email protected]</li> <li>[email protected]</li> </ul> <p><br> <strong>Eduardo A. Garza-Villarreal, M.D., Ph.D.</strong></p> <ul> <li>[email protected]</li> <li>[email protected]</li> </ul&gt

Table_2_Borderline Personality Disorder With Cocaine Dependence: Impulsivity, Emotional Dysregulation and Amygdala Functional Connectivity.DOCX

<p>Background: Borderline personality disorder is present in 19% of cocaine dependence cases; however, this dual pathology is poorly understood. We wished to characterize the dual pathology and find its functional connectivity correlates to better understand it.</p><p>Methods: We recruited 69 participants divided into 4 groups: dual pathology (n = 20), cocaine dependence without borderline personality disorder (n = 19), borderline personality without cocaine dependence (n = 10) and healthy controls (n = 20). We used self-reported instruments to measure impulsivity and emotional dysregulation. We acquired resting state fMRI and performed seed-based analyses of the functional connectivity of bilateral amygdala.</p><p>Results: Borderline personality disorder and cocaine dependence as factors had opposing effects in impulsivity and emotional dysregulation, as well as on functional connectivity between left amygdala and medial prefrontal cortex. On the other hand, in the functional connectivity between right amygdala and left insula, the effect of having both disorders was instead additive, reducing functional connectivity strength. The significant functional connectivity clusters were correlated with impulsivity and emotional dysregulation.</p><p>Conclusions: In this study, we found that clinical scores of dual pathology patients were closer to those of borderline personality disorder without cocaine dependence than to those of cocaine dependence without borderline personality disorder, while amygdala-medial prefrontal cortex functional connectivity patterns in dual pathology patients were closer to healthy controls than expected.</p

Table_1_Borderline Personality Disorder With Cocaine Dependence: Impulsivity, Emotional Dysregulation and Amygdala Functional Connectivity.DOCX

<p>Background: Borderline personality disorder is present in 19% of cocaine dependence cases; however, this dual pathology is poorly understood. We wished to characterize the dual pathology and find its functional connectivity correlates to better understand it.</p><p>Methods: We recruited 69 participants divided into 4 groups: dual pathology (n = 20), cocaine dependence without borderline personality disorder (n = 19), borderline personality without cocaine dependence (n = 10) and healthy controls (n = 20). We used self-reported instruments to measure impulsivity and emotional dysregulation. We acquired resting state fMRI and performed seed-based analyses of the functional connectivity of bilateral amygdala.</p><p>Results: Borderline personality disorder and cocaine dependence as factors had opposing effects in impulsivity and emotional dysregulation, as well as on functional connectivity between left amygdala and medial prefrontal cortex. On the other hand, in the functional connectivity between right amygdala and left insula, the effect of having both disorders was instead additive, reducing functional connectivity strength. The significant functional connectivity clusters were correlated with impulsivity and emotional dysregulation.</p><p>Conclusions: In this study, we found that clinical scores of dual pathology patients were closer to those of borderline personality disorder without cocaine dependence than to those of cocaine dependence without borderline personality disorder, while amygdala-medial prefrontal cortex functional connectivity patterns in dual pathology patients were closer to healthy controls than expected.</p

The Mexican magnetic resonance imaging dataset of patients with cocaine use disorder: SUDMEX CONN

Cocaine use disorder (CUD) is a substance use disorder (SUD) characterized by compulsion to seek, use and abuse of cocaine, with severe health and economic consequences for the patients, their families and society. Due to the lack of successful treatments and high relapse rate, more research is needed to understand this and other SUD. Here, we present the SUDMEX CONN dataset, a Mexican open dataset of 74 CUD patients (9 female) and matched 64 healthy controls (6 female) that includes demographic, cognitive, clinical, and magnetic resonance imaging (MRI) data. MRI data includes: 1) structural (T1-weighted), 2) multishell high-angular resolution diffusion-weighted (DWI-HARDI) and 3) functional (resting state fMRI) sequences. The repository contains unprocessed MRI data available in brain imaging data structure (BIDS) format with corresponding metadata available at the OpenNeuro data sharing platform. Researchers can pursue brain variability between these groups or use a single group for a larger population sample

SUDMEX_CONN: The Mexican dataset of cocaine use disorder patients.

The SUDMEX_CONN is a Mexican open dataset of CUD patients and matched healthy controls that includes demographic, cognitive, clinical and magnetic resonance imaging (MRI) data. The study was done at the National Institute of Psychiatry in Mexico City The MRI sequences are available  at https://openneuro.org/datasets/ds003346/versions/1.1.1 If you require more information about data or scales, please contact us.  LANIREM (National MRI Laboratory), Institute of Neurobiology,  Universidad Nacional Autónoma de México (UNAM), Querétaro, México. Diego Angeles Valdez, M. Sc. [email protected] [email protected] Eduardo A. Garza-Villarreal, M.D., Ph.D. [email protected] [email protected]   Updates October 11-12, 2022 The MINI PLUS was coded to reflect all the possible answers we had for questions about substance use as columns. For example, if the patient said to use more than 1 hallucinogen, we would mark the first one in Mini.L1.d1, then d2 is the second hallucinogen, then d3 is the third one. We updated the databases of the variables Addiction Severity Index (ASI), Barratt's Impulsivity Scale version 11 (BIS-11). and Clinical Global Impressions (CGI) Scale.  

SUDMEX_CONN: The Mexican dataset of cocaine use disorder patients.

The SUDMEX_CONN is a Mexican open dataset of CUD patients and matched healthy controls that includes demographic, cognitive, clinical and magnetic resonance imaging (MRI) data. The study was done at the National Institute of Psychiatry in Mexico City The MRI sequences are available  at https://openneuro.org/datasets/ds003346/versions/1.1.1 If you require more information about data or scales, please contact us.  LANIREM (National MRI Laboratory), Institute of Neurobiology,  Universidad Nacional Autónoma de México (UNAM), Querétaro, México. Diego Angeles Valdez, M. Sc. [email protected] [email protected] Eduardo A. Garza-Villarreal, M.D., Ph.D. [email protected] [email protected]   Updates October 11, 2022 The MINI PLUS was coded to reflect all the possible answers we had for questions about substance use as columns. For example, if the patient said to use more than 1 hallucinogen, we would mark the first one in Mini.L1.d1, then d2 is the second hallucinogen, then d3 is the third one