Opportunity Knocks: An Economic Analysis of Television Advertisements

Certain aspects of advertising–especially on television–are not easily explained with conventional economic models. In particular, much of the imagery and repetitive thematic content seen in advertisements suggests it is "psychological" in nature, as opposed to "informative". To understand the economic rationale for incorporating such material, we develop a theory of preferences in which information about threshold payoffs induces sudden shifts in demand. These threshold payoffs are best understood in the context of human evolutionary history. Furthermore, the presence of threshold payoffs in consumer preferences gives firms incentive for providing threshold-type information. To examine the use of threshold-related content in television advertisements, we look for this con- tent in a sample of 370 television advertisements. We find considerable evidence that advertisers make strategic use of threshold-type content in television advertisements. Specifically, threshold-related content occurred in 83% of food and beverage advertisements for children and in 71% of advertisements for general audiences. Furthermore, the threshold-related content in children’s food and beverage advertisements occurred with statistically greater frequency than factual content, which isn’t true for food and beverage advertisements for general audiences

Mortality in intensive care: The impact of bacteremia and the utility of systemic inflammatory response syndrome

Background: The purpose of this study was to determine the impact of bacteremia on intensive care unit (ICU) mortality and to develop a bacteremia prediction tool using systemic inflammatory response syndrome (SIRS) criteria. Methods: Patients included those aged >18 years who had blood cultures taken in the ICU from January 1, 2011-December 31, 2013. Eligible patients were identified from microbiology records of the Glasgow Royal Infirmary, Scotland. Clinical and outcome data were gathered from ICU records. Patients with clinically significant bacteremia were matched to controls using propensity scores. SIRS criteria were gathered and used to create decision rules to predict the absence of bacteremia. The main outcome was mortality at ICU discharge. The utility of the decision tools was measured using sensitivity and specificity. Results: One hundred patients had a clinically significant positive blood culture and were matched to 100 controls. Patients with bacteremia had higher ICU mortality (odds ratio [OR], 2.35; P = .001) and longer ICU stay (OR, 17.0 vs 7.8 days; P ≤ .001). Of 1,548 blood culture episodes, 1,274 met ≥2 SIRS criteria (106 significant positive cultures and 1,168 negative cultures). There was no association between SIRS criteria and positive blood cultures (P = .11). A decision rule using 3 SIRS criteria had optimal predictive performance (sensitivity, 56%; specificity, 50%) but low accuracy. Conclusions: ICU patients with bacteremia have increased mortality and length of ICU stay. SIRS criteria cannot be used to identify patients at low risk of bacteremia

Coping and its relation to gender, anxiety, depression, fatigue, cognitive difficulties and somatic symptoms

Background: The first aim of this study was to analyse the structure of coping and to develop a measuring instrument to be used in future work. A second aim was to examine associations between coping scores and negative outcomes (anxiety, depression, fatigue, cognitive difficulties and somatic symptoms). Finally, gender differences in coping with workplace events were examined, as were the relationships between gender and subjective health outcomes. Methodology: A survey of a sample of 240 adults from the South Wales area was conducted at one-time point only. The questionnaire included a factor analysed version of the Ways of Coping Checklist (WCCL) as well as scales measuring anxiety, depression, fatigue, cognitive difficulties and somatic symptoms. Results: Results showed that negative coping styles significantly predicted negative health outcomes, and positive coping styles predicted fewer negative outcomes. No significant differences were found for health outcomes between men and women, but women were significantly more likely to use self-blame and wishful thinking coping. Conclusion: This study demonstrated that coping styles are associated with wellbeing outcomes. Further research should use more independent variables, such as workplace and individual characteristics, to explain more of the variance in health outcomes than just that explained by coping styles alone

Multiscale probability mapping: groups, clusters and an algorithmic search for filaments in SDSS

We have developed a multiscale structure identification algorithm for the detection of overdensities in galaxy data that identifies structures having radii within a user-defined range. Our "multiscale probability mapping" technique combines density estimation with a shape statistic to identify local peaks in the density field. This technique takes advantage of a user-defined range of scale sizes, which are used in constructing a coarse-grained map of the underlying fine-grained galaxy distribution, from which overdense structures are then identified. In this study we have compiled a catalogue of groups and clusters at 0.025 < z < 0.24 based on the Sloan Digital Sky Survey, Data Release 7, quantifying their significance and comparing with other catalogues. Most measured velocity dispersions for these structures lie between 50 and 400 km/s. A clear trend of increasing velocity dispersion with radius from 0.2 to 1 Mpc/h is detected, confirming the lack of a sharp division between groups and clusters. A method for quantifying elongation is also developed to measure the elongation of group and cluster environments. By using our group and cluster catalogue as a coarse-grained representation of the galaxy distribution for structure sizes of <~ 1 Mpc/h, we identify 53 filaments (from an algorithmically-derived set of 100 candidates) as elongated unions of groups and clusters at 0.025 < z < 0.13. These filaments have morphologies that are consistent with previous samples studied.Comment: 22 pages, 14 figures and 6 tables. Accepted for publication in MNRAS. Data products, three-dimensional visualisations and further information about MSPM can be found at http://www.physics.usyd.edu.au/sifa/Main/MSPM/ . v2 contains two additional references. v3 has a slightly altered title and updated reference

Queen control of a key life-history event in a eusocial insect

In eusocial insects, inclusive fitness theory predicts potential queen–worker conflict over the timing of events in colony life history. Whether queens or workers control the timing of these events is poorly understood. In the bumble-bee Bombus terrestris, queens exhibit a ‘switch point’ in which they switch from laying diploid eggs yielding females (workers and new queens) to laying haploid eggs yielding males. By rearing foundress queens whose worker offspring were removed as pupae and sexing their eggs using microsatellite genotyping, we found that queens kept in the complete absence of adult workers still exhibit a switch point. Moreover, the timing of their switch points relative to the start of egg-laying did not differ significantly from that of queens allowed to produce normal colonies. The finding that bumble-bee queens can express the switch point in the absence of workers experimentally demonstrates queen control of a key life-history event in eusocial insects. In addition, we found no evidence that workers affect the timing of the switch point either directly or indirectly via providing cues to queens, suggesting that workers do not fully express their interests in queen–worker conflicts over colony life history

Leveraging Sport Mega-Events: New Model or Convenient Justification?

A range of recent studies have shown that the social and economic impacts of mega-events are often disappointing. This has stimulated interest in the notion of leveraging; an approach which views mega-events as a resource which can be levered to achieve outcomes which would not have happened automatically by staging an event. This paper aims to advance understanding about leveraging – by exploring the rationale for this approach and by identifying different types of leveraging and their relative merits. The work critically explores whether mega-event leveraging represents a new approach or whether it simply provides a convenient justification for expensive and controversial mega-event projects. The paper aims to enhance conceptual understanding, rather than to explore a specific case empirically; but a series of examples are used for illustrative purposes. These are drawn from projects adopted in association with the London 2012 Olympic and Paralympic Games

A novel co-operative mechanism linking TGFβ and Lyn kinase activation to imatinib resistance in chronic myeloid leukaemia cells

The advent of a mechanism specific inhibitor imatinib, targeting Bcr-Abl kinase, has paved the way for new treatment strategies in chronic myeloid leukaemia (CML). However, resistance to imatinib is common in patients and has recently been linked to both transforming growth factor-β (TGFβ) and elevated Lyn kinase activity, although molecular mechanisms remain largely unknown. Here, using leukaemic MYL cell lines derived from CML patients, we show that TGFβ plays a key role in imatinib-resistance via direct effects on Lyn ubiquitination and turnover that results in bursts of Lyn kinase activity, and identify c-cbl is a candidate E3 ubiquitin ligase. Furthermore, blockade of TGFβ signalling activity with the TGFβ receptor kinase inhibitor SB431542 significantly reduces Lyn turnover and activation, and subsequently enhances imatinib-mediated CML cell death in a proteasomal-dependent manner. Collectively, our data reveals novel co-operative mechanisms in CML involving TGFβ and Lyn kinase linked to proteasome function and ubiquitination, and thus supports therapeutic approaches that target TGFβ pathway activity as a strategy for overcoming imatinib-resistance in CML