SUICIDAL PHENOMENON IN PANDEMIC TIMES .THE TRENTINO\u27S REALITY

Suicide is a major public health problem; according to the latest WHO data, it is among the top twenty causes of death in the world. After the sudden and unexpected spreading of a global pandemic in 2020, many mental health researchers have launched alarms about a possible suicide rates\u27 rise, due to the inevitable consequences of the ongoing social and health emergency. However, recent articles in scientific literature have disconfirmed this thesis. Trentino also seems not to deviate from this dynamic: preliminary data, collected in an unconventional, and not yet official way, have been able to show that in 2020 the suicide rate remained stable. The finding that excludes up to date such a rise in rates does not unfortunately provide any guarantee that the situation will remain constant over time, and that there cannot be significant differences regarding gender, ethnicity, religious faith, sexual orientation or social class in determining a different impact of the current crisis on the suicidal phenomenon. Further studies and insights into the processing of the data in our possession are needed. Difficulties and uncertainties connected to the covid-19, with which it is now clear that the community will have to "learn to live together", could also in the medium and long term constitute a prolonged stressgenerating element with a greater negative impact on the mental health of the population. It is essential, in light of the particular social and health situation we are experiencing, to carry out with even greater effectiveness, precision and continuity actions such as those promoted within the Invito alla Vita Project for the prevention of suicide, in order to guarantee the most effective prevention of this serious phenomenon. The psychological and social implications of the covid-19 pandemic will only be fully assessable in a few years, when the crisis will be effectively over. Only then we will be able to understand if the efforts put in place at a global level, and in particular in the province of Trento, have been effective in the managing of the suicidal phenomenon

SUICIDAL PHENOMENON IN PANDEMIC TIMES .THE TRENTINO\u27S REALITY

Suicide is a major public health problem; according to the latest WHO data, it is among the top twenty causes of death in the world. After the sudden and unexpected spreading of a global pandemic in 2020, many mental health researchers have launched alarms about a possible suicide rates\u27 rise, due to the inevitable consequences of the ongoing social and health emergency. However, recent articles in scientific literature have disconfirmed this thesis. Trentino also seems not to deviate from this dynamic: preliminary data, collected in an unconventional, and not yet official way, have been able to show that in 2020 the suicide rate remained stable. The finding that excludes up to date such a rise in rates does not unfortunately provide any guarantee that the situation will remain constant over time, and that there cannot be significant differences regarding gender, ethnicity, religious faith, sexual orientation or social class in determining a different impact of the current crisis on the suicidal phenomenon. Further studies and insights into the processing of the data in our possession are needed. Difficulties and uncertainties connected to the covid-19, with which it is now clear that the community will have to "learn to live together", could also in the medium and long term constitute a prolonged stressgenerating element with a greater negative impact on the mental health of the population. It is essential, in light of the particular social and health situation we are experiencing, to carry out with even greater effectiveness, precision and continuity actions such as those promoted within the Invito alla Vita Project for the prevention of suicide, in order to guarantee the most effective prevention of this serious phenomenon. The psychological and social implications of the covid-19 pandemic will only be fully assessable in a few years, when the crisis will be effectively over. Only then we will be able to understand if the efforts put in place at a global level, and in particular in the province of Trento, have been effective in the managing of the suicidal phenomenon

SUICIDE AND ATTEMPTED SUICIDE: EPIDEMIOLOGICAL SURVEILLANCE AS A CRUCIAL MEANS OF A LOCAL SUICIDE PREVENTION PROJECT IN TRENTO’S PROVINCE

The World Health Organization identifies suicide among the top 10 causes of death in many countries with an overall mortality rate of 16 per 100,000 inhabitants. Furthermore suicide attempts present a frequency 4-10 times greater than the suicidal events, representing also one of the main risk factors to lead to recurrent attempts of suicide. In 2008 the Autonomous Province of Trento launched a suicide prevention pogram called "Invitation to Life" which includes various interventions intended to counter the phenomenon of suicide in the region. Actually the epidemiological research upon the phenomenon of suicide in Trentino region is one of the main pillars of the project: it represents a fundamental requirement to identify risk and protective factors in the population in order to adopt more specific and effective preventive strategies. This article aims to present methods and instruments for epidemiological monitoring of suicide and attempted suicide which are applied in Trentino and to describe results after seven years from the beginning of the local prevention program “Invitation to life”

p63 Promotes Cell Survival through Fatty Acid Synthase

There is increasing evidence that p63, and specifically ΔNp63, plays a central role in both development and tumorigenesis by promoting epithelial cell survival. However, few studies have addressed the molecular mechanisms through which such important function is exerted. Fatty acid synthase (FASN), a key enzyme that synthesizes long-chain fatty acids and is involved in both embryogenesis and cancer, has been recently proposed as a direct target of p53 family members, including p63 and p73. Here we show that knockdown of either total or ΔN-specific p63 isoforms in squamous cell carcinoma (SCC9) or immortalized prostate epithelial (iPrEC) cells caused a decrease in cell viability by inducing apoptosis without affecting the cell cycle. p63 silencing significantly reduced both the expression and the activity of FASN. Importantly, stable overexpression of either FASN or myristoylated AKT (myr-AKT) was able to partially rescue cells from cell death induced by p63 silencing. FASN induced AKT phosphorylation and a significant reduction in cell viability was observed when FASN-overexpressing SCC9 cells were treated with an AKT inhibitor after p63 knockdown, indicating that AKT plays a major role in FASN-mediated survival. Activated AKT did not cause any alteration in the FASN protein levels but induced its activity, suggesting that the rescue from apoptosis documented in the p63-silenced cells expressing myr-AKT cells may be partially mediated by FASN. Finally, we demonstrated that p63 and FASN expression are positively associated in clinical squamous cell carcinoma samples as well as in the developing prostate. Taken together, our findings demonstrate that FASN is a functionally relevant target of p63 and is required for mediating its pro-survival effects

Tumor-associated and immunochemotherapy-dependent long-term alterations of the peripheral blood NK cell compartment in DLBCL patients

Natural Killer (NK) cells are a key component of tumor immunosurveillance and thus play an important role in rituximab-dependent killing of lymphoma cells via an antibody-dependent cellular cytotoxicity (ADCC) mechanism. We evaluated the phenotypic and functional assets of peripheral blood NK cell subsets in 32 newly-diagnosed diffuse large B-cell lymphoma (DLBCL) patients and in 27 healthy controls. We further monitored long-term modifications of patient NK cells for up to 12 months after rituximab-based immunochemotherapy. At diagnosis, patients showed a higher percentage of CD56dim and CD16C NK cells, and a higher frequency of GrzBC cells in CD56dim, CD56bright, and CD16C NK cell subsets than healthy controls. Conversely, DLBCL NK cell killing and interferon g (IFNg) production capability were comparable to those derived from healthy subjects. Notably, NK cells from refractory/relapsed patients exhibited a lower “natural” cytotoxicity. A marked and prolonged therapy-induced reduction of both “natural” and CD16- dependent NK cytotoxic activities was accompanied by the down-modulation of CD16 and NKG2D activating receptors, particularly in the CD56dim subset. However, reduced NK cell killing was not associated with defective lytic granule content or IFNg production capability. This study firstly describes tumor-associated and therapy-induced alterations of the systemic NK cell compartment in DLBCL patients. As these alterations may negatively impact rituximab-based therapy efficacy, our work may provide useful information for improving immunochemotherapeutic strategies

Gestational Diabetes Mellitus pregnancy by pregnancy. early, late and nonrecurrent GDM

Aims: To assess the GDM recurrence rate in a cohort of pregnant women with prior GDM, to compare two consecutive pregnancies complicated by GDM, to compare women with nonrecurrent and recurrent GDM and to stratify the latter in women with early and late recurrent GDM.Methods: Retrospective study including 113 women with GDM in an index pregnancy (G1), at least a postindex pregnancy (G2) and normal glucose tolerance in between. The GDM recurrence rate was assessed, and maternal and neonatal outcomes and pancreatic beta cell function of the index pregnancy were compared with those of the postindex pregnancy (G1 vs. G2). Women with nonrecurrent GDM were compared with those with recurrent GDM.Results: The GDM recurrence rate was 83.2% and the minimum prevalence of early recurrent GDM was 43,4%. The pregravid BMI of women with recurrent GDM increased between the two pregnancies (27.3 +/- 5.98 vs. 28.1 +/- 6.19 kg/m(2), p < 0.05). Women with recurrent GDM had a higher prepregnancy BMI than those with nonrecurrent GDM either at the index (27.3 +/- 5.98 vs. 23.1 +/- 4.78 kg/m(2), p < 0.05) or the postindex pregnancy (27 +/- 6vs.24 +/- 4,4 kg/m2, p < 0.05).Conclusions: GDM shows a high recurrence rate in our cohort of slightly overweight women, with an early GDM minimum prevalence of 43.4%

The selective effect of lockdown experience on citizens' perspectives: A multilevel, multiple informant approach to personal and community resilience during COVID-19 pandemic

In the face of the first wave of COVID-19 contagion, citizens all over the world experienced concerns for their safety and health, as well as prolonged lockdowns – which brought about limitations but also unforeseen opportunities for personal growth. Broad variability in these psychological responses to such unprecedented experiences emerged. This study addresses this variability by investigating the role of personal and community resilience. Personal resilience, collective resilience, community disaster management ability, provided information by local authorities, and citizens' focus on COVID-19-related personal concerns and lockdown-related opportunities for personal growth were detected through an online questionnaire. Multilevel modelling was run with data from 3,745 Italian citizens. The potential of personal resilience as a driver for individuals to overcome adverse situations with positive outcomes was confirmed. Differently, the components of community resilience showed more complex paths, highlighting the need to pay more attention to its role in the face of far-reaching adverse events which hardly test individuals' as well as communities' adaptability and agency skills. The complexities linked to the multi-component and system-specific nature of resilience, as well as potential paths towards making the most out of citizens' and communities' ones, emerge. The theoretical and practical implications are discussed

Emergency online school learning during COVID-19 lockdown: A qualitative study of adolescents' experiences in Italy

The COVID-19 pandemic caused abrupt and profound changes to teaching and learning. The present study seeks to understand adolescents' experiences of the emergency adoption of online school learning (OSL) during the first national lockdown in Italy. Sixty-four students in their final two years of high school were interviewed and content analysis was performed. The findings describe students' views of the changes related to OSL according to structural, individual and relational dimensions. Schools' lack of organization, overwhelming demands, as well as experience of difficulties in concentration, stress and inhibited relationships with teachers and classmates were among the challenges evidenced in the transition. OSL, however, has also made it possible to experience a new flexibility and autonomy in the organization of learning. The study stresses the importance of fostering adaptation of teacher-student relationships and collaborative learning in order to improve schools' preparedness for digital transitions in and out of emergencies