Testing Bell's Inequality with Cosmic Photons: Closing the Setting-Independence Loophole

We propose a practical scheme to use photons from causally disconnected cosmic sources to set the detectors in an experimental test of Bell's inequality. In current experiments, with settings determined by quantum random number generators, only a small amount of correlation between detector settings and local hidden variables, established less than a millisecond before each experiment, would suffice to mimic the predictions of quantum mechanics. By setting the detectors using pairs of quasars or patches of the cosmic microwave background, observed violations of Bell's inequality would require any such coordination to have existed for billions of years --- an improvement of 20 orders of magnitude.Comment: 5 pages, 4 figures. Minor edits to closely match journal version to be published in Physical Review Letter

The vertical structure of upper ocean variability at the Porcupine Abyssal Plain during 2012-2013

This study presents the characterization of variability in temperature, salinity and oxygen concentration, including the vertical structure of the variability, in the upper 1000m of the ocean over a full year in the northeast Atlantic. Continuously profiling ocean gliders with vertical resolution between 0.5-1m provide more information on temporal variability throughout the water column than time series from moorings with sensors at a limited number of fixed depths. The heat, salt and dissolved oxygen content are quantified at each depth. While the near surface heat content is consistent with the net surface heat flux, heat content of the deeper layers is driven by gyre-scale water mass changes. Below ~150m, heat and salt content display intraseasonal variability which has not been resolved by previous studies. A mode-1 baroclinic internal tide is detected as a peak in the power spectra of water mass properties. The depth of minimum variability is at ~415m for both temperature and salinity, but this is a depth of high variability for oxygen concentration. The deep variability is dominated by the intermittent appearance of Mediterranean Water, which shows evidence of filamentation. Susceptibility to salt fingering occurs throughout much of the water column for much of the year. Between about 700-900m, the water column is susceptible to diffusive layering, particularly when Mediterranean Water is present. This unique ability to resolve both high vertical and temporal resolution highlights the importance of intraseasonal variability in upper ocean heat and salt content, variations that may be aliased by traditional observing techniques

Forecasting and Optimizing Sensitivity to Low-Frequency Gravitational Waves

Pulsars are among the most exotic objects in our Universe. These rapidlyspinning, high magnetic field neutron stars can be used for a wide range ofscientific studies: from the makeup of their own extremely dense and poorlyunderstood interior to using their extremely regular signals to detect gravita-tional waves (GWs). Pulsar timing continues to expand to broader communi-ties, with larger and more sensitive radio telescopes planned and partnershipsbetween pulsar timing arrays (PTAs) that span the entire globe. A realm ofnew physics with the detection of a background hum of gravitational wavesfrom black holes merging from across the Universe is close at hand. This istruly the age of pulsar timing for low-frequency GW astrophysics.With this work, we seek to expand the current techniques of pulsar timingto the bright future which makes use of Bayesian statistical techniques by moretightly integrating pulsar timing model fits into the current PTA GW analysismethodology. We examine four binary millisecond pulsars, PSRs J1640+2224,J2043+1711, J1600–3053, and J0740+6620, using our generalized Bayesianpulsar timing methods and find consistency with and often improvement uponpublished parameter constraints estimated by general least-squares timingmethods. Our new pulsar masses constraints (medians and 68% confidenceintervals) for our fully general Bayesian timing models are mp = 1.6±1 M⊙ forJ2043+1711 and mp = 2.3+0.9−0.7 M⊙ for J1600–3053, both using the NANOGrav12.5-yr data release, and mp = 2.06 ± 6 M⊙ for J0740+6620 using the datafrom Fonseca et al. (2021).We then assess the sensitivity of current and future GW detectors to in-piralling binary black holes (BBHs). We developed the tool, gwent, for cal-culating detector sensitivities in the three primary GW detector regimes ofground-based, space-based, and PTA GW observatories. We calculate realis-tic signal-to-noise ratios using multi-parameter GW source models and findregions of overlap between ground and space-based observatories as well asspace-based detectors and PTAs for non-spinning, equal mass ratio binaries.We finally use realistic simulated PTA data to assess the detectablil-ity of multiple GW backgrounds (GWBs) simultaneously. We simulate twoGWBs, one from supermassive binary black holes (SMBBHs) with spectrumof γ = 13/3, and a GWB from primordial gravitational waves (PGWs) with aspectrum of γ = 5 that has half the energy density at a frequency of f = 1/yras the SMBBH GWB. We find that the weaker, steeper PGW GWB showsevidence for separability from the stronger, shallower SMBBH GWB after 17years of data. With 20 years of data, we can constrain the injected underlyingPGW GWB spectral index and amplitude to 64% and 110%, respectively. Weuse our findings and methods to outline a basic protocol to search for multiplebackgrounds in future PTA datasets

Astronomical random numbers for quantum foundations experiments

Photons from distant astronomical sources can be used as a classical source of randomness to improve fundamental tests of quantum nonlocality, wave-particle duality, and local realism through Bell's inequality and delayed-choice quantum eraser tests inspired by Wheeler's cosmic-scale Mach-Zehnder interferometer gedankenexperiment. Such sources of random numbers may also be useful for information-theoretic applications such as key distribution for quantum cryptography. Building on the design of an "astronomical random-number generator" developed for the recent "cosmic Bell" experiment [Handsteiner et al., Phys. Rev. Lett. 118, 060401 (2017)], in this paper we report on the design and characterization of a device that, with 20-nanosecond latency, outputs a bit based on whether the wavelength of an incoming photon is greater than or less than 700 nm. Using the one-meter telescope at the Jet Propulsion Laboratory (JPL) Table Mountain Observatory, we generated random bits from astronomical photons in both color channels from 50 stars of varying color and magnitude, and from 12 quasars with redshifts up to $z = 3.9$. With stars, we achieved bit rates of $\sim 1 \times 10^6$ Hz / m$^2$, limited by saturation for our single-photon detectors, and with quasars of magnitudes between 12.9 and 16, we achieved rates between $\sim 10^2$ and $2 \times 10^3$ Hz /m$^2$. For bright quasars, the resulting bitstreams exhibit sufficiently low amounts of statistical predictability as quantified by the mutual information. In addition, a sufficiently high fraction of bits generated are of true astronomical origin in order to address both the locality and freedom-of-choice loopholes when used to set the measurement settings in a test of the Bell-CHSH inequality.Comment: 17 pages, 12 figures. References added and minor edits to match published versio

Guideline update for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 16: Bone graft extenders and substitutes as an adjunct for lumbar fusion

pre-printIn an attempt to enhance the potential to achieve a solid arthrodesis and avoid the morbidity of harvesting autologous iliac crest bone (AICB) for a lumbar fusion, numerous alternatives have been investigated. The use of these fusion adjuncts has become routine despite a lack of convincing evidence demonstrating a benefit to justify added costs or potential harm. Potential alternatives to AICB include locally harvested autograft, calcium-phosphate salts, demineralized bone matrix (DBM), and the family of bone morphogenetic proteins (BMPs). In particular, no option has created greater controversy than the BMPs. A significant increase in the number of publications, particularly with respect to the BMPs, has taken place since the release of the original guidelines. Both DBM and the calciumphosphate salts have demonstrated efficacy as a graft extender or as a substitute for AICB when combined with local autograft. The use of recombinant human BMP-2 (rhBMP-2) as a substitute for AICB, when performing an interbody lumbar fusion, is considered an option since similar outcomes have been observed; however, the potential for heterotopic bone formation is a concern. The use of rhBMP-2, when combined with calcium phosphates, as a substitute for AICB, or as an extender, when used with local autograft or AICB, is also considered an option as similar fusion rates and clinical outcomes have been observed. Surgeons electing to use BMPs should be aware of a growing body of literature demonstrating unique complications associated with the use of BMPs

Guideline update for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 1: Introduction and methodology

pre-printFusion procedures are an accepted and successful management strategy to alleviate pain and/or neurological symptoms associated with degenerative disease of the lumbar spine. In 2005, the first version of the "Guidelines for the performance of fusion procedures for degenerative disease of the lumbar spine" was published in the Journal of Neurosurgery: Spine. In an effort to incorporate evidence obtained since the original publication of these guidelines, an expert panel of neurosurgical and orthopedic spine specialists was convened in 2009. Topics reviewed were essentially identical to the original publication. Selected manuscripts from the first iteration of these guidelines as well as relevant publications between 2005 through 2011 were reviewed. Several modifications to the methodology of guideline development were adopted for the current update. In contrast to the 2005 guidelines, a 5-tiered level of evidence strategy was employed, primarily allowing a distinction between lower levels of evidence. The qualitative descriptors (standards/guidelines/options) used in the 2005 recommendations were abandoned and replaced with grades to reflect the strength of medical evidence supporting the recommendation. Recommendations that conflicted with the original publication, if present, were highlighted at the beginning of each chapter. As with the original guideline publication, the intent of this update is to provide a foundation from which an appropriate treatment strategy can be formulated

Guideline update for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 17: Bone growth stimulators as an adjunct for lumbar fusion

pre-printThe relationship between the formation of a solid arthrodesis and electrical and electromagnetic energy is well established; most of the information on the topic, however, pertains to the healing of long bone fractures. The use of both invasive and noninvasive means to supply this energy and supplement spinal fusions has been investigated. Three forms of electrical stimulation are routinely used: direct current stimulation (DCS), pulsed electromagnetic field stimulation (PEMFS), and capacitive coupled electrical stimulation (CCES). Only DCS requires the placement of electrodes within the fusion substrate and is inserted at the time of surgery. Since publication of the original guidelines, few studies have investigated the use of bone growth stimulators. Based on the current review, no conflict with the previous recommendations was generated. The use of DCS is recommended as an option for patients younger than 60 years of age, since a positive effect on fusion has been observed. The same, however, cannot be stated for patients over 60, because DCS did not appear to have an impact on fusion rates in this population. No study was reviewed that investigated the use of CCES or the routine use of PEMFS. A single low-level study demonstrated a positive impact of PEMFS on patients undergoing revision surgery for pseudarthrosis, but this single study is insufficient to recommend for or against the use of PEMFS in this patient population

Resting-State Functional Connectivity in Late-Life Depression: Higher Global Connectivity and More Long Distance Connections

Functional magnetic resonance imaging recordings in the resting-state (RS) from the human brain are characterized by spontaneous low-frequency fluctuations in the blood oxygenation level dependent signal that reveal functional connectivity (FC) via their spatial synchronicity. This RS study applied network analysis to compare FC between late-life depression (LLD) patients and control subjects. Raw cross-correlation matrices (CM) for LLD were characterized by higher FC. We analyzed the small-world (SW) and modular organization of these networks consisting of 110 nodes each as well as the connectivity patterns of individual nodes of the basal ganglia. Topological network measures showed no significant differences between groups. The composition of top hubs was similar between LLD and control subjects, however in the LLD group posterior medial-parietal regions were more highly connected compared to controls. In LLD, a number of brain regions showed connections with more distant neighbors leading to an increase of the average Euclidean distance between connected regions compared to controls. In addition, right caudate nucleus connectivity was more diffuse in LLD. In summary, LLD was associated with overall increased FC strength and changes in the average distance between connected nodes, but did not lead to global changes in SW or modular organization