Modelling of heat emitters embedded within third order lumped parameter building envelope model

A dynamic modelling approach for heat emitters embedded within an existing third order lumped parameter building envelope model is reported in this work. The model has been found to provide more accurate results with negligible expense of computational time compared to a conventional quasi-dynamic model. The dynamic model also is preferred over the quasi-dynamic model as it allows for modelling emitters with high thermal capacity such as under-floor heating. Recommendation for this approach is justified through a series of analyses and comparative tests for various circuit options, timesteps and control volumes

Application of a new dynamic heating system model using a range of common control strategies

This research investigates the overall heating energy consumptions using various control strategies, secondary heat emitters, and primary plant for a building. Previous research has successfully demonstrated that a dynamic distributed heat emitter model embedded within a simplified third-order lumped parameter building model is capable of achieving improved results when compared to other commercially available modelling tools. With the enhanced ability to capture transient effects of emitter thermal capacity, this research studies the influence of control strategies and primary plant configurations on the rate of energy consumption of a heating system. Four alternative control strategies are investigated: zone feedback; weather-compensated; a combination of both of these methods; and thermostatic control. The plant alternative configurations consist of conventional boilers, biomass boilers, and heat pumps supporting radiator heating and underfloor heating. The performance of the model is tested on a primary school building and can be applied to any residential or commercial building with a heating system. Results show that the new methods reported offer greater detail and rigor in the conduct of building energy modelling

Design of higher education teaching models and carbon impacts

Purpose This research examines the main findings of the SusTEACH study of the carbon-based environmental impacts of 30 higher education (HE) courses in 15 UK institutions, based on an analysis of the likely energy consumption and carbon emissions of a range of Face-to-face, Distance, Online and ICT-enhanced blended teaching models. Design/methodology/approach An environmental assessment of 19 campus-based and 11 distance-based HE courses was conducted using questionnaire surveys to gather data from students and lecturers on course-related travel; the purchase and use of Information and Communication Technologies (ICTs) and paper materials; residential energy consumption, and campus site operations. Results were converted into average energy and CO2 emissions, normalised per student per 100 study hours, and then classified by the primary teaching model used by lecturers. Findings The main sources of HE course carbon emissions were travel; residential energy consumption; and campus site operations. Distance-based HE models (Distance, Online and ICT-enhanced teaching models) reduced energy consumption by 88% and achieved significant carbon reductions of 83% when compared with campus-based HE models (Face-to-face and ICT-enhanced teaching models). The Online teaching model achieved the lowest energy consumption and carbon emissions, although there were potential rebound effects associated with increased ICT-related energy consumption and paper used for printing. Practical implications New pedagogical designs using online and distance-based teaching methods can achieve carbon reductions by reducing student travel, residential and campus accommodation. Originality/value Few studies have examined the environmental performance of HE teaching models. A new classification of HE traditional, online and blended teaching models is used to examine the role of ICTs and the likely carbon impacts

Parity and Components of the Metabolic Syndrome Among US Hispanic/Latina Women

BACKGROUND: Physiological adaptations occurring across successive pregnancies may increase the risk of adverse cardiovascular health outcomes in later life. METHODS AND RESULTS: The association between parity and metabolic syndrome was examined among 7467 Hispanic/Latina women of diverse backgrounds, aged 18 to 74 years, who participated in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) from 2008 to 2011. Metabolic syndrome components were defined according to American Heart Association/National Heart, Lung, and Blood Institute criteria and included abdominal obesity, elevated triglycerides, low high-density lipoprotein cholesterol, high blood pressure, and elevated fasting glucose. Logistic regression models estimated odds ratios (ORs) adjusting for sociodemographic, behavioral, and reproductive characteristics. At HCHS/SOL baseline, women reported none (21.1%), 1 (19.9%), 2 (25.7%), 3 (18.6%), 4 (8.8%), and ≥ 5 (5.9%) live births. When compared with women with 1 birth, those with 4 births had the highest odds of abdominal obesity (OR, 2.0; 95% confidence interval, 1.5-2.8) and overall metabolic syndrome (OR, 1.4; 95% confidence interval, 1.0-2.0) and those with ≥ 5 births had the highest odds of low high-density lipoprotein cholesterol (OR, 1.5; 95% confidence interval, 1.2-2.0) and elevated fasting glucose (OR, 1.6; 95% confidence interval, 1.1-2.4), after adjusting for age, background, education, marital status, income, nativity, smoking, physical activity, menopause, oral contraceptive use, hormone therapy, and field center. Further adjustment for percent body fat attenuated these associations. No associations were observed between parity and elevated triglycerides or high blood pressure. CONCLUSIONS: Higher parity is associated with an increased prevalence of selected components of the metabolic syndrome among Hispanic/Latina women in the US. High parity among Hispanics/Latinas with a high prevalence of abdominal obesity suggests high risk for metabolic dysregulation

GUDMAP - An Online GenitoUrinary Resource

The GenitoUrinary Development Molecular Anatomy Project (GUDMAP) is a consortium of laboratories working to provide the scientific and medical community with gene expression data and tools to facilitate research (see "www.gudmap.org":http://www.gudmap.org). The data provided by GUDMAP includes large _in situ_ hybridization screens (wholemount and section) and expression microarray analysis of components of the developing mouse urogenital system (including laser-captured material and FACS-isolated cells from transgenic reporter mice). In addition, a high-resolution anatomy ontology has been developed by members of the GUDMAP consortium to describe the subcompartments of the developing murine genitourinary tract. 

The GUDMAP Database Development Team and Editorial Office - both based in Edinburgh - function to ensure submission, curation, storage and presentation of the data submitted by the GUDMAP consortium. Our collective aim is twofold: 1) to simplify the process of submission so that data is publically available as soon as it is produced; and 2) to organize this information in a database and ensure that the online interface is continuously available and easy to use. Thus far, we have developed a range of tools that help both the submitter and the end user. These include: an online annotation tool that simplifies _in situ_ data submission through an ontology-based graphical user interface; a database interface that allows users to browse and query expression data, and to filter data by organ system; a heat-map display of microarray data and analyses. Furthermore, the Edinburgh team has developed a GUDMAP Disease Database that queries associations between genes, genitourinary diseases, and renal/urinary and reproductive phenotypes. In collaboration with GUDMAP consortium members at the CCHMC (Cincinnati Children's Hospital Medical Center), the Disease Database is being extended to include mammalian phenotypes mapped to OMIM entries. 

By virtue of its impressive dataset and its ease of use we hope that the GUDMAP Website will continue to serve as a powerful resource for biologists, clinicians and bioinformaticians with an interest in the urogenital system

Passage and concentration-dependent effects of Indomethacin on tendon derived cells

<p>Abstract</p> <p>Background</p> <p>Non-steroidal anti-inflammatory drugs (NSAID) are commonly used in the treatment of tendinopathies such as tendonitis and tendinosis. Despite this, little is known of their direct actions on tendon-derived cells. As NSAIDs have been shown to delay healing in a number of mesenchymal tissues we have investigated the direct effects of indomethacin on the proliferation of tendon-derived cells.</p> <p>Results and Discussion</p> <p>The results obtained were dependent on both the type of cells used and the method of measurement. When measured using the Alamar blue assay, a common method for the measurement of cell proliferation and viability, no effect of indomethacin was seen regardless of cell source. It is likely that this lack of effect was due to a paucity of mitochondrial enzymes in tendon cells.</p> <p>However, when cell number was assessed using the methylene blue assay, which is a simple nuclear staining technique, an Indomethacin-induced inhibition of proliferation was seen in primary cells but not in secondary subcultures.</p> <p>Conclusion</p> <p>These results suggest that firstly, care must be taken when deciding on methodology used to investigate tendon-derived cells as these cells have a quite different metabolism to other mesenchymal derive cells. Secondly, Indomethacin can inhibit the proliferation of primary tendon derived cells and that secondary subculture selects for a population of cells that is unresponsive to this drug.</p

"Just an excuse people are just using these days":Attending to and managing interactional concerns in talk on exclusion of immigrants

In line with discursive work on the role of constructions of minority groups in social exclusion, we offer an examination of talk on immigrants and its links with employment of British residents, in the UK Parliament and interview talk with British residents looking for work, in the context of a financial crisis (2007-09). Discursive analysis of data shows that parliamentarians treat immigration as problematic for British residents’ employment, whereas interviewees’ responses reject or minimally accept this, while displaying sensitivity to the status of this as a prevalent complaint about immigration. Parliamentarians do so to warrant and challenge or manage challenges to Government’s policies, whereas interviewees do so to manage being seen as discriminatory and work-shy. These findings show that constructions of immigration and its links with employment in the context of the financial crisis, and, their use in warrants for exclusion are offered in ways to attend to the situated institutional and interactional relevancies in play for interlocutors