Socioeconomic deprivation as measured by the index of multiple deprivation and its association with low sex hormone binding globulin in women

ACKNOWLEDGEMENTS M.L., I.L. and A.H.H. participated in the study concept and design, acquisition of data, study analysis, interpretation of data, drafting of the manuscript. D.M. provided statistical expertise. R.D., A.J.H., and A.F. participated in the interpretation of data and critical revision of the manuscript.Peer reviewedPublisher PD

Disparities in Health-Related Quality of Life among Adolescent and Young Adult (AYA) Cancer Survivors

https://openworks.mdanderson.org/sumexp22/1067/thumbnail.jp

Identification of cardiovascular disparities among Black and Hispanic survivors of adolescent and young adult (AYA) lymphoma

https://openworks.mdanderson.org/sumexp22/1055/thumbnail.jp

60 Validated Planets from K2 Campaigns 5-8

We present a uniform analysis of 155 candidates from the second year of NASA's $K2$ mission (Campaigns 5-8), yielding 60 statistically validated planets spanning a range of properties, with median values of $R_p$ = 2.5 $R_\oplus$, $P$ = 7.1 d, $T_\mathrm{eq}$ = 811 K, and $J$ = 11.3 mag. The sample includes 24 planets in 11 multi-planetary systems, as well as 18 false positives, and 77 remaining planet candidates. Of particular interest are 18 planets smaller than 2 $R_\oplus$, five orbiting stars brighter than $J$ = 10 mag, and a system of four small planets orbiting the solar-type star EPIC 212157262. We compute planetary transit parameters and false positive probabilities using a robust statistical framework and present a complete analysis incorporating the results of an intensive campaign of high resolution imaging and spectroscopic observations. This work brings the $K2$ yield to over 360 planets, and by extrapolation we expect that $K2$ will have discovered $\sim$600 planets before the expected depletion of its on-board fuel in late 2018.Comment: 33 pages, 13 figures, 5 tables, accepted for publication in A

K2 Discovers a Busy Bee: An Unusual Transiting Neptune Found in the Beehive Cluster

Open clusters have been the focus of several exoplanet surveys but only a few planets have so far been discovered. The \emph{Kepler} spacecraft revealed an abundance of small planets around small, cool stars, therefore, such cluster members are prime targets for exoplanet transit searches. Kepler's new mission, K2, is targeting several open clusters and star-forming regions around the ecliptic to search for transiting planets around their low-mass constituents. Here, we report the discovery of the first transiting planet in the intermediate-age (800 Myr) Beehive cluster (Praesepe). K2-95 is a faint ($\mathrm{Kp = 15.5\,mag}$) $\mathrm{M3.0\pm0.5}$ dwarf from K2's Campaign 5 with an effective temperature of $\mathrm{3471 \pm 124\,K}$, approximately solar metallicity and a radius of $\mathrm{0.402 \pm 0.050 \,R_\odot}$. We detected a transiting planet with a radius of $\mathrm{3.47^{+0.78}_{-0.53} \, R_\oplus}$ and an orbital period of 10.134 days. We combined photometry, medium/high-resolution spectroscopy, adaptive optics/speckle imaging and archival survey images to rule out any false positive detection scenarios, validate the planet, and further characterize the system. The planet's radius is very unusual as M-dwarf field stars rarely have Neptune-sized transiting planets. The comparatively large radius of K2-95b is consistent with the other recently discovered cluster planets K2-25b (Hyades) and K2-33b (Upper Scorpius), indicating systematic differences in their evolutionary states or formation. These discoveries from K2 provide a snapshot of planet formation and evolution in cluster environments and thus make excellent laboratories to test differences between field-star and cluster planet populations.Comment: 14 pages, 8 figues. Accepted for publication in A

Characterizing K2 Candidate Planetary Systems Orbiting Low-Mass Stars II: Planetary Systems Observed During Campaigns 1-7

We recently used near-infrared spectroscopy to improve the characterization of 76 low-mass stars around which K2 had detected 79 candidate transiting planets. 29 of these worlds were new discoveries that had not previously been published. We calculate the false positive probabilities that the transit-like signals are actually caused by non-planetary astrophysical phenomena and reject five new transit-like events and three previously reported events as false positives. We also statistically validate 17 planets (7 of which were previously unpublished), confirm the earlier validation of 22 planets, and announce 17 newly discovered planet candidates. Revising the properties of the associated planet candidates based on the updated host star characteristics and refitting the transit photometry, we find that our sample contains 21 planets or planet candidates with radii smaller than 1.25 R⊕, 18 super-Earths (1.25–2 R⊕), 21 small Neptunes (2–4 R⊕), three large Neptunes (4–6 R⊕), and eight giant planets (>6 R⊕). Most of these planets are highly irradiated, but EPIC 206209135.04 (K2-72e, 1.29^(+0.14)_(-0.13) R⊕), EPIC 211988320.01 (R_p = 2.86^(+0.16)_(-0.15) R⊕), and EPIC 212690867.01 (2.20^(+0.19)_(-0.18) R⊕) orbit within optimistic habitable zone boundaries set by the "recent Venus" inner limit and the "early Mars" outer limit. In total, our planet sample includes eight moderately irradiated 1.5–3 R⊕ planet candidates (F_p ≾ 20 F⊕) orbiting brighter stars (Ks < 11) that are well-suited for atmospheric investigations with the Hubble, Spitzer, and/or James Webb Space Telescopes. Five validated planets orbit relatively bright stars (Kp < 12.5) and are expected to yield radial velocity semi-amplitudes of at least 2 m s^(−1). Accordingly, they are possible targets for radial velocity mass measurement with current facilities or the upcoming generation of red optical and near-infrared high-precision RV spectrographs

GPX-Macrophage Expression Atlas: A database for expression profiles of macrophages challenged with a variety of pro-inflammatory, anti-inflammatory, benign and pathogen insults

BACKGROUND: Macrophages play an integral role in the host immune system, bridging innate and adaptive immunity. As such, they are finely attuned to extracellular and intracellular stimuli and respond by rapidly initiating multiple signalling cascades with diverse effector functions. The macrophage cell is therefore an experimentally and clinically amenable biological system for the mapping of biological pathways. The goal of the macrophage expression atlas is to systematically investigate the pathway biology and interaction network of macrophages challenged with a variety of insults, in particular via infection and activation with key inflammatory mediators. As an important first step towards this we present a single searchable database resource containing high-throughput macrophage gene expression studies. DESCRIPTION: The GPX Macrophage Expression Atlas (GPX-MEA) is an online resource for gene expression based studies of a range of macrophage cell types following treatment with pathogens and immune modulators. GPX-MEA follows the MIAME standard and includes an objective quality score with each experiment. It places special emphasis on rigorously capturing the experimental design and enables the searching of expression data from different microarray experiments. Studies may be queried on the basis of experimental parameters, sample information and quality assessment score. The ability to compare the expression values of individual genes across multiple experiments is provided. In addition, the database offers access to experimental annotation and analysis files and includes experiments and raw data previously unavailable to the research community. CONCLUSION: GPX-MEA is the first example of a quality scored gene expression database focussed on a macrophage cellular system that allows efficient identification of transcriptional patterns. The resource will provide novel insights into the phenotypic response of macrophages to a variety of benign, inflammatory, and pathogen insults. GPX-MEA is available through the GPX website at