SpinLink: An interconnection system for the SpiNNaker biologically inspired multi-computer

SpiNNaker is a large-scale biologically-inspired multi-computer designed to model very heavily distributed problems, with the flagship application being the simulation of large neural networks. The project goal is to have one million processors included in a single machine, which consequently span many thousands of circuit boards. A computer of this scale imposes large communication requirements between these boards, and requires an extensible method of connecting to external equipment such as sensors, actuators and visualisation systems. This paper describes two systems that can address each of these problems.Firstly, SpinLink is a proposed method of connecting the SpiNNaker boards by using time-division multiplexing (TDM) to allow eight SpiNNaker links to run at maximum bandwidth between two boards. SpinLink will be deployed on Spartan-6 FPGAs and uses a locally generated clock that can be paused while the asynchronous links from SpiNNaker are sending data, thus ensuring a fast and glitch-free response. Secondly, SpiNNterceptor is a separate system, currently in the early stages of design, that will build upon SpinLink to address the important external I/O issues faced by SpiNNaker. Specifically, spare resources in the FPGAs will be used to implement the debugging and I/O interfacing features of SpiNNterceptor

Cyborgs in Latin America

Cyborgs in Latin America explores the ways cultural expression in Latin America has grappled with the changing relationships between technology and human identity. The book takes a literary and cultural studies approach in examining narrative, film and advertising campaigns from Argentina, Bolivia, Chile, Mexico and Uruguay by such artists as Ricardo Piglia, Edmundo Paz Soldán, Carmen Boullosa and Alberto Fuguet among others. Using and criticizing theoretical models developed by Katherine Hayles, Donna Haraway, Gilles Deleuze and Michel Foucault, the book will appeal to specialists and students of Latin American Studies; Posthuman Theory; and Literature, Science and Technology Studies

Abelian covers of surfaces and the homology of the level L mapping class group

We calculate the first homology group of the mapping class group with coefficients in the first rational homology group of the universal abelian $\Z / L \Z$-cover of the surface. If the surface has one marked point, then the answer is \Q^{\tau(L)}, where $\tau(L)$ is the number of positive divisors of $L$. If the surface instead has one boundary component, then the answer is \Q. We also perform the same calculation for the level $L$ subgroup of the mapping class group. Set $H_L = H_1(\Sigma_g;\Z/L\Z)$. If the surface has one marked point, then the answer is \Q[H_L], the rational group ring of $H_L$. If the surface instead has one boundary component, then the answer is \Q.Comment: 32 pages, 10 figures; numerous corrections and simplifications; to appear in J. Topol. Ana

An Intelligent Fuse-box for use with Renewable Energy Sources integrated within a Domestic Environment

This paper outlines a proposal for an intelligent fuse-box that can replace existing fuse-boxes in a domestic context such that a number of renewable energy sources can easily be integrated into the domestic power supply network, without the necessity for complex islanding and network protection. The approach allows intelligent control of both the generation of power and its supply to single or groups of electrical appliances. Energy storage can be implemented in such a scheme to even out the power supplied and simplify the control scheme required, and environmental monitoring and load analysis can help in automatically controlling the supply and demand profiles for optimum electrical and economic efficiency. Simulations of typical scenarios are carried out to illustrate the concept in operation

A Study of the Critical Uncertainty Contributions in the Analysis of PCBs in Ambient Air

The measurement of polychlorinated biphenyls (PCBs) in ambient air requires a complex, multistep sample preparation procedure prior to analysis by gas chromatography—mass spectrometry (GC-MS). Although routine analytical laboratories regularly carry out these measurements, they are often undertaken with little regard to the accurate calculation of measurement uncertainty, or appreciation of the sensitivity of the accuracy of the measurement to each step of the analysis. A measurement equation is developed for this analysis, and the contributory sources to the overall uncertainty when preparing calibration standards and other solutions by gravimetric and volumetric approaches are discussed and compared. For the example analysis presented, it is found that the uncertainty of the measurement is dominated by the repeatability of the GC-MS analysis and suggested that volumetric (as opposed to gravimetric) preparation of solutions does not adversely affect the overall uncertainty. The methodology presented in this work can also be applied to analogous methods for similar analytes, for example, those used to measure polycyclic aromatic hydrocarbons (PAHs), pesticides, dioxins, or furans in ambient air

Robustness from flexibility in the fungal circadian clock

Background Robustness is a central property of living systems, enabling function to be maintained against environmental perturbations. A key challenge is to identify the structures in biological circuits that confer system-level properties such as robustness. Circadian clocks allow organisms to adapt to the predictable changes of the 24-hour day/night cycle by generating endogenous rhythms that can be entrained to the external cycle. In all organisms, the clock circuits typically comprise multiple interlocked feedback loops controlling the rhythmic expression of key genes. Previously, we showed that such architectures increase the flexibility of the clock's rhythmic behaviour. We now test the relationship between flexibility and robustness, using a mathematical model of the circuit controlling conidiation in the fungus Neurospora crassa. Results The circuit modelled in this work consists of a central negative feedback loop, in which the frequency (frq) gene inhibits its transcriptional activator white collar-1 (wc-1), interlocked with a positive feedback loop in which FRQ protein upregulates WC-1 production. Importantly, our model reproduces the observed entrainment of this circuit under light/dark cycles with varying photoperiod and cycle duration. Our simulations show that whilst the level of frq mRNA is driven directly by the light input, the falling phase of FRQ protein, a molecular correlate of conidiation, maintains a constant phase that is uncoupled from the times of dawn and dusk. The model predicts the behaviour of mutants that uncouple WC-1 production from FRQ's positive feedback, and shows that the positive loop enhances the buffering of conidiation phase against seasonal photoperiod changes. This property is quantified using Kitano's measure for the overall robustness of a regulated system output. Further analysis demonstrates that this functional robustness is a consequence of the greater evolutionary flexibility conferred on the circuit by the interlocking loop structure. Conclusions Our model shows that the behaviour of the fungal clock in light-dark cycles can be accounted for by a transcription-translation feedback model of the central FRQ-WC oscillator. More generally, we provide an example of a biological circuit in which greater flexibility yields improved robustness, while also introducing novel sensitivity analysis techniques applicable to a broader range of cellular oscillators

Herbicide impacts on exotic grasses and a population of the critically endangered herb "Calystegia affinis" (Convolvulaceae) on Lord Howe Island

Introduced perennial grasses are capable of altering the habitat of native species, causing reductions in population size and vigour, and potentially affecting life-history processes such as survival, pollination and seedling recruitment. We examined the utility of herbicide treatment on two exotic grasses, Pennisetum clandestinum (Kikuyu) and Stenotaphrum secundatum (Buffalo grass) to restore the habitat of Calystegia affinis, a critically endangered species endemic to Lord Howe and Norfolk Islands. Using two herbicides, Asset (designed to affect only grasses) and Glyphosate (a general herbicide), we compared effectiveness in reducing grass cover on a population of Calystegia affinis. We protected Calystegia plants from the herbicides by ensuring their leaves were covered by plastic bags during herbicide application. Both herbicides were similarly effective in reducing grass cover after four weeks and had no noticeable adverse affect on Calystegia (suggesting the plastic bag protection was effective). After 26 weeks, Glyphosate was more effective in maintaining a reduced grass cover. Plots treated with either herbicide had a greater relative increase in abundance of Calystegia stems compared to untreated controls. The Glyphosate treatment resulted in the greatest relative increase in stem abundance, but this was not significantly greater than in the Asset treatment. We consider that spraying with Glyphosate treatment, with follow-up monitoring and spot-spraying, will assist the recovery of the Calystegia affinis population. Ultimately, the maintenance of a weed-free zone at the forest edge will provide suitable habitat for additional recruitment of this and other native species