Field implementation of cement-based composite strengthening technologies

With infrastructure continuing to age, technologies are being developed to strengthen structures as a more sustainable option than replacement. The use of fiber-reinforced cementitious matrix (FRCM) strengthening systems is a promising new technology for adding flexural and shear capacity to existing reinforced concrete members. While cement based systems with carbon, PBO, and steel have all been implemented in a lab setting, there is not research data available for installation in the field. FRCM composites have advantages over more widely used fiber reinforced polymer (FRP) composites such as heat resistance and compatibility with concrete substrate. FRP systems have previously been field tested, giving confidence for the growth of FRCM use. This study aimed to validate the use of cement-based systems for field implementation. Missouri Bridge P-0058, a structurally deficient bridge in southern Missouri, was recently selected and six of its twelve girders were strengthened using four different composite systems, three of which are cement-based. A parametric study was conducted to help choose the final design that will give the best information in the future. A pre-strengthening load test was conducted to get a baseline of the bridge\u27s stiffness, so that future tests can capture the change due to the strengthening as well as potential loss of stiffness over time. The Missouri Department of Transportation has agreed to allow the girders to be brought to the campus of Missouri University of Science and Technology when the bridge is decommissioned. On campus, destructive testing will give valuable information about the field strengthened and field conditioned beams --Abstract, page iii

2018 ANDS Webinar Slides "Research Data Storage and sharing: a UQ journey"

The University of Queensland has developed the UQ Research Data Manager (UQRDM) to provide researchers and higher degree by research students with a means to practise good stewardship of research data. The UQRDM also facilitates collaboration among researchers, both within UQ and other Australian and overseas institutions. External partners can access their project’s research data easily, using their own institutional credentials. In addition to research data storage, the system provides automatically generated and downloadable data management plans that researchers can use in grant, ethics and industry funding applications. The system will also close the loop between working data and managed data collections. This presentation was a webinar organised by ANDS, Nectar and RDS on 13 June 2018

Evaluation of sUAS Education and Training Tools

The wide distribution and demographic composition of students seeking small unmanned aircraft system (sUAS) education presents a need to fully understand the capabilities, limitations, and dependencies of effective training tools. Concepts, practices, and technologies associated with modeling and simulation, immersive gaming, augmented and mixed-reality, and remote operation have demonstrated efficacy to support engaged student learning and objective satisfaction. Identification and comparison of key attributes critical to an aviation educational framework, such as competency-based training, enables educational designers to identify those tools with the highest potential to support successful learning. A series of factors, such as system performance, regulatory compliance, environmental conditions, technological familiarity, and personal experience, require consideration in the selection, optimization, and application of such tools. Embry-Riddle and the Sinclair College National UAS Training and Certification Center have overseen the development, launch, and sustainment of respective sUAS education programs. Effectiveness of these programs is dependent on continuous evaluation of tools, specific to educational settings. A relevant example was the assessment of popular multirotor sUAS conducted by ERAU-W, which led to publication of the “Small Unmanned Aircraft System Consumer Guide” and selection of the Parrot BeBop 2 platform to support sUAS operations curricula. The intent of this work is to present critical considerations, including influencing factors and dependencies, associated with the selection and adoption of technological tools best supporting sUAS education. Background details; emerging approaches, models, and technologies; and examples of past tool evaluation, inclusive of assessment criteria and observations, are discussed. Finally, a series of reflective remarks, including recommendations, relating to evaluation, adaptation, and incorporation of future tools supporting sUAS education are presented

Defining Levels of Learning for Strengths Development Programs in Pharmacy

The Clifton StrengthsFinder® is an online measure of personal talent that identifies where an individual’s greatest potential for building strengths exists. This paper describes a framework for strengths education in pharmacy which includes introductory, intermediate and advanced levels of learning. The use of the StrengthsFinder® assessment and supporting workshops aids student pharmacists, pharmacy residents and practitioners in identifying and refining their talents and connecting talents to roles in the profession. Additional learning strategies support a learner’s progression to intermediate and advanced levels of learning, which focus on the application of strengths in teams, leadership, and organizational development. By articulating and recognizing levels of learning around strengths-related content and skills, strong instructional design is fostered. Optimal design includes development of a sequence of learning opportunities delivered over time, a roll-out plan and consideration of the instructional resources required

Defining Levels of Learning for Strengths Development Programs in Pharmacy

The Clifton StrengthsFinder™ is an online measure of personal talent that identifies where an individual's greatest potential for building strengths exists. This paper describes a framework for strengths education in pharmacy which includes introductory, intermediate and advanced levels of learning. The use of the StrengthsFinder™ assessment and supporting workshops aids student pharmacists, pharmacy residents and practitioners in identifying and refining their talents and connecting talents to roles in the profession. Additional learning strategies support a learner's progression to intermediate and advanced levels of learning, which focus on the application of strengths in teams, leadership, and organizational development. By articulating and recognizing levels of learning around strengths-related content and skills, strong instructional design is fostered. Optimal design includes development of a sequence of learning opportunities delivered over time, a roll-out plan and consideration of the instructional resources required

Inviting Scholarship in Leadership in Pharmacy

oai:pubs.lib.umn.edu:article/184Type: Invitatio

Dataset to support : FHI-aims benchmark for BEEF-vdW, vdW-DF2 and mBEEFvdW

We have performed a benchmark of the BEEF-vdW, mBEEF-vdW and vdW-DF2 implementations in the all-electron electronic structure code in FHIaims against the S22 benchmark set

Aspirin for the prevention of cognitive decline in the elderly: rationale and design of a neuro-vascular imaging study (ENVIS-ion)

<p>Abstract</p> <p>Background</p> <p>This paper describes the rationale and design of the ENVIS-ion Study, which aims to determine whether low-dose aspirin reduces the development of white matter hyper-intense (WMH) lesions and silent brain infarction (SBI). Additional aims include determining whether a) changes in retinal vascular imaging (RVI) parameters parallel changes in brain magnetic resonance imaging (MRI); b) changes in RVI parameters are observed with aspirin therapy; c) baseline cognitive function correlates with MRI and RVI parameters; d) changes in cognitive function correlate with changes in brain MRI and RVI and e) whether factors such as age, gender or blood pressure influence the above associations.</p> <p>Methods/Design</p> <p>Double-blind, placebo-controlled trial of three years duration set in two Australian academic medical centre outpatient clinics. This study will enrol 600 adults aged 70 years and over with normal cognitive function and without overt cardiovascular disease. Subjects will undergo cognitive testing, brain MRI and RVI at baseline and after 3 years of study treatment. All subjects will be recruited from a 19,000-patient clinical outcome trial conducted in Australia and the United States that will evaluate the effects of aspirin in maintaining disability-free longevity over 5 years. The intervention will be aspirin 100 mg daily versus matching placebo, randomized on a 1:1 basis.</p> <p>Discussion</p> <p>This study will improve understanding of the mechanisms at the level of brain and vascular structure that underlie the effects of aspirin on cognitive function. Given the limited access and high cost of MRI, RVI may prove useful as a tool for the identification of individuals at high risk for the development of cerebrovascular disease and cognitive decline.</p> <p>Trial Registration</p> <p>clinicaltrials.gov Identifier: <a href="http://www.clinicaltrials.gov/ct2/show/NCT01038583">NCT01038583</a></p

Epac as a novel effector of airway smooth muscle relaxation

Dysfunctional regulation of airway smooth muscle tone is a feature of obstructive airway diseases such as asthma and chronic obstructive pulmonary disease. Airway smooth muscle contraction is directly associated with changes in the phosphorylation of myosin light chain (MLC), which is increased by Rho and decreased by Rac. Although cyclic adenosine monophosphate (cAMP)-elevating agents are believed to relieve bronchoconstriction mainly via activation of protein kinase A (PKA), here we addressed the role of the novel cAMP-mediated exchange protein Epac in the regulation of airway smooth muscle tone. Isometric tension measurements showed that specific activation of Epac led to relaxation of guinea pig tracheal preparations pre-contracted with methacholine, independently of PKA. In airway smooth muscle cells, Epac activation reduced methacholine-induced MLC phosphorylation. Moreover, when Epac was stimulated, we observed a decreased methacholine-induced RhoA activation, measured by both stress fibre formation and pull-down assay whereas the same Epac activation prevented methacholine-induced Rac1 inhibition measured by pull-down assay. Epac-driven inhibition of both methacholine-induced muscle contraction by Toxin B-1470, and MLC phosphorylation by the Rac1-inhibitor NSC23766, were significantly attenuated, confirming the importance of Rac1 in Epac-mediated relaxation. Importantly, human airway smooth muscle tissue also expresses Epac, and Epac activation both relaxed pre-contracted human tracheal preparations and decreased MLC phosphorylation. Collectively, we show that activation of Epac relaxes airway smooth muscle by decreasing MLC phosphorylation by skewing the balance of RhoA/Rac1 activation towards Rac1. Therefore, activation of Epac may have therapeutical potential in the treatment of obstructive airway diseases