Influence of radiative damping on the optical-frequency susceptibility

Motivated by recent discussions concerning the manner in which damping appears in the electric polarizability, we show that (a) there is a dependence of the nonresonant contribution on the damping and that (b) the damping enters according to the "opposite sign prescription." We also discuss the related question of how the damping rates in the polarizability are related to energy-level decay rates

Comparison of Cognitive Function after Carotid Artery Stenting versus Carotid Endarterectomy

The effect of carotid artery stenting (CAS) and carotid endarterectomy (CEA) on cognitive function is unclear. Both cognitive improvement and decline have been reported after CAS and CEA. We aimed to compare the changes in postprocedural cognitive function after CAS versus CEA. A systematic qualitative review of the literature was conducted according to the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-analysis statement for studies evaluating the changes in cognitive function after CAS compared with CEA. Thirteen studies (403 CEAs; 368 CAS procedures) comparing the changes in cognitive function after CEA versus CAS were identified. Most studies did not show significant differences in overall cognitive function or only showed a difference in a single cognitive test between the two procedures. A definitive conclusion regarding the effect of CAS versus CEA on cognitive function was not possible owing to heterogeneity in definition, method, timing of assessment, and type of cognitive tests. For the same reasons, performing a meta-analysis was not feasible. The lack of standardization of specific cognitive tests and timing of assessment of cognitive function after CAS and CEA do not allow for definite conclusions to be drawn. Larger, adequately-powered and appropriately designed studies are required to accurately evaluate the effect of CAS versus CEA on postprocedural cognitive function

Velocity of sound in a Bose-Einstein condensate in the presence of an optical lattice and transverse confinement

We study the effect of the transverse degrees of freedom on the velocity of sound in a Bose-Einstein condensate immersed in a one-dimensional optical lattice and radially confined by a harmonic trap. We compare the results of full three-dimensional calculations with those of an effective 1D model based on the equation of state of the condensate. The perfect agreement between the two approaches is demonstrated for several optical lattice depths and throughout the full crossover from the 1D mean-field to the Thomas Fermi regime in the radial direction.Comment: final versio

Myeloma bone disease : the osteoblast in the spotlight

Lytic bone disease remains a life-altering complication of multiple myeloma, with up to 90% of sufferers experiencing skeletal events at some point in their cancer journey. This tumour-induced bone disease is driven by an upregulation of bone resorption (via increased osteoclast (OC) activity) and a downregulation of bone formation (via reduced osteoblast (OB) activity), leading to phenotypic osteolysis. Treatments are limited, and currently exclusively target OCs. Despite existing bone targeting therapies, patients successfully achieving remission from their cancer can still be left with chronic pain, poor mobility, and reduced quality of life as a result of bone disease. As such, the field is desperately in need of new and improved bone-modulating therapeutic agents. One such option is the use of bone anabolics, drugs that are gaining traction in the osteoporosis field following successful clinical trials. The prospect of using these therapies in relation to myeloma is an attractive option, as they aim to stimulate OBs, as opposed to existing therapeutics that do little to orchestrate new bone formation. The preclinical application of bone anabolics in myeloma mouse models has demonstrated positive outcomes for bone repair and fracture resistance. Here, we review the role of the OB in the pathophysiology of myeloma-induced bone disease and explore whether novel OB targeted therapies could improve outcomes for patients

Nonlinear waves in a cylindrical Bose-Einstein condensate

We present a complete calculation of solitary waves propagating in a steady state with constant velocity v along a cigar-shaped Bose-Einstein trap approximated as infinitely-long cylindrical. For sufficiently weak couplings (densities) the main features of the calculated solitons could be captured by effective one-dimensional (1D) models. However, for stronger couplings of practical interest, the relevant solitary waves are found to be hybrids of quasi-1D solitons and 3D vortex rings. An interesting hierarchy of vortex rings occurs as the effective coupling constant is increased through a sequence of critical values. The energy-momentum dispersion of the above structures is shown to exhibit characteristics similar to a mode proposed sometime ago by Lieb within a strictly 1D model, as well as some rotonlike features.Comment: 10 pages, 12 figure

On the complete analytic structure of the massive gravitino propagator in four-dimensional de Sitter space

With the help of the general theory of the Heun equation, this paper completes previous work by the authors and other groups on the explicit representation of the massive gravitino propagator in four-dimensional de Sitter space. As a result of our original contribution, all weight functions which multiply the geometric invariants in the gravitino propagator are expressed through Heun functions, and the resulting plots are displayed and discussed after resorting to a suitable truncation in the series expansion of the Heun function. It turns out that there exist two ranges of values of the independent variable in which the weight functions can be divided into dominating and sub-dominating family.Comment: 21 pages, 9 figures. The presentation has been further improve

On the Potts model partition function in an external field

We study the partition function of Potts model in an external (magnetic) field, and its connections with the zero-field Potts model partition function. Using a deletion-contraction formulation for the partition function Z for this model, we show that it can be expanded in terms of the zero-field partition function. We also show that Z can be written as a sum over the spanning trees, and the spanning forests, of a graph G. Our results extend to Z the well-known spanning tree expansion for the zero-field partition function that arises though its connections with the Tutte polynomial

Performance of a diagnostic algorithm for functional gastrointestinal disorders

Abstract Review No. AR6Ecushla C. Linedale, Antonina Mikocka-Walus, Andrew D. Vincent, Peter R. Gibson, Jane M. Andrew

Bone pain in multiple myeloma (BPMM) — a protocol for a prospective, longitudinal, observational study

Multiple myeloma (MM) is a bone marrow neoplasia that causes bone pain in 70% patients. While preclinical models of MM have suggested that both nerve sprouting and nerve injury may be causative for the pain, there is a lack of clinical data. Thus, the primary aims of this clinical study are: (1) to provide a deep characterization of the subjective experience of pain and quality of life in MM patients; (2) to investigate disturbances in the bone innervation of MM patients. Secondary aims include exploring correlations between pain and serum inflammatory and bone turnover biomarkers. In a prospective, observational study (clinicaltrials.gov: NCT04273425), patients with suspected MM requiring a diagnostic iliac crest biopsy at Sheffield Teaching Hospital (UK) are invited to participate. Consenting patients answer seven standardized questionnaires assessing pain, quality of life and catastrophizing. Bone turnover biomarkers and inflammatory cytokines are measured in fasting serum samples, and bone innervation is evaluated in diagnostic biopsies. MM patients are invited to a follow-up upon completion of first line treatment. This will be the first deep characterization of pain in MM patients and its correlation with disturbances in bone innervation. Understanding how bone turnover and inflammation correlate to pain in MM is crucial to identify novel analgesic targets for this condition

Stationary solutions of the one-dimensional nonlinear Schroedinger equation: I. Case of repulsive nonlinearity

All stationary solutions to the one-dimensional nonlinear Schroedinger equation under box and periodic boundary conditions are presented in analytic form. We consider the case of repulsive nonlinearity; in a companion paper we treat the attractive case. Our solutions take the form of stationary trains of dark or grey density-notch solitons. Real stationary states are in one-to-one correspondence with those of the linear Schr\"odinger equation. Complex stationary states are uniquely nonlinear, nodeless, and symmetry-breaking. Our solutions apply to many physical contexts, including the Bose-Einstein condensate and optical pulses in fibers.Comment: 11 pages, 7 figures -- revised versio