Evaluation: The Good News for Funders

Program evaluation continues to be one of the most challenging aspects of the grantmaking process. While there are many approaches to evaluation, this publication focuses on participatoryapproaches. Given the decrease of funding and increased focus on accountability, funders are under increasing pressure to demonstrate that they are using their dollars strategically.Funders have different priorities as they approach evaluation. Some are concerned with assessment, others are committed to using evaluation as a learning tool, while still others see capacity-building as central to their mission. Whatever the focus, a participatory approach can helpfunders achieve their goals. A well-planned, inclusive process can build knowledge among the grantees, the grantmaking institution and the broader field.An evaluation that adds the perspectives of the primary stakeholders in the grant's success - the beneficiaries - gives the funder vital information concerning the extent to which the grant is meeting its goals. By including the beneficiaries in the process it enables them to identifyproblems within the program and to provide potential solutions to these challenges.The information and resources contained in this publication have been provided to assist you in selecting an evaluation process that will help you achieve your goals. The tools and strategies suggested have allowed many foundations across the country to increase the impact of their grantmaking and improve relationships between grantors and grantees

Integrating Psychosocial Oncology into the Counseling Curriculum

With nearly two million new cancer diagnoses estimated in 2021 alone, counselors and counselors in training should have some knowledge of the mental health impact that cancer has on individuals and families. The authors of this manuscript present a review of established psychosocial oncology training in other fields and ways to infuse the topic of psychosocial oncology, including how it pertains to working within integrated care teams, into the counseling curriculum via one course or infusion into curriculum to better train counselors to provide their unique contributions to the care of individuals with cancer and their families

La educación universitaria para el cambio en el ámbito local

El Proyecto de Aprendizaje en el Ámbito Local explora maneras de crear una infraestructura más firme para el aprendizaje en materia del cambio en el ámbito local y social. Se centra en mejorar las oportunidades de redacción, investigación, evaluación, docencia, formación y aprendizaje que posibilitan el acceso de los colectivos locales y de sus partidarios a enseñanzas útiles y estimuladoras nacidas de los esfuerzos y la experiencia de sus coetáneos.Peer Reviewe

Reserve Requirements Survey

Banks have a private motive to hold some level of cash and liquid reserves, but the negative externalities of bank runs create a public interest in setting a regulatory level higher than the privately optimal level. We can think of such reserve requirements (RRs) as the original form of liquidity regulation. In this paper, we focus on 14 cases in which central banks adjusted RRs after crises hit, typically to deal with liquidity shortages in the banking system. We observe that RR adjustments have several advantages in a crisis: (1) such changes require little process, and the change for banks can be quick; (2) stigma concerns may be much lower than with emergency lending operations; (3) RRs can be used to fine-tune incentives for holding various types and maturities of assets; and (4) RR easing can complement a central bank’s other liquidity support programs

Blanket Guarantees Survey

This paper surveys 10 blanket guarantee (BG) programs across 13 Key Design Decisions. The defining characteristics of these programs in terms of their inclusion in our BG series are (a) that they guaranteed a broader range of liabilities beyond deposit accounts and (b) that the guarantees covered existing liabilities in addition to newly issued ones. Each case represents an effort to eliminate creditors’ incentive to withdraw funding from institutions by guaranteeing that the funding will be paid back even if the institutions are unable to do so themselves. The main themes that emerge are: (a) the inability of blanket guarantees to address underlying problems without complementary liquidity support and restructuring measures; (b) the importance of credibility, particularly as related to the amount of liabilities guaranteed relative to fiscal resources; (c) the need to address the moral hazards that a blanket guarantee creates, by restricting banks’ behavior during the acute phase of a crisis—for example, through interest-rate caps or bans on aggressive marketing—and by promising to increase official supervisory oversight as the crisis extends into its chronic phase; (d) the importance of effective communication; and (e) the importance of clear political support for a program that represents potentially substantial fiscal costs, which authorities may be unable to quantify at the time of the announcement

Spin-gap opening accompanied by a strong magnetoelastic response in the S=1 magnetic dimer system Ba3BiRu2O9

Neutron diffraction, magnetization, resistivity, and heat capacity measurements on the 6H-perovskite Ba3BiRu2O9 reveal simultaneous magnetic and structural dimerization driven by strong magnetoelastic coupling. An isostructural but strongly displacive first-order transition on cooling through T*=176 K is associated with a change in the nature of direct Ru-Ru bonds within Ru2O9 face-sharing octahedra. Above T*, Ba3BiRu2O9 is an S=1 magnetic dimer system with intradimer exchange interactions J0/kB=320 K and interdimer exchange interactions J'/kB=-160 K. Below T*, a spin-gapped state emerges with \Delta\approx220 K. Ab initio calculations confirm antiferromagnetic exchange within dimers, but the transition is not accompanied by long range-magnetic order.Comment: 5 pages, 5 figures, accepted by Physical Review

Survey of Resolution and Restructuring in Europe: Pre- and Post-BRRD

This paper surveys 19 case studies of bank resolutions and restructurings across 15 Key Design Decisions. It focuses on interventions that occurred in Europe both in the years leading up to the adoption of the Bank Recovery and Resolution Directive (BRRD) in 2014 (when many jurisdictions were constrained by a lack of legal authority) and in the years after the BRRD was in place. The main themes that emerge are: (a) the need for resolution and restructuring to eliminate uncertainty about an institution’s solvency by closing it, recapitalizing it, or merging it with a healthier institution; (b) the importance of effective valuation in achieving this result; (c) the necessity of clarity in the treatment of creditors; and (d) the value of a credible bail-in tool to incentivize creditors to agree to solutions outside of resolution

Recruitment and retention interventions in surgical and wound care trials: A systematic review

Background Recruitment and retention to surgical trials has previously been reported to be problematic, resulting in research waste. Surgery often results in wounds, meaning these trials are likely to have similar populations. There is currently no systematic assessment of effective strategies for these populations and hence, systematic assessment of these was deemed to be of importance. Methods A systematic review was conducted. Studies were eligible if they were randomised controlled trials undertaken to test an intervention to improve recruitment or retention within a surgical or wound based host randomised controlled trial. MEDLINE, EMBASE, Cochrane Library, ORRCA Database and the Northern Ireland Hub for Trials Methodology Research SWAT Repository Store were searched. Two independent reviewers screened the search results and extracted data for eligible studies using a piloted extraction form. A narrative synthesis was used due to a lack of heterogeneity between strategies which prevented meta-analysis. Results A total of 2133 records were identified which resulted in 13 ultimately being included in the review; seven on recruitment and six on retention. All included studies were based within surgical host trials. Four of the seven recruitment studies focussed on the provision of consent information to participants, one focussed on study set up and one on staff training, with only one relating to consent information finding any significant effect. A range of retention strategies were assessed by the included studies, however only two found (pen vs no pen, mailing strategies) found any significant effect. Conclusion The included studies within a trial were all conducted within surgical trials. There was significant variation in strategies used, and limited replications and therefore further assessment may be warranted. Given the lack of studies embedded within wound care trials, further studies in this area are recommended. Trial registration PROSPERO (CRD42020205475)

Mitochondrial respiration contributes to the interferon gamma response in antigen presenting cells [preprint]

The immunological synapse allows antigen presenting cells (APC) to convey a wide array of functionally distinct signals to T cells, which ultimately shape the immune response. The relative effect of stimulatory and inhibitory signals is influenced by the activation state of the APC, which is determined by an interplay between signal transduction and metabolic pathways. While toll-like receptor ligation relies on glycolytic metabolism for the proper expression of inflammatory mediators, little is known about the metabolic dependencies of other critical signals such as interferon gamma (IFNγ). Using CRISPR-Cas9, we performed a series of genome-wide knockout screens in macrophages to identify the regulators of IFNγ-inducible T cell stimulatory or inhibitory proteins MHCII, CD40, and PD-L1. Our multi-screen approach enabled us to identify novel pathways that control these functionally distinct markers. Further integration of these screening data implicated complex I of the mitochondrial respiratory chain in the expression of all three markers, and by extension the IFNγ signaling pathway. We report that the IFNγ response requires mitochondrial respiration, and APCs are unable to activate T cells upon genetic or chemical inhibition of complex I. These findings suggest a dichotomous metabolic dependency between IFNγ and toll-like receptor signaling, implicating mitochondrial function as a fulcrum of innate immunity