2,095 research outputs found

    How students at a Christian university understand the university\u27s faith committment

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    Faith commitment is central to the identity and mission of institutions identifying themselves specifically as Christian Universities. Therefore, their effectiveness in communicating that faith commitment to their students is essential to their success. This project explored how students at one such university gained their understanding of their university’s faith commitment. Its exploratory intent and deliberate focus on the student perspective merited an inductive approach and research methods reflecting a qualitative paradigm. Data were collected at one university using multiple student focus groups. Ultimately, this data shaped a valuable ”insider” perspective on how myriad encounters with university people, programs, and policies shaped students’ individual understanding of the university’s faith commitment. Focus group discussions proved rich and revealed students’ awareness of the university’s faith commitment, appreciation for its distinctiveness, and affirmation of its intentions to make this commitment apparent to campus constituents. Students consistently described the university’s faith commitment as both central to its identity and significant in their own decisions to enroll and persist. They proved attentive to its expression in diverse contexts and encounters

    Carbamazepine on a carbamazepine monolayer forms unique 1D supramolecular assemblies

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    High-resolution STM imaging of the structures formed by carbamazepine molecules adsorbed onto a pseudo-ordered carbamazepine monolayer on Au(111) shows the formation of previously unreported 1-dimensional supramolecular assemblies

    Using the MEAN Stack to implement a RESTful service for an Internet of Things Application

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    This paper examines the components of the MEAN development stack (MongoDb, Express.js, Angular.js, & Node.js), and demonstrate their benefits and appropriateness to be used in implementing RESTful web-service APIs for Inter- net of Things (IoT) appliances. In particular, we show an end- to-end example of this stack and discuss in detail the various components required. The paper also describes an approach to establishing a secure mechanism for communicating with IoT devices, using pull-communications

    On the positional and orientational order of water and methanol around indole: a study on the microscopic origin of solubility

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    Although they are both highly polar liquids, there are a number of compounds, such as many pharmaceuticals, which show vastly different solubilities in methanol compared with water. From theories of the hydrophobic effect, it might be predicted that this enhanced solubility is due to association between drugs and the less polar -CH3 groups on methanol. In this work, detailed analysis on the atomic structural interactions between water, methanol and the small molecule indole – which is a precursor to many drugs and is sparingly soluble in water yet highly soluble in methanol – reveal that indole preferentially interacts with both water and methanol via electrostatic interactions rather than with direction interactions to the –CH3 groups. The presence of methanol hydrogen bonds with p electrons of the benzene ring of indole can explain the increase in solubility of indole in methanol relative to water. In addition, the excess entropy calculations performed here suggest that this solvation is enthalpically rather than entropically driven.Postprint (author's final draft

    On the atomic structure of cocaine in solution

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    Cocaine is an amphiphilic drug which has the ability to cross the blood–brain barrier (BBB). Here, a combination of neutron diffraction and computation has been used to investigate the atomic scale structure of cocaine in aqueous solutions. Both the observed conformation and hydration of cocaine appear to contribute to its ability to cross hydrophobic layers afforded by the BBB, as the average conformation yields a structure which might allow cocaine to shield its hydrophilic regions from a lipophilic environment. Specifically, the carbonyl oxygens and amine group on cocaine, on average, form ~5 bonds with the water molecules in the surrounding solvent, and the top 30% of water molecules within 4 Å of cocaine are localized in the cavity formed by an internal hydrogen bond within the cocaine molecule. This water mediated internal hydrogen bonding suggests a mechanism of interaction between cocaine and the BBB that negates the need for deprotonation prior to interaction with the lipophilic portions of this barrier. This finding also has important implications for understanding how neurologically active molecules are able to interact with both the blood stream and BBB and emphasizes the use of structural measurements in solution in order to understand important biological function.Peer ReviewedPostprint (author's final draft

    Contagion and learning in business networks

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    The purpose of this study is to examine network learning through the application of contagion theories. The transmission of knowledge, sharing of resources, and facilitation of learning through contagion has interested both business-to-business and economic geography researchers. This study responds to calls in both research traditions for research into knowledge and learning at the level of an interfirm network. More specifically, it focuses on developing an understanding of how the contagion of knowledge and ideas and the co-ordination of activities within a network tales place. We achieve this by drawing upon research in both network relationships dynamics and learning processes to investigate the causal mechanisms that drive contagion. We focus on two types of contagion: contagion by cohesion (i.e. the presences and closeness of direct contact with others in the network), and contagion by structural equivalence (i.e. where influence is related to the structural patterns of relationships in the network). We also identify two key mechanisms that act as a barrier to such contagion: isolation and immunity. We explore the implications of these findings for network learning opportunities, specifically learning-by-doing, learning-by-using, and learning-by-interacting

    Contingent factors affecting network learning

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    To increase understanding of the impact of individuals on organizational learning processes, this paper explores the impact of individual cognition and action on the absorptive capacity process of the wider network. In particular this study shows how contingent factors such as social integration mechanisms and power relationships influence how network members engage in, and benefit from, learning. The use of cognitive consistency and sensemaking theory enables examination of how these contingent factors influence the learning processes of two construction industry design teams embedded within more permanent home-organizational structures. A number of practical ways arise by which firms can facilitate organizational learning through their interactions with network partners. Enhancement of learning in and between organizations occurs when members are cognizant of the means by which they connect within a network to create shared meanings, and the way in which they forge ties and share expertise in the learning process they engage in

    CYR61/CCN1: A Novel Mediator of Epidermal Hyperplasia and Inflammation in Psoriasis?

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    The complex pathogenesis of psoriasis is still not fully understood. The study by Sun et al. (2015) suggests that CYR61 (now named CCN1), a secreted matricellular protein, has a role in the pathogenesis of psoriasis, and thus targeting CCN1 represents a potential therapeutic strategy in its treatment

    Involving customers in innovation: knowledgeability and agency as process variables

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    Purpose: Recent research places an increased emphasis on the inclusion of the customer in value creation, learning, and innovation processes yet there remains a gap in our understanding of just how such customer involvement may work. This paper seeks to address this gap by examining two aspects of customer involvement; their knowledgeability and their agency. In addition, we explore three boundaries (semantic, syntactic, and pragmatic) across which relationship development occurs and which mayfacilitate and/or inhibit value co-creation, collaborative learning, and innovation processes. Design/methodology/approach: We utilised three case studies. Two were large scale construction projects in the UK, and one was a global professional accounting firm in the USA. Findings: Customers may become frustrated if not allowed to exercise their agency. However, their involvement can create tensions for suppliers who may have to become more tolerant of divergent goals. In respect of knowledgeability, we found that constraint satisfaction is important in allowing customers to reconcile their personal knowledge schema with that of the collective schema. However, we also noted that customer knowledgeability brings with it challenges for suppliers, who must find ways to add value for such customers. Research implications: We pose a number of further questions relating to the agency and knowledgeability of customers and their inclusion in value co-creation, collaborative learning, and innovation processes. We also highlight the need for guidance in identifying and minimising the barriers to crossing semantic, syntactic and pragmatic boundaries between customers and suppliers. Originality/value: We make an important contribution to research in the field in that we investigate how the inclusion of the customer in business networksalters current assumptions and practices
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