Report of the International Society for Zinc Biology 5th Meeting, in Collaboration with Zinc-Net (COST Action TD1304)-UCLan Campus, Pyla, Cyprus

From 18 to 22 June 2017, the fifth biennial meeting of the International Society for Zinc Biology was held in conjunction with the final dissemination meeting of the Network for the Biology of Zinc (Zinc-Net) at the University of Central Lancashire, Cyprus campus. The meeting attracted over 160 participants, had 17 scientific symposia, 4 plenary speakers and 2 poster discussion sessions. In this report, we give an overview of the key themes of the meeting and some of the highlights from the scientific programme

The influence of workaholism and burnout on the intention to quite amongst academic employees at a selected university n the Western Cape

Magister Commercii (Industrial Psychology) - MCom(IPS)Universities worldwide have to contend with a changing landscape due to the massification of education, additional pressure being placed on academia with respect to research outputs, teaching a transforming student base, along with political and social pressures. In South Africa, in particular, there has been increasing pressure on government to effect socio-political and legislative changes to ensure that those that were previously disadvantaged are granted free educational opportunities. Within an academic milieu, talent retention of staff at higher education institutions (HEIs) in South Africa has become a challenge. Research highlights many changes in the nature of work over the past few decades, including an increasingly prevalent culture of long working hours and increasing work intensity across many sectors. Within academia, recent research indicates a culture of increasing work intensity over time often combined with decreasing resources and competing demands. Once assumed to be a low-pressure job, research reports that significant mind set shifts have been needed within academia in order to cope with the heavy workloads, administrative, teaching, community outreach and publishing requirements and expectations within this group of employees. These additional expectations are likely to result in burnout, which is defined as a prolonged response or “‘psychological syndrome’” in response to chronic interpersonal stressors on the job. Burnout affects all professions but tends to be more pervasive in human service occupations such as education. Despite this evident recognition, there is a paucity of research on burnout among South African academics. Amongst the studies conducted, however, evidence suggests that burnout is escalating, and consequently academic careers are becoming less attractive. The extant research reveals that the repercussions of burnout are accompanied by declines in mental and physical health, low morale, substance abuse, weakening of interpersonal relationships, deterioration in teaching and research performance, increased absenteeism and ultimately considerations of leaving the profession. This is likely to be exacerbated in those academics who display a propensity towards workaholism. Workaholism has become a prevalent phenomenon within organisations, which needs to be managed more effectively to offset its damaging effects on employee health and productivity. Associations have been established between workaholism, absenteeism, psychological ill -health, physical ill ill-health, stress and burnout. Faced with increasing professional and operational challenges, academics may develop the resultant impact and be inclined to intend to quit. The main objective of the research study was to determine the relationship between workaholism and burnout on the intention to quit amongst academic employees at a uUniversity in the Western Cape. A quantitative method was used to generate the result by means of survey distribution to the targeted population. Convenience sampling was used to select academic staff in the study. Questionnaires were sent electronically and an additional one hundred and fifty 150 hardcopy questionnaires were administered. Fifty-three responses were received electronically, and fifty-three53 hardcopy completed questionnaires. In total, one hundred and six106 questionnaires were completed, of which one hundred 100 questionnaires were used for the study. The surveys included a biographical questionnaire, Workaholism Analysis Questionnaire (WAQ) (2013), the Maslach Burnout Inventory (MBI) (1981) and the Turnover Intentions Questionnaire (TIQ) (2008). The results indicated that there is a significant positive relationship between Eemotional Eexhaustion and turnover, Eemotional Eexhaustion and workaholism, Ddepersonalisation and workaholism, and workaholism and turnover intention. In addition, the results further indicated a strong negative relationship between Ppersonal Aaccomplishment and Tturnover Iintention. The results further showed that a medium positive relationship between Ddepersonalisation and turnover intention exists. The regression analysis indicated that a significant proportion of the variance in turnover intention is explained by Eemotional Eexhaustion. Conclusions were drawn, and recommendations are made to the uUniversity in order to address this potential problem

Majestic Gamification:a case study in the adoption of a service innovation

Purpose: A case study is presented concerning a gamified awards system designed to encourage software users to explore a suite of tools, and to share their expertise level in profile pages. Majestic is a high-tech business based in the West Midlands (UK) w hich offers a Link Intelligence database using a Software as a Service (SaaS) business model. Customers leverage the database for tasks including Search Engine Optimisation (SEO) by using a suite of web-based tools. Getting to know all the tools and how they can be deployed to good effect represents a considerable learning challenge, and Majestic were aware that. Design/methodology/approach: We present the development of Majestic Awards as a case study highlighting the most important design decisions. Then we reflect on the development process as an example of innovation adoption, thereby identifying resources and cu ltura l factors which were critical in ensuring the success of the project. Findings: The gamified awards system makes learning the tools an enjoyable, explorative experience. Success factors included identifying a clear business goal, the process/ project f it, senior management buy in, and identifying the knowledge and resources to resolve t echnical issues. Originality/value: Prior to gamification of the system, only the most expert users regu larly utilized all the tools. The user base is now more knowl edgable about the system and some users choose to use the system to publicize their expertise

The effect of macronutrients on glycaemic control: a systematic review of dietary randomised controlled trials in overweight and obese adults with type 2 diabetes in which there was no difference in weight loss between treatment groups

Weight loss is crucial for treating type 2 diabetes mellitus (T2DM). It remains unclear which dietary intervention is best for optimising glycaemic control, or whether weight loss itself is the main reason behind observed improvements. The objective of this study was to assess the effects of various dietary interventions on glycaemic control in overweight and obese adults with T2DM when controlling for weight loss between dietary interventions. A systematic review of randomised controlled trials (RCT) was conducted. Electronic searches of Medline, Embase, Cinahl and Web of Science databases were conducted. Inclusion criteria included RCT with minimum 6 months duration, with participants having BMI≥25·0 kg/m(2), a diagnosis of T2DM using HbA1c, and no statistically significant difference in mean weight loss at the end point of intervention between dietary arms. Results showed that eleven studies met the inclusion criteria. Only four RCT indicated the benefit of a particular dietary intervention over another in improving HbA1c levels, including the Mediterranean, vegan and low glycaemic index (GI) diets. However the findings from one of the four studies showing a significant benefit are questionable because of failure to control for diabetes medications and poor adherence to the prescribed diets. In conclusion there is currently insufficient evidence to suggest that any particular diet is superior in treating overweight and obese patients with T2DM. Although the Mediterranean, vegan and low-GI diets appear to be promising, further research that controls for weight loss and the effects of diabetes medications in larger samples is needed

The experiences of migrants to Australia who stutter

Purpose: Migration is a contemporary, global matter. With the number of international migrants doubling over the past four decades, speech-language pathologists will likely work with migrants who have childhood-onset stuttering. However, combined migration and stuttering experiences have never been investigated specifically. This study is the first to investigate the experiences of migrants to Australia who stutter. Methods: Three women and six men, aged 23 to 66 years old, participated. Data from individual interviews were analysed using Interpretative Phenomenological Analysis to examine the ‘lived experience’ of participants, as well as with NVivo 12 software for the management of coding. Participants also completed The Overall Assessment of the Speaker\u27s Experience of Stuttering (OASES™). Results: The stress experienced from migration interacted and compounded the existing stress of stuttering. Central themes emerged pertaining to the impact of increased stress on self-identity, the interactions of the stresses, as well as the coping strategies/facilitators. Stuttering and other personal factors, such as language(s) spoken and accent, had a negative impact on communication skills. Conclusion: Migration cannot be experienced independently of a stutter, as both are intrinsically linked to self-identity. The combined stress of migration with stuttering amplified the perception of feeling abnormal and resulted in difficulties with establishing a stable self-identity and a sense of belonging in the new context. Participants found strength in the company of others and considered Australia to be accepting of stuttering

Protective actions of des-acylated ghrelin on brain injury and blood-brain barrier disruption after stroke in mice

The major ghrelin forms, acylated ghrelin and des-acylated ghrelin, are novel gastrointestinal hormones. Moreover, emerging evidence indicates that these peptides may have other functions including neuro- and vaso-protection. Here, we investigated whether post-stroke treatment with acylated ghrelin or des-acylated ghrelin could improve functional and histological endpoints of stroke outcome in mice after transient middle cerebral artery occlusion (tMCAo). We found that des-acylated ghrelin (1 mg/kg) improved neurological and functional performance, reduced infarct and swelling, and decreased apoptosis. In addition, it reduced blood-brain barrier (BBB) disruption in vivo and attenuated the hyper-permeability of mouse cerebral microvascular endothelial cells after oxygen glucose deprivation and reoxygenation (OGD + RO). By contrast, acylated ghrelin (1 mg/kg or 5 mg/kg) had no significant effect on these endpoints of stroke outcome. Next we found that des-acylated ghrelin's vasoprotective actions were associated with increased expression of tight junction proteins (occludin and claudin-5), and decreased cell death. Moreover, it attenuated superoxide production, Nox activity and expression of 3-nitrotyrosine. Collectively, these results demonstrate that post-stroke treatment with des-acylated ghrelin, but not acylated ghrelin, protects against ischaemia/reperfusion-induced brain injury and swelling, and BBB disruption, by reducing oxidative and/or nitrosative damage