456 research outputs found
Resolutions of cohomology algebras and other struggles with integer coefficients
There is a well known homotopy Π-algebra resolution of a space by wedges of spheres. An attempt to construct the Eckmann-Hilton dual gives a nice resolution for Fp
coefficients which can then be used in a spectral sequence. For ℤ coefficients the dual construction has several compounding problems illustrating that integral cohomology becomes relatively problematic when we try to include primary operations.peerReviewe
Methylated Trivalent Arsenic-Glutathione Complexes are More Stable than their Arsenite Analog
The trivalent arsenic glutathione complexes arsenic triglutathione,
methylarsonous diglutathione, and dimethylarsinous glutathione are key intermediates
in the mammalian metabolism of arsenite and possibly represent the arsenic species
that are transported from the liver to the kidney for urinary excretion. Despite this, the
comparative stability of the arsenic-sulfur bonds in these complexes has not been
investigated under physiological conditions resembling hepatocyte cytosol. Using
size-exclusion chromatography and a glutathione-containing phosphate buffered saline
mobile phase (5 or 10 mM glutathione, pH 7.4) in conjunction with an
arsenic-specific detector, we chromatographed arsenite, monomethylarsonous acid, and
dimethylarsinous acid. The on-column formation of the corresponding arsenic-glutathione
complexes between 4 and 37°C revealed that methylated arsenic-glutathione complexes are more
stable than arsenic triglutathione. The relevance of these results with regard to the metabolic
fate of arsenite in mammals is discussed
Drug use amongst 12- and 13-year-olds attending emotional and behavioural difficulty units in Belfast.
This article reports on the findings from a survey of 12- and 13-year-old young people with statements of special educational needs who are attending emotional and behavioural difficulty units in Belfast. The existing literature in the area of special education suggests that a gap in contemporary empirical evidence for drug use behaviours of adolescents attending EBD units and other special educational facilities exists at present. In attempting to redress this knowledge gap, the findings from the present study support the opinions of commentators in the field that young people attending EBD units are at a high risk of illicit drug use in comparison with their contemporaries in mainstream school
Unleashing the power of data to drive shared prosperity: A roadmap to a transformative data society
Data is one of the most powerful tools societies currently have at their disposal. Data is already a core resource in everyday life for individuals, communities, businesses, and governments - through social media, search, smart devices
in our homes, data analytics, and the digital services we have come to rely on. In the face of urgent challenges - from tackling Covid, addressing widening inequalities to facing the climate emergency - data has the potential to tackle these most pressing challenges1 and positively improve almost every aspect of social and economic life; driving innovation, creating jobs and economic growth, improving decisionmaking, reducing costs, and changing the way public services are delivered
The Belfast Youth Development Study (BYDS): A prospective cohort study of the initiation, persistence and desistance of substance use from adolescence to adulthood in Northern Ireland
Background:
Substance misuse persists as a major public health issue worldwide with significant costs for society. The development of interventions requires methodologically sound studies to explore substance misuse causes and consequences. This Cohort description paper outlines the design of the Belfast Youth Development (BYDS), one of the largest cohort studies of its kind in the UK. The study was established to address the need for a long-term prospective cohort study to investigate the initiation, persistence and desistance of substance use, alongside life course processes in adolescence and adulthood. The paper provides an overview of BYDS as a longitudinal data source for investigating substance misuse and outlines the study measures, sample retention and characteristics. We also outline how the BYDS data have been used to date and highlight areas ripe for future work by interested researchers.
Methods:
The study began in 2000/1 when participants (n = 3,834) were pupils in their first year of post-primary education (age 10/11 years, school year 8) from over 40 schools in Northern Ireland. Children were followed during the school years: Year 9 (in 2002; aged 12; n = 4,343), Year 10 (in 2003; aged 13; n = 4,522), Year 11 (in 2004; aged 14; n = 3,965) and Year 12 (in 2005; aged 15; n = 3,830) and on two more occasions: 2006/07 (aged 16/17; n = 2,335) and 2010/11 (aged 20/21; n = 2,087). Data were collected on substance use, family, schools, neighbourhoods, offending behaviour and mental health. The most novel aspect of the study was the collection of detailed social network data via friendship nominations allowing the investigation of the spread of substance use via friendship networks. In 2004 (school year 11; respondents aged 14), a sub-sample of participants’ parents (n = 1,097) and siblings (n = 211) also completed measures on substance use and family dynamics.
Results:
The most recent wave (in 2010/2011; respondents aged 20/21 years) indicated lifetime use of alcohol, tobacco and cannabis among the cohort was 94, 70 and 45 per cent, respectively. The paper charts the development of drug use behaviour and some of the key results to date are presented. We have also identified a number of key areas ripe for analysis by interested researchers including sexual health and education.
Conclusions:
We have established a cohort with detailed data from adolescence to young adulthood, supplemented with parent and sibling reports and peer network data. The dataset, allowing for investigation of trajectories of adolescent substance use, associated factors and subsequent long-term outcomes, constitutes an important resource for longitudinal substance misuse research. A planned further wave as the cohort enter their late twenties and potential to link to administrative data sources, will further enrich the datasets
Highly-functionalised difluorinated cyclohexane polyols via the Diels–Alder reaction : regiochemical control via the phenylsulfonyl group
A difluorinated dienophile underwent cycloaddition reactions with a range of furans to afford cycloadducts whichcould be processed regio- and stereoselectively via episulfonium ions, generated by the reaction between their alkenyl groups and phenylsulfenyl chloride. The oxabicyclic products were oxidised to the phenylsulfonyl level and ring opened via E1CB or reductive desulfonative pathways to afford, ultimately, difluorinated cyclohexene or cyclohexane polyols
- …