Correction: Influence of Obesity and Metabolic Disease on Carotid Atherosclerosis in Patients with Coronary Artery Disease (CordioPrev Study).

[This corrects the article DOI: 10.1371/journal.pone.0153096.]

Inclusion and exclusion criteria for CORDIOPREV study.

<p>Inclusion and exclusion criteria for CORDIOPREV study.</p

Influence of metabolic phenotypes on IMT-CC of coronary patients in the CordioPrev study.

<p>All data are Mean +/- SEM (mm). Columns which do not share at least one letter are different at p<0.05. Sample size for the different groups is as follows: Metabolically healthy normal-weight (n = 36); metabolically sick normal-weight (n = 22); metabolically healthy overweight (n = 136); metabolically sick overweight (n = 221); metabolically healthy obese subjects (n = 122); metabolically sick obese subjects (n = 402). Specific p values for the different significant comparisons are as follows: Metabolically healthy normal-weight subjects are different to metabolically sick normal-weight (p = 0.0036), metabolically sick overweight (p = 0.0134) and metabolically sick obese subjects (p = 0.0048); Metabolically healthy overweight subjects are different to metabolically sick normal-weight (p = 0.0014), metabolically sick overweight (p = 0.0004) and metabolically sick obese subjects (p = 0.0001).</p

Influence of weight and metabolic disease on IMT-CC of coronary patients in the CordioPrev study.

<p>All data are Mean +/- SEM (mm). Panel A: IMT-CC of patients with and without metabolic disease (adjusted by age and gender). *p 1.7+10⁻⁶. Panel B: Influence of weight in three categories (normal, overweight and obese). Panel C: Influence of weight in two categories (not obese versus obese).** p 0.016.</p

Baseline.

<p>Baseline.</p

Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries

Background Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks. Methods The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned. Results A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P &lt; 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31). Conclusion Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)