A cluster randomised controlled trial of the clinical and cost-effectiveness of a 'whole systems' model of self-management support for the management of long- term conditions in primary care: trial protocol

BackgroundPatients with long-term conditions are increasingly the focus of quality improvement activities in health services to reduce the impact of these conditions on quality of life and to reduce the burden on care utilisation. There is significant interest in the potential for self-management support to improve health and reduce utilisation in these patient populations, but little consensus concerning the optimal model that would best provide such support. We describe the implementation and evaluation of self-management support through an evidence-based 'whole systems' model involving patient support, training for primary care teams, and service re-organisation, all integrated into routine delivery within primary care.MethodsThe evaluation involves a large-scale, multi-site study of the implementation, effectiveness, and cost-effectiveness of this model of self-management support using a cluster randomised controlled trial in patients with three long-term conditions of diabetes, chronic obstructive pulmonary disease (COPD), and irritable bowel syndrome (IBS). The outcome measures include healthcare utilisation and quality of life. We describe the methods of the cluster randomised trial.DiscussionIf the 'whole systems' model proves effective and cost-effective, it will provide decision-makers with a model for the delivery of self-management support for populations with long-term conditions that can be implemented widely to maximise 'reach' across the wider patient population.Trial registration numberISRCTN: ISRCTN9094004

Minimally invasive total knee replacement : techniques and results

In this review, we outlined the definition of minimally invasive surgery (MIS) in total knee replacement (TKR) and described the different surgical approaches reported in the literature. Afterwards we went through the most recent studies assessing MIS TKR. Next, we searched for potential limitations of MIS knee replacement and tried to answer the following questions: Are there selective criteria and specific patient selection for MIS knee surgery? If there are, then what are they? After all, a discussion and conclusion completed this article. There is certainly room for MIS or at least less invasive surgery (LIS) for appropriate selected patients. Nonetheless, there are differences between approaches. Mini medial parapatellar is easy to master, quick to perform and potentially extendable, whereas mini subvastus and mini midvastus are trickier and require more caution related to risk of hematoma and VMO nerve damage. Current evidence on the safety and efficacy of mini-incision surgery for TKR does not appear fully adequate for the procedure to be used without special arrangements for consent and for audit or continuing research. There is an argument that a sudden jump from standard TKR to MIS TKR, especially without computer assistance such as navigation, patient specific instrumentation (PSI) or robotic, may breach a surgeon's duty of care toward patients because it exposes patients to unnecessary risks. As a final point, more evidence is required on the long-term safety and efficacy of this procedure which will give objective shed light on real benefits of MIS TKR

Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study

Introduction: The multiorgan impact of moderate to severe coronavirus infections in the post-acute phase is still poorly understood. We aimed to evaluate the excess burden of multiorgan abnormalities after hospitalisation with COVID-19, evaluate their determinants, and explore associations with patient-related outcome measures. Methods: In a prospective, UK-wide, multicentre MRI follow-up study (C-MORE), adults (aged ≥18 years) discharged from hospital following COVID-19 who were included in Tier 2 of the Post-hospitalisation COVID-19 study (PHOSP-COVID) and contemporary controls with no evidence of previous COVID-19 (SARS-CoV-2 nucleocapsid antibody negative) underwent multiorgan MRI (lungs, heart, brain, liver, and kidneys) with quantitative and qualitative assessment of images and clinical adjudication when relevant. Individuals with end-stage renal failure or contraindications to MRI were excluded. Participants also underwent detailed recording of symptoms, and physiological and biochemical tests. The primary outcome was the excess burden of multiorgan abnormalities (two or more organs) relative to controls, with further adjustments for potential confounders. The C-MORE study is ongoing and is registered with ClinicalTrials.gov, NCT04510025. Findings: Of 2710 participants in Tier 2 of PHOSP-COVID, 531 were recruited across 13 UK-wide C-MORE sites. After exclusions, 259 C-MORE patients (mean age 57 years [SD 12]; 158 [61%] male and 101 [39%] female) who were discharged from hospital with PCR-confirmed or clinically diagnosed COVID-19 between March 1, 2020, and Nov 1, 2021, and 52 non-COVID-19 controls from the community (mean age 49 years [SD 14]; 30 [58%] male and 22 [42%] female) were included in the analysis. Patients were assessed at a median of 5·0 months (IQR 4·2–6·3) after hospital discharge. Compared with non-COVID-19 controls, patients were older, living with more obesity, and had more comorbidities. Multiorgan abnormalities on MRI were more frequent in patients than in controls (157 [61%] of 259 vs 14 [27%] of 52; p<0·0001) and independently associated with COVID-19 status (odds ratio [OR] 2·9 [95% CI 1·5–5·8]; padjusted=0·0023) after adjusting for relevant confounders. Compared with controls, patients were more likely to have MRI evidence of lung abnormalities (p=0·0001; parenchymal abnormalities), brain abnormalities (p<0·0001; more white matter hyperintensities and regional brain volume reduction), and kidney abnormalities (p=0·014; lower medullary T1 and loss of corticomedullary differentiation), whereas cardiac and liver MRI abnormalities were similar between patients and controls. Patients with multiorgan abnormalities were older (difference in mean age 7 years [95% CI 4–10]; mean age of 59·8 years [SD 11·7] with multiorgan abnormalities vs mean age of 52·8 years [11·9] without multiorgan abnormalities; p<0·0001), more likely to have three or more comorbidities (OR 2·47 [1·32–4·82]; padjusted=0·0059), and more likely to have a more severe acute infection (acute CRP >5mg/L, OR 3·55 [1·23–11·88]; padjusted=0·025) than those without multiorgan abnormalities. Presence of lung MRI abnormalities was associated with a two-fold higher risk of chest tightness, and multiorgan MRI abnormalities were associated with severe and very severe persistent physical and mental health impairment (PHOSP-COVID symptom clusters) after hospitalisation. Interpretation: After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeutic stratification

Biomechanical analysis of the sit-to-stand movement following knee replacement : a cross-sectional observational study

The sit-to-stand [STS] movement is a functional task that generates large forces across the knee. Only a few studies have reported biomechanical variables during this movement in post knee replacement patients and none have compared these variables between unilateral and bilateral sub groups. The aim of this study was to provide a biomechanical characterisation of the STS movement post knee arthroplasty and explore differences between bilateral and unilateral patients. Sixteen post arthroplasty patients [age 67.3 +/- 4.95, height, 164cm+/- 10.1, weight 80.8Kg +/-15.0] were recruited from the same clinical site and underwent biomechanical analysis 7.9 +/- 6.92 months after surgery. Participants performed the STS movement from a set position without using their arms. Movement variables [movement time, joint rotation, peak force, loading symmetry and knee moments] were derived from a three dimensional motion analysis system. The bilateral group (n=7) performed the movement slightly faster (n/s) with better loading symmetry (mean 0.91 compared to 0.78) but smaller knee moments (mean 0.38 Nm kg-1 compared to 0.49 Nm kg-1) than the unilateral group (n=9). These results confirm patients with a knee replacement perform the STS movement differently to healthy older adults and provide comparisons between bilateral and unilateral patients

Hands-on defibrillation: theoretical and practical aspects of patient and rescuer safety

Defibrillators are used to treat many thousands of people each year using very high voltages, but, despite this, reported injuries to rescuers are rare. Although even a small number of reported injuries is not ideal, the safety record of the defibrillator using the current protocol is widely regarded as being acceptable.There is increasing evidence that clinical outcome is significantly improved with continuous chest compressions, but defibrillation is a common cause of interruptions; even short interruptions, such as those associated with defibrillation, may detrimentally affect the outcome. This has led to discussions regarding the possibility of continuing chest compressions during defibrillation; a process involving a rescuer working in close proximity to voltages of up to 5000 V.Not only do voltages of this magnitude have significant implications for the rescuer performing chest compressions, but there are also risks to other rescuers in the proximity, the patient and other bystanders. Clearly any deviation from accepted practice should only be undertaken following careful consideration of the risks and benefits to the patient, rescuers and others.This review summarises the physical principles of electrical risk and identifies ways in which these could be managed. In doing so, it is hoped that in future it may be possible to deliver continuous and safe manual chest compressions during defibrillator discharge in order to improve patient outcome

Using navigation intraoperative measurements narrows range of outcomes in TKA

UNLABELLED: Computer-assisted technology creates a new approach to total knee arthroplasty (TKA). The primary purpose of this technology is to improve component placement and soft tissue balance. We asked whether the use of navigation techniques would lead to a narrow range of implant alignment in both coronal and sagittal planes and throughout the flexion-extension range. Using a prospective consecutive series of 57 navigated TKAs, we assessed intraoperative knee measurements, including alignment, varus-valgus stress angles in extension, and varus-valgus angles from 0 degrees to 90 degrees of flexion comparing postimplant with preimplant. We found fewer outliers with coronal (100% of TKAs within +/-2 degrees) and sagittal (0% of TKAs with fixed flexion greater than 5 degrees) alignment, soft tissue balancing (mean varus and valgus stress angles -3.2 degrees and 2.3 degrees; range, -5 degrees to 5 degrees), and mean femorotibial angle over flexion range 0 degrees (-0.2 degrees; range, -1 degrees to 2 degrees), 30 degrees (-0.2 degrees; range, -5 degrees to 4 degrees), 60 degrees (-0.5 degrees; range, -5 degrees to 7 degrees), and 90 degrees (-0.2 degrees; range, -5 degrees to 10 degrees). This technology allows a narrow range of implant placement and soft tissue management in extension. We anticipate improved ultimate patient outcomes with less tissue disruption. LEVEL OF EVIDENCE: Level IV, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence

Visualisation of total knee replacement rehabilitation exercises in the home

Postoperative rehabilitation after total knee replacement (TKR) within the UK usually takes place within the home. Sometimes patients find it difficult to monitor the quality and quantity of their exercises, and it is important to achieve as good a range of movement as possible in the first few weeks. This work aimed to engage users in their rehabilitation through an innovative way of capturing and then visualising movement data. Primary unilateral TKR patients were recruited to a single centre randomised controlled pilot trial. The control group underwent normal post-operative rehabilitation with an exercise booklet and DVD. The intervention group were provided with the visualisation system to use in their homes. The system consisted of two wireless sensors, a remote control, bespoke software and a laptop. The patient wore one sensor above the knee and one below while performing the rehabilitation exercises. A colour coded interactive traffic light system and stickman figure was used to indicate the quality of movement and the number of repetitions of each exercise. The system tracked weekly progress (both quality and quantity of exercises completed) and allowed arthroplasty practitioners to hold video calls with patients. The outcome measures for the study were gait speed, timed up and go test, knee range of motion and Oxford Knee Score. These were collected immediately prior to discharge (baseline) and at six weeks follow up. As this was a pilot study only descriptive statistics (mean ± SD) were used. Twenty-four patients were recruited. Of these six withdrew and two were excluded (one readmit and one referral for outpatient physiotherapy). Seven control and nine intervention patient completed the study. The mean age was 69 years (47 to 85), 6 left and 10 right knees, 10 females and 6 males. All intervention patients who completed the study found the visualisation system and video call easy to use. There were similar improvements in both groups from baseline to six-week follow-up for the gait speed (Control = 0.6 m/s ± 0.2, Intervention = 0.6 m/s ± 0.3), the timed up and go test (Control = 16 s ± 12, Intervention = 16 s ± 12) and for the Oxford Knee Score (Control = 17 ± 8, Intervention = 20 ± 10). However, the intervention group had larger improvements in knee extension (Control = 1° ± 3, Intervention = 6° ± 5) and knee flexion (Control = 15° ± 14, Intervention = 22° ± 12). This pilot study shows that a home-based visualisation system using wireless sensors can be introduced into patients’ post-operative rehabilitation and can also be used to facilitate remote assessment sessions with trained professionals. This approach is generally acceptable and could potentially improve patients’ knee range of motion, most especially in reducing knee extension lag

Identification of a Novel and Selective Series of Itk Inhibitors via a Template-Hopping Strategy

Inhibition of Itk potentially constitutes a novel, nonsteroidal treatment for asthma and other T-cell mediated diseases. In-house kinase cross-screening resulted in the identification of an aminopyrazole-based series of Itk inhibitors. Initial work on this series highlighted selectivity issues with several other kinases, particularly AurA and AurB. A template-hopping strategy was used to identify a series of aminobenzothiazole Itk inhibitors, which utilized an inherently more selective hinge binding motif. Crystallography and modeling were used to rationalize the observed selectivity. Initial exploration of the SAR around this series identified potent Itk inhibitors in both enzyme and cellular assays