35 research outputs found
Proceedings of the 5th Annual United States Army Institute of Surgical Research Summer Undergraduate Research Internship Program 2017
“Awake” extracorporeal membrane oxygenation (ECMO): pathophysiology, technical considerations, and clinical pioneering
Update on the role of extracorporeal CO2 removal
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2015 and co-published as a series in Critical Care. Other articles in the series can be found online at http://ccforum.com/series/annualupdate2015. Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www.springer.com/series/8901
Update on the Role of Extracorporeal CO2 Removal as An Adjunct to Mechanical Ventilation in ARDS.
peer reviewedVeno-venous CO2 removal therapy enabled protective ventilation while maintaining normocarbia during ARDS. CO2 removal decreased pulmonary hypertension and improved RV function. This technique may be an effective lung- and RV- protective adjunct to mechanical ventilation
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In vivo detection of inhalation injury in large airway using three-dimensional long-range swept-source optical coherence tomography.
We report on the feasibility of using long-range swept-source optical coherence tomography (OCT) to detect airway changes following smoke inhalation in a sheep model. The long-range OCT system (with axial imaging range of 25 mm) and probe are capable of rapidly obtaining a series of high-resolution full cross-sectional images and three-dimensional reconstructions covering 20-cm length of tracheal and bronchial airways with airway diameter up to 25 mm, regardless of the position of the probe within the airway lumen. Measurements of airway thickness were performed at baseline and postinjury to show mucosal thickness changes following smoke inhalation
In vivo detection of inhalation injury in large airway using three-dimensional long-range swept-source optical coherence tomography.
We report on the feasibility of using long-range swept-source optical coherence tomography (OCT) to detect airway changes following smoke inhalation in a sheep model. The long-range OCT system (with axial imaging range of 25 mm) and probe are capable of rapidly obtaining a series of high-resolution full cross-sectional images and three-dimensional reconstructions covering 20-cm length of tracheal and bronchial airways with airway diameter up to 25 mm, regardless of the position of the probe within the airway lumen. Measurements of airway thickness were performed at baseline and postinjury to show mucosal thickness changes following smoke inhalation
Combat casualties undergoing lifesaving interventions have decreased heart rate complexity at multiple time scales
Surface Modification of Oxygenator Fibers with a Catalytically Active Metal–Organic Framework to Generate Nitric Oxide: An Ex Vivo Pilot Study
Coating all portions of an extracorporeal membrane oxygenation
(ECMO) circuit with materials exhibiting inherent, permanent antithrombotic
properties is an essential step to prevent thrombus-induced complications.
However, developing antithrombotic coatings for oxygenator fibers
within membrane oxygenators of ECMO systems has proven challenging.
We have used polydopamine (PDA) to coat oxygenator fibers and immobilize
a Cu-based metal–organic framework (MOF) on the surface to
act as a nitric oxide (NO) catalyst. Importantly, the PDA/MOF coating
will produce NO indefinitely from endogenous S-nitrosothiols
and it has not previously been applied to ECMO oxygenator fibers